{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T11:32:40Z","timestamp":1772537560262,"version":"3.50.1"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ECCOJC"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1093\/ecco-jcc\/jjv074","type":"journal-article","created":{"date-parts":[[2015,4,26]],"date-time":"2015-04-26T00:21:27Z","timestamp":1430007687000},"page":"580-588","source":"Crossref","is-referenced-by-count":48,"title":["Clinical Trials in Ulcerative Colitis: A Historical Perspective"],"prefix":"10.1093","volume":"9","author":[{"given":"Pieter","family":"Hindryckx","sequence":"first","affiliation":[]},{"given":"Filip","family":"Baert","sequence":"additional","affiliation":[]},{"given":"Ailsa","family":"Hart","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[]},{"given":"Alessandro","family":"Armuzzi","sequence":"additional","affiliation":[]},{"given":"Laurent","family":"Peyrin-Biroulet","sequence":"additional","affiliation":[]},{"name":"the Clinical Trial Committee Clincom of the European Crohn\u2019s and Colitis Organisation (ECCO)","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2015,4,25]]},"reference":[{"key":"2015062604045414000_9.7.580.1","volume-title":"The Extant Works of Aretaeus, The Cappadocian","author":"Aretaeus","year":"1972"},{"key":"2015062604045414000_9.7.580.2","first-page":"264","article-title":"Morbid appearances in the intestine of Miss Bankes","volume":"2","author":"Wilks","year":"1859","journal-title":"London Medical Gazette"},{"key":"2015062604045414000_9.7.580.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1932.02740680019005"},{"key":"2015062604045414000_9.7.580.4","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.cgh.2014.05.019","article-title":"Thiopurines and risk of colorectal neoplasia in patients with inflammatory bowel disease: a meta-analysis","author":"Jess","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2015062604045414000_9.7.580.5","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22839"},{"key":"2015062604045414000_9.7.580.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2011.06.009"},{"key":"2015062604045414000_9.7.580.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.07.022"},{"key":"2015062604045414000_9.7.580.8","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.44.515.684"},{"key":"2015062604045414000_9.7.580.9","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.0954-6820.1942.tb06841.x","article-title":"Salazopyrin, a new sulfanilamide preparation. A. Therapeutic results in rheumatic polyarthritis. B. Therapeutic effects in ulcerative colitis. C. Toxic manifestations in treatment with sulfanilamide preparations","volume":"110","author":"Svartz","year":"1942","journal-title":"Acta Med Scand"},{"key":"2015062604045414000_9.7.580.10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.0954-6820.1948.tb12083.x","article-title":"The treatment of 124 cases of ulcerative colitis with salazopyrin. Attempts at desensitization in cases of hypersensitiveness to sulphasalazine","volume":"131","author":"Svartz","year":"1948","journal-title":"Acta Med Scand"},{"key":"2015062604045414000_9.7.580.11","first-page":"CD000543","article-title":"Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis","volume":"10","author":"Feagan","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"2015062604045414000_9.7.580.12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1950.00230100002001"},{"key":"2015062604045414000_9.7.580.13","first-page":"809","article-title":"The treatment of chronic idiopathic ulcerative colitis with adrenocorticotrophic hormone","volume":"29","author":"Dutoit","year":"1950","journal-title":"J Clin Invest"},{"key":"2015062604045414000_9.7.580.14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0016-5085(51)80211-7","article-title":"The effect of ACTH on nonspecific ulcerative colitis","volume":"17","author":"Rossmiller","year":"1951","journal-title":"Gastroenterology"},{"key":"2015062604045414000_9.7.580.15","first-page":"10","article-title":"Observations on the influence of corticotropins upon the course of chronic ulcerative colitis","volume":"66","author":"Palmer","year":"1954","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"2015062604045414000_9.7.580.16","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4947.1041"},{"key":"2015062604045414000_9.7.580.17","doi-asserted-by":"publisher","DOI":"10.1136\/gut.1.3.217"},{"key":"2015062604045414000_9.7.580.18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.3.3.207"},{"key":"2015062604045414000_9.7.580.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.09.005"},{"key":"2015062604045414000_9.7.580.