{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:58:37Z","timestamp":1773860317247,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Portuguese IBD group"},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PD\/BD\/142890\/2018"],"award-info":[{"award-number":["PD\/BD\/142890\/2018"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>The histological status of ulcerative colitis [UC] patients in clinical and endoscopic remission has gained space as an important prognostic marker and a key component of disease monitoring. Our main aims were to compare two histological indexes\u2014the continuous Geboes score [GS] and the Robarts Histopathology index [RHI]\u2014regarding their definitions of histological remission and response, and the ability of faecal calprotectin [FC] levels to discriminate between these statuses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was an analysis of three prospective cohorts including 422 patients previously enrolled in other studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The two continuous scores [GS and RHI] were shown to be significantly correlated [correlation coefficient of 0.806, p &amp;lt; 0.001] and particularly close regarding their definition of histological response: 95% and 88% of all patients classified as having\/not having [respectively] histological response according to RHI also did so according to GS. Moreover, median FC levels in patients with histological response were lower than those in patients without histological response [GS: 73.00 vs 525.00, p &amp;lt; 0.001; RHI: 73.50 vs 510.00, p &amp;lt; 0.001]; a similar trend was observed when FC levels of patients in histological remission were compared to those of patients with histological activity [GS: 76.00 vs 228.00, p &amp;lt; 0.001; RHI: 73.50 vs 467.00, p &amp;lt; 0.001]. FC levels allowed us to exclude the absence of histological remission [according to RHI] and absence of histological response [according to RHI and GS], with negative predictive values varying from 82% to 96%. However, optimization of the FC cut-off to exclude the absence of histological remission, as for the continuous GS, falls within values that resemble those of the healthy population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The continuous GS and RHI histological scores are strongly correlated in their definitions of histological response. An absence of histological remission could only be excluded at physiological levels of FC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ecco-jcc\/jjz123","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T19:16:22Z","timestamp":1566328582000},"page":"169-175","source":"Crossref","is-referenced-by-count":32,"title":["Comparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and their Relation to Faecal Calprotectin Levels"],"prefix":"10.1093","volume":"14","author":[{"given":"Fernando","family":"Magro","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Department of Biomedicine, Unity of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Joanne","family":"Lopes","sequence":"first","affiliation":[{"name":"Department of Pathology, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-2090","authenticated-orcid":false,"given":"Paula","family":"Borralho","sequence":"first","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University of Lisbon, Lisbon, Portugal"}]},{"given":"Susana","family":"Lopes","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Rosa","family":"Coelho","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Jos\u00e9","family":"Cotter","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hospital da Senhora da Oliveira, Guimar\u00e3es, Portugal"}]},{"given":"Francisca","family":"Dias de Castro","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hospital da Senhora da Oliveira, Guimar\u00e3es, Portugal"}]},{"given":"Helena","family":"Tavares de Sousa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar do Algarve \u2013 Portim\u00e3o Unit, Portim\u00e3o, Portugal"},{"name":"ABC \u2013 Algarve Biomedical Centre, University of Algarve, Faro, Portugal"}]},{"given":"Marta","family":"Salgado","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar do Porto, Hospital de Santo Ant\u00f3nio, Portugal"}]},{"given":"Patr\u00edcia","family":"Andrade","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Ana Isabel","family":"Vieira","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hospital Garcia de Orta, Almada, Portugal"}]},{"given":"Pedro","family":"Figueiredo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hospital Garcia de Orta, Almada, Portugal"}]},{"given":"Paulo","family":"Caldeira","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar do Algarve, Faro, Portugal"}]},{"given":"A","family":"Sousa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar do Algarve, Faro, Portugal"}]},{"given":"Maria A","family":"Duarte","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Divino Esp\u00edrito Santo Hospital, Ponta Delgada, Portugal"}]},{"given":"Filipa","family":"\u00c1vila","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Divino Esp\u00edrito Santo Hospital, Ponta Delgada, Portugal"}]},{"given":"Jo\u00e3o","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Instituto Portugu\u00eas do Oncologia de Lisboa, Lisbon, Portugal"}]},{"given":"Joana","family":"Moleiro","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Instituto Portugu\u00eas do Oncologia de Lisboa, Lisbon, Portugal"}]},{"given":"Sofia","family":"Mendes","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"S\u00edlvia","family":"Giestas","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Paula","family":"Ministro","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal"}]},{"given":"Paula","family":"Sousa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal"}]},{"given":"Raquel","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hospital de Braga, Braga, Portugal"}]},{"given":"Bruno","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hospital de Braga, Braga, Portugal"}]},{"given":"Ana","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hospital Fernando Fonseca, Amadora, Portugal"}]},{"given":"Cristina","family":"Chagas","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal"}]},{"given":"Marilia","family":"Cravo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hospital Beatriz \u00c2ngelo, Loures, Portugal"}]},{"given":"Cl\u00e1udia Camila","family":"Dias","sequence":"first","affiliation":[{"name":"Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS \u2013 Centre for Health Technology and Services Research, Porto, Portugal"}]},{"given":"Joana","family":"Afonso","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Unity of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"MedInUP, Centre for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal"}]},{"given":"Francisco","family":"Portela","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Mafalda","family":"Santiago","sequence":"first","affiliation":[{"name":"CINTESIS \u2013 Centre for Health Technology and Services Research, Porto, Portugal"}]},{"given":"Karel","family":"Geboes","sequence":"first","affiliation":[{"name":"Department of Pathology, University Hospital of KU Leuven and UZ Gent, Leuven, Belgium"}]},{"given":"F\u00e1tima","family":"Carneiro","sequence":"first","affiliation":[{"name":"Department of Pathology, Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), University of Porto, Porto, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"2020042909360529300_CIT0001","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/01.MIB.0000437986.00190.71","article-title":"Histologic evaluation of ulcerative colitis","volume":"20","author":"Mosli","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"2020042909360529300_CIT0002","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.gie.2018.08.018","article-title":"The emerging role of histologic disease activity assessment in ulcerative colitis","volume":"88","author":"Pai","year":"2018","journal-title":"Gastrointest 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