{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:07:04Z","timestamp":1778825224433,"version":"3.51.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Crohn\u2019s Colitis Organisation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyperbaric oxygen therapy (HBOT) delivers 100% oxygen in a pressurized chamber and enhances tissue oxygenation and neovascularization. While effective in radiation proctitis, acute severe ulcerative colitis, and perianal fistulizing Crohn\u2019s disease, its role in refractory ulcerative colitis (UC) remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PARADOX was a prospective, open-label, phase 2a pilot trial in biologic-experienced patients with moderate-to-severe refractory UC (total Mayo\u2009&amp;gt;\u20095, Mayo endoscopic subscore (MES)\u2009\u2265\u20092, failure of\u2009\u2265\u20092 advanced therapies). Patients received 10 or 20 daily HBOT sessions (2.4 atmospheres absolute, 120\u2009minutes\/day) while continuing stable background therapy. The primary endpoint was composite clinical and endoscopic response at week 12 (\u2265 3-point and 30% Mayo score reduction, rectal bleeding score\u2009=\u20090, and\u2009\u2265\u20091-point decrease in MES). Secondary outcomes included symptomatic, biochemical, and transmural response by intestinal ultrasound (IUS), including perfusion metrics via contrast-enhanced ultrasound (CEUS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 16 patients (8 per group) were included in this pilot study. At week 12, composite response was achieved in 2\/8 (10-session) and 4\/8 (20-session) patients. Improvements in clinical, endoscopic, and IUS parameters were observed in both groups. Clinical responders showed increased CEUS perfusion at week 12 (peak enhancement \u039412.1\u2009dB), while non-responders declined (\u0394 \u20135.4\u2009dB). This pattern was consistent across wash-in\/wash-out metrics, supporting a volume perfusion-based response. HBOT was well tolerated, with no serious adverse events or treatment discontinuations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HBOT is a well-tolerated adjunctive therapy in refractory UC, which improved clinical outcomes and perfusion kinetics. These findings support further evaluation in a randomized, dose-optimized trial.<\/jats:p>\n                    <jats:p>Euclinicaltrials.eu, EU CT number 2024\u2013515278-28-00<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjag065","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:39:23Z","timestamp":1777376363000},"source":"Crossref","is-referenced-by-count":0,"title":["Hyperbaric oxygen therapy alters bowel perfusion and improves outcomes in patients with treatment-refractory ulcerative colitis: a prospective pilot trial"],"prefix":"10.1093","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1001-1291","authenticated-orcid":false,"given":"Lieven","family":"Mulders","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7457-8353","authenticated-orcid":false,"given":"Maarten","family":"Pruijt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joep","family":"Van Oostrom","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esmerij","family":"Van Der Zanden","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amstelland Ziekenhuis , Amstelveen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andra","family":"Neefjes-Borst","sequence":"additional","affiliation":[{"name":"Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pim","family":"Koelink","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Wildenberg","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter","family":"De Jonge","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Ridderikhof","sequence":"additional","affiliation":[{"name":"Department of Hyperbaric Medicine, Amsterdam UMC, University of Amsterdam , Amsterdam,","place":["The Netherlands"]},{"name":"Department of Emergency Medicine, Amsterdam UMC, University of Amsterdam , Amsterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Van Hulst","sequence":"additional","affiliation":[{"name":"Department of Hyperbaric Medicine, Amsterdam UMC, University of Amsterdam , Amsterdam,","place":["The Netherlands"]},{"name":"Department of 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