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)92080-9"},{"key":"2015062604045414000_9.7.580.21","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0140-6736(77)90831-5","article-title":"An experiment to determine the active therapeutic moiety of sulphasalazine","volume":"2","author":"Azad Khan","year":"1977","journal-title":"Lancet"},{"key":"2015062604045414000_9.7.580.22","first-page":"CD000543","article-title":"Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis","volume":"10","author":"Feagan","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"2015062604045414000_9.7.580.23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406303302601"},{"key":"2015062604045414000_9.7.580.24","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/0016-5085(94)90394-8","article-title":"A placebo-controlled trial of cyclosporine enemas for mildly to moderately active left-sided ulcerative colitis","volume":"106","author":"Sandborn","year":"1994","journal-title":"Gastroenterology"},{"key":"2015062604045414000_9.7.580.25","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.23983"},{"key":"2015062604045414000_9.7.580.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01214-9"},{"key":"2015062604045414000_9.7.580.27","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.081794"},{"key":"2015062604045414000_9.7.580.28","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613046"},{"key":"2015062604045414000_9.7.580.29","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.agast961652"},{"key":"2015062604045414000_9.7.580.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2011.03.012"},{"key":"2015062604045414000_9.7.580.31","doi-asserted-by":"crossref","unstructured":"Carbonnel F Colombel JF Filippi J Methotrexate for corticosteroid-dependent ulcerative colitis: results of a placebo randomized controlled trial. In: ECCO congress 2015; Barcelona. Oral presentation 023.","DOI":"10.1016\/S0016-5085(15)30480-7"},{"key":"2015062604045414000_9.7.580.32","first-page":"930","article-title":"Outline of undesirable effects of ACTH and cortisone","volume":"50","author":"Bakke","year":"1951","journal-title":"Northwest Med"},{"key":"2015062604045414000_9.7.580.33","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5119.387"},{"key":"2015062604045414000_9.7.580.34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0140-6736(65)90973-6","article-title":"Prednisone as maintenance treatment for ulcerative colitis in remission","volume":"1","author":"Lennard-Jones","year":"1965","journal-title":"Lancet"},{"key":"2015062604045414000_9.7.580.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)95624-2"},{"key":"2015062604045414000_9.7.580.36","doi-asserted-by":"publisher","DOI":"10.1136\/gut.14.12.923"},{"key":"2015062604045414000_9.7.580.37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/00365521.1973.12096672","article-title":"The prophylactic effect of salazosulphapyridine in ulcerative colitis during long-term treatment","volume":"8","author":"Riis","year":"1973","journal-title":"Scand J Gastroenterol"},{"key":"2015062604045414000_9.7.580.38","doi-asserted-by":"publisher","DOI":"10.1038\/1831682a0"},{"key":"2015062604045414000_9.7.580.39","doi-asserted-by":"crossref","first-page":"592","DOI":"10.5694\/j.1326-5377.1962.tb20590.x","article-title":"The treatment of chronic ulcerative colitis with 6-mercaptopurine","volume":"49","author":"Bean","year":"1962","journal-title":"Med J Aust"},{"key":"2015062604045414000_9.7.580.40","doi-asserted-by":"publisher","DOI":"10.1007\/BF02233565"},{"key":"2015062604045414000_9.7.580.41","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1966.03100060100027"},{"key":"2015062604045414000_9.7.580.42","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5945.627"},{"key":"2015062604045414000_9.7.580.43","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6844.20"},{"key":"2015062604045414000_9.7.580.44","first-page":"CD007560","article-title":"Methotrexate for maintenance of remission in ulcerative colitis","volume":"3","author":"El-Matary","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"2015062604045414000_9.7.580.45","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200105000-00001"},{"key":"2015062604045414000_9.7.580.46","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.7.998"},{"key":"2015062604045414000_9.7.580.47","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050516"},{"key":"2015062604045414000_9.7.580.48","article-title":"Guideline on the development of new medicinal products for the treatment of ulcerative colitis","author":"European Medicines Agency","year":"2008"},{"key":"2015062604045414000_9.7.580.49","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61084-8"},{"key":"2015062604045414000_9.7.580.50","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.221127"},{"key":"2015062604045414000_9.7.580.51","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.032"},{"key":"2015062604045414000_9.7.580.52","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.048"},{"key":"2015062604045414000_9.7.580.53","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.06.010"},{"key":"2015062604045414000_9.7.580.54","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.10.052"},{"key":"2015062604045414000_9.7.580.55","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904492"},{"key":"2015062604045414000_9.7.580.56","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215734"},{"key":"2015062604045414000_9.7.580.57","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.12.037"},{"key":"2015062604045414000_9.7.580.58","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cgh.2013.07.031","article-title":"Deep