{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T22:51:08Z","timestamp":1776293468685,"version":"3.50.1"},"reference-count":99,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In inflammatory bowel disease [IBD], mucosal healing is a major therapeutic target and a reliable predictor of clinical course. However, endoscopic mucosal healing is not synonymous with histological healing, and the additional benefits of including histological remission as a target are unclear. In Crohn\u00b4s disease [CD], there are few studies highlighting the value of histological remission as a therapeutic target. Histological activity can persist in CD patients who are in endoscopic remission, and the absence of histological activity may be associated with lower relapse rates. Therefore, standardisation of procedures to evaluate CD histological activity is desirable. Topics that would benefit from standardisation and harmonisation include biopsy procedures, biopsy processing techniques, the content of histological scores, and the definitions of histological remission, histological response, and histological activity. In line with these needs, the European Crohn\u2019s and Colitis Organisation [ECCO] assembled a consensus group with the objective of developing position statements on CD histology based on published evidence and expert consensus. There was agreement that definitions of histological remission should include absence of erosion, ulceration, and mucosal neutrophils; that the absence of neutrophilic inflammation is an appropriate histological target in CD; that CD histological scores, such as the Global Histological Disease Activity Score, lack formal validation; and that histological scoring systems for ulcerative colitis, including the Geboes Score, Robarts Histopathology Index, and Nancy Histological Index, can be used for scoring intestinal biopsies in CD patients.<\/jats:p>","DOI":"10.1093\/ecco-jcc\/jjac006","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T20:10:57Z","timestamp":1641845457000},"page":"876-883","source":"Crossref","is-referenced-by-count":63,"title":["ECCO Position on Harmonisation of Crohn\u2019s Disease Mucosal Histopathology"],"prefix":"10.1093","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-9668","authenticated-orcid":false,"given":"F","family":"Magro","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Unit of Pharmacology and Therapeutics , University of Porto, Porto , Portugal"}]},{"given":"J","family":"Sabino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospitals , KU Leuven, Leuven , Belgium"}]},{"given":"F","family":"Rosini","sequence":"additional","affiliation":[{"name":"Pathology Unit, IRRCCS, S. Orsola-Malpighi University Hospital , Bologna , Italy"}]},{"given":"M","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust , Cambridge , UK"}]},{"given":"P","family":"Borralho","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cuf Descobertas, Lisboa and Faculdade de Medicina da Universidade de Lisboa , Lisbon , Portugal"}]},{"given":"P","family":"Baldin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cliniques Universitaires St-Luc, Universit\u00e9 Catholique de Louvain , Brussels , Belgium"}]},{"given":"S","family":"Danese","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and University Vita-Salute San Raffaele , Milano , Italy"}]},{"given":"A","family":"Driessen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Antwerp, University of Antwerp , Edegem , Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1893-7200","authenticated-orcid":false,"given":"I O","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic Foundation , Cleveland, OH , USA"}]},{"given":"M","family":"Iacucci","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Institute of Immunology and Immunotherapy, NIHR Birmingham Biomedical Research Centre, University of Birmingham , Birmingham , UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3426-6408","authenticated-orcid":false,"given":"N","family":"Noor","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Addenbrooke\u2019s Hospital, Cambridge University Hospitals NHS Trust , Cambridge , UK"}]},{"given":"M","family":"Svrcek","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP-HP, H\u00f4pital Saint-Antoine, Department of Pathology , Paris , France"}]},{"given":"L","family":"Peyrin-Biroulet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nancy University Hospital , Vandoeuvre-Les-Nancy , France"}]},{"given":"R","family":"Feakins","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Royal Free Hospital , London , UK"}]}],"member":"286","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"2022071420382111200_CIT0001","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ecco-jcc\/jjx008","article-title":"Third European evidence-based consensus on diagnosis and management of ulcerative colitis. 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