{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:17:57Z","timestamp":1775099877192,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Grupo de Estudo da Doen\u00e7a Inflamat\u00f3ria Intestinal"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Evidence has been supporting that histological activity of ulcerative colitis [UC] has relevance for the prediction of clinical outcomes in UC patients, such as clinical relapse. In this study, we aimed to compare two histological indexes\u2014the continuous Geboes score [GS] and the Nancy index [NI] \u2014regarding their definitions of histological remission and response, and to determine the ability of faecal calprotectin [FC] levels to discriminate between these histological statuses according to the NI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A large cohort of UC patients [N = 422] who were previously enrolled in other studies was analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>GS and NI were shown to be strongly correlated [correlation coefficient: 0.882, p &amp;lt;0.001], indicating high accordance in the classification of patients as having\/not having histological remission and response. FC levels moderately correlated with NI regarding these histological statuses [correlation coefficient: 0.481, p &amp;lt;0.001], moderately predicted the absence of remission defined by NI &amp;gt;0 {area under the curve (AUC) 0.667 (95% confidence interval [CI] 0.609\u20130.724)}, and were good predictors of the absence of histological response defined by NI &amp;gt;1 (AUC 0.825 [95% CI 0.777\u20130.872]). The optimal FC cut-offs determined to predict the NI-defined histological remission and response were 91 \u03bcg\/g and 106 \u03bcg\/g, when maximising the negative predictive value [NPV].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Due to the higher applicability of the NI, this study encourages the systematic use of this histological index to assess histological remission and response in UC patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjaa010","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T20:10:25Z","timestamp":1579551025000},"page":"1021-1025","source":"Crossref","is-referenced-by-count":26,"title":["Comparison of the Nancy Index With Continuous Geboes Score: Histological Remission and Response in Ulcerative Colitis"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-9668","authenticated-orcid":false,"given":"Fernando","family":"Magro","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Joanne","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-2090","authenticated-orcid":false,"given":"Paula","family":"Borralho","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University of Lisbon, Lisbon, Portugal"}]},{"given":"Cl\u00e1udia Camila","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS - Centre for Health Technology and Services Research, University of Porto, Porto, Portugal"}]},{"given":"Joana","family":"Afonso","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"MedInUP, Centre for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal"}]},{"given":"Paula","family":"Ministro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal"}]},{"given":"Mafalda","family":"Santiago","sequence":"additional","affiliation":[{"name":"CINTESIS - Centre for Health Technology and Services Research, University of Porto, Porto, Portugal"}]},{"given":"Karel","family":"Geboes","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital of KU Leuven and UZ Ghent, Leuven, Belgium"}]},{"given":"F\u00e1tima","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto [Ipatimup], University of Porto, Porto, Portugal"},{"name":"Institute of Research and Innovation in Health [i3S], University of Porto, Porto, Portugal"}]},{"name":"Portuguese IBD Study Group [GEDII]","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Rosa","family":"Coelho","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Cotter","sequence":"additional","affiliation":[]},{"given":"Francisca Dias","family":"de Castro","sequence":"additional","affiliation":[]},{"given":"Helena Tavares","family":"de Sousa","sequence":"additional","affiliation":[]},{"given":"Marta","family":"Salgado","sequence":"additional","affiliation":[]},{"given":"Patr\u00edcia","family":"Andrade","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Vieira","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Figueiredo","sequence":"additional","affiliation":[]},{"given":"Paulo","family":"Caldeira","sequence":"additional","affiliation":[]},{"given":"A","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Duarte","sequence":"additional","affiliation":[]},{"given":"Filipa","family":"\u00c1vila","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Moleiro","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Mendes","sequence":"additional","affiliation":[]},{"given":"S\u00edlvia","family":"Giestas","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Bruno Moreira","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Ana Maria","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Chagas","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"2020073012070847100_CIT0001","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.gie.2018.08.018","article-title":"The emerging role of histologic disease activity assessment in ulcerative colitis","volume":"88","author":"Pai","year":"2018","journal-title":"Gastrointest Endosc"},{"key":"2020073012070847100_CIT0002","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/01.MIB.0000437986.00190.71","article-title":"Histologic evaluation of ulcerative colitis: a systematic review of disease activity indices","volume":"20","author":"Mosli","year":"2014","journal-title":"Inflamm Bowel 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