remission in Crohn\u2019s disease: is it the end of the placebo effect?","volume":"12","author":"Peyrin-Biroulet","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2015062604045414000_9.7.580.59","first-page":"1099","article-title":"adalimumab induces deep remission in patients with Crohn\u2019s disease","volume":"133","author":"Colombel","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2015062604045414000_9.7.580.60","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.01.035"},{"key":"2015062604045414000_9.7.580.61","article-title":"Concept paper on the revision of the guideline on the 4 development of new medicinal products for the treatment 5 of ulcerative colitis (CHMP\/EWP\/18463\/2006)","author":"European Medicines Agency","year":"2014"},{"key":"2015062604045414000_9.7.580.62","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.12.038"},{"key":"2015062604045414000_9.7.580.63","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000046"},{"key":"2015062604045414000_9.7.580.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2014.03.005"},{"key":"2015062604045414000_9.7.580.65","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.069"},{"key":"2015062604045414000_9.7.580.66","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.03.025"},{"key":"2015062604045414000_9.7.580.67","first-page":"29","article-title":"Mucosal healing in inflammatory bowel disease\u2014a true paradigm of success?","volume":"8","author":"Dave","year":"2012","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"2015062604045414000_9.7.580.68","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-013-0315-7"},{"key":"2015062604045414000_9.7.580.69","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.054"},{"key":"2015062604045414000_9.7.580.70","doi-asserted-by":"publisher","DOI":"10.1007\/BF02233941"},{"key":"2015062604045414000_9.7.580.71","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.2.174"},{"key":"2015062604045414000_9.7.580.72","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.001"},{"key":"2015062604045414000_9.7.580.73","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1053\/j.gastro.2014.08.003","article-title":"Converging goals of treatment for inflammatory bowel disease, from clinical trials and practice","volume":"148","author":"Levesque","year":"2014","journal-title":"Gastroenterology"},{"key":"2015062604045414000_9.7.580.74","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.010"},{"key":"2015062604045414000_9.7.580.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.08.011"},{"key":"2015062604045414000_9.7.580.76","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2014-307477","article-title":"Comparing histological activity indexes in UC","author":"Bressenot","year":"2014","journal-title":"Gut"},{"key":"2015062604045414000_9.7.580.77","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60304-9"},{"key":"2015062604045414000_9.7.580.78","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.056"},{"key":"2015062604045414000_9.7.580.79","doi-asserted-by":"crossref","unstructured":"Khanna R Levesque BG Bressler B Early combined immunosuppression for the management of Crohn\u2019s disease: a community-based cluster randomized trial. In: ECCO Congress, Copenhagen; 2014. Oral presentation OP4.","DOI":"10.1016\/S1873-9946(14)60005-2"},{"key":"2015062604045414000_9.7.580.80","unstructured":"Gottlieb S. The FDA Should Not Mandate Comparative-Effectiveness Trials 2011. http:\/\/www.aei.org\/outlook\/health\/medical-technology\/fda\/the-fda-should-not-mandate-comparative-effectiveness-trials\/"},{"key":"2015062604045414000_9.7.580.81","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020888"},{"key":"2015062604045414000_9.7.580.82","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.02.016"},{"key":"2015062604045414000_9.7.580.83","article-title":"A retrospective analysis: the development of patient reported outcome measures for the assessment of Crohn\u2019s disease activity","author":"Khanna","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"2015062604045414000_9.7.580.84","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-79"},{"key":"2015062604045414000_9.7.580.85","article-title":"Guideline on similar biological medicinal products containing monoclonal antibodies \u2013 non-clinical and clinical issues","author":"European Medicines Agency","year":"2012"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/9\/7\/580\/5138718\/jjv074.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T16:24:43Z","timestamp":1717863883000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-lookup\/doi\/10.1093\/ecco-jcc\/jjv074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,25]]},"references-count":85,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,6,26]]},"published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1093\/ecco-jcc\/jjv074"],"URL":"https:\/\/doi.org\/10.1093\/ecco-jcc\/jjv074","relation":{},"ISSN":["1873-9946","1876-4479"],"issn-type":[{"value":"1873-9946","type":"print"},{"value":"1876-4479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,25]]}}}