{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T21:55:28Z","timestamp":1776203728903,"version":"3.50.1"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:00:00Z","timestamp":1591401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Currently, the main targets of drug therapy for ulcerative colitis [UC] are endoscopic and clinical remission. However, there is active discussion about the additional advantages of including histological remission as a target. Accumulating evidence indicates that microscopic activity persists in endoscopically quiescent UC, that histological changes may lag behind clinical remission after treatment, and that absence of histological activity predicts lower rates of relapse, hospitalization, surgery and subsequent neoplasia.<\/jats:p>\n               <jats:p>Obtaining useful information from mucosal biopsies in this setting depends on accurate and consistent evaluation of histological features. However, there is no standardization of biopsy procedures, histological sample processing technique or histological scoring systems, and there is no agreement on the definitions of histological remission, response or activity. Accordingly, a consensus expert panel convened by the European Crohn\u2019s and Colitis Organisation [ECCO] reviewed the literature and agreed a number of position statements regarding harmonization of UC histopathology. The objective was to provide evidence-based guidance for the standardization and harmonization of procedures, definitions and scoring systems for histology in UC, and to reach expert consensus where possible.<\/jats:p>\n               <jats:p>We propose the absence of intraepithelial neutrophils, erosion and ulceration as a minimum requirement for the definition of histological remission. For randomized control trials we recommend the use of the Robarts histopathology index [RHI] or the Nancy index [NI]. For observational studies or in clinical practice we recommend the use of the NI. To predict the risk of future neoplasia in UC, cumulative histological scores over time are more useful than single scores.<\/jats:p>","DOI":"10.1093\/ecco-jcc\/jjaa110","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T19:15:46Z","timestamp":1591038946000},"page":"1503-1511","source":"Crossref","is-referenced-by-count":179,"title":["ECCO Position Paper: Harmonization of the Approach to Ulcerative Colitis Histopathology"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-9668","authenticated-orcid":false,"given":"Fernando","family":"Magro","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"Department of Clinical Pharmacology, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Glen","family":"Doherty","sequence":"additional","affiliation":[{"name":"School of Medicine & Medical Science, University College Dublin, Dublin, Ireland"}]},{"given":"Laurent","family":"Peyrin-Biroulet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nancy University Hospital, Vandoeuvre-Les-Nancy, France"},{"name":"Inserm U1256 NGERE, Lorraine University, Vandoeuvre-Les-Nancy, France"}]},{"given":"Magali","family":"Svrcek","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP-HP, H\u00f4pital Saint-Antoine, Department of Pathology, 184 rue du Faubourg Saint-Antoine, Paris, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-2090","authenticated-orcid":false,"given":"Paula","family":"Borralho","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cuf Descobertas, Lisboa and Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Alissa","family":"Walsh","sequence":"additional","affiliation":[{"name":"Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK"}]},{"given":"Fatima","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine of the University of Porto (FMUP) & Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o (CHUSJ), Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S) & Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal"}]},{"given":"Francesca","family":"Rosini","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, North West London Pathology, Imperial College Healthcare NHS Trust, London, UK"}]},{"given":"Gert","family":"de Hertogh","sequence":"additional","affiliation":[{"name":"Pathology Lab, UZ Gasthuisberg and KULeuven, Leuven, Belgium"}]},{"given":"Luc","family":"Biedermann","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3279-1033","authenticated-orcid":false,"given":"Lieven","family":"Pouillon","sequence":"additional","affiliation":[{"name":"Imelda GI Clinical Research Center, Imeldaziekenhuis Bonheiden, Bonheiden, Belgium"}]},{"given":"Michael","family":"Scharl","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland"}]},{"given":"Monika","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}]},{"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"IBD center, Department of Gastroenterology, Humanitas Clinical and Research Center, IRCCS, Milan, Italy"}]},{"given":"Vincenzo","family":"Villanacci","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Spedali Civili and University of Brescia, Brescia, Italy"}]},{"given":"Roger","family":"Feakins","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Royal Free Hospital, London, UK"}]}],"member":"286","published-online":{"date-parts":[[2020,6,6]]},"reference":[{"key":"2020110703012485600_CIT0001","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/ajg.2015.233","article-title":"Selecting therapeutic targets in inflammatory bowel disease (STRIDE): determining therapeutic goals for Treat-to-Target","volume":"110","author":"Peyrin-Biroulet","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"2020110703012485600_CIT0002","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.crohns.2014.08.011","article-title":"Systematic review: histological remission in inflammatory bowel disease. 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