{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:41:16Z","timestamp":1770741676894,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000860","name":"European Society of Cardiology","doi-asserted-by":"publisher","award":["App000080404"],"award-info":[{"award-number":["App000080404"]}],"id":[{"id":"10.13039\/501100000860","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Characterization of left ventricular (LV) geometric pattern and LV mass could provide an important insight into the pathophysiological adaptations of the LV to pressure and\/or volume overload in patients with bicuspid aortic valve (BAV) and significant (\u2265moderate) aortic valve (AV) disease. This study aimed to characterize LV remodelling and its prognostic impact in patients with BAV according to the predominant type of valvular dysfunction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In this international, multicentre BAV registry, 1345 patients [51.0 (37.0\u201363.0) years, 71% male] with significant AV disease were identified. Patients were classified as having isolated aortic stenosis (AS) (n = 669), isolated aortic regurgitation (AR) (n = 499) or mixed aortic valve disease (MAVD) (n = 177). LV hypertrophy was defined as a LV mass index &amp;gt;115 g\/m2 in males and &amp;gt;95 g\/m2 in females. LV geometric pattern was classified as (i) normal geometry: no LV hypertrophy, relative wall thickness (RWT) \u22640.42, (ii) concentric remodelling: no LV hypertrophy, RWT &amp;gt;0.42, (iii) concentric hypertrophy: LV hypertrophy, RWT &amp;gt;0.42, and (iv) eccentric hypertrophy: LV hypertrophy, RWT \u22640.42. Patients were followed-up for the endpoints of event-free survival (defined as a composite of AV repair\/replacement and all-cause mortality) and all-cause mortality. Type of AV dysfunction was related to significant variations in LV remodelling. Higher LV mass index, i.e. LV hypertrophy, was independently associated with the composite endpoint for patients with isolated AS [hazard ratio (HR) 1.08 per 25 g\/m2, 95% confidence interval (CI) 1.00\u20131.17, P = 0.046] and AR (HR 1.19 per 25 g\/m2, 95% CI 1.11\u20131.29, P &amp;lt; 0.001), but not for those with MAVD. The presence of concentric remodelling, concentric hypertrophy and eccentric hypertrophy were independently related to the composite endpoint in patients with isolated AS (HR 1.54, 95% CI 1.06\u20132.23, P = 0.024; HR 1.68, 95% CI 1.17\u20132.42, P = 0.005; HR 1.59, 95% CI 1.03\u20132.45, P = 0.038, respectively), while concentric hypertrophy and eccentric hypertrophy were independently associated with the combined endpoint for those with isolated AR (HR 2.49, 95% CI 1.35\u20134.60, P = 0.004 and HR 3.05, 95% CI 1.71\u20135.45, P &amp;lt; 0.001, respectively). There was no independent association observed between LV remodelling and the combined endpoint for patients with MAVD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>LV hypertrophy or remodelling were independently associated with the composite endpoint of AV repair\/replacement and all-cause mortality for patients with isolated AS and isolated AR, although not for patients with MAVD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjci\/jeab284","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T12:08:54Z","timestamp":1639483734000},"page":"1669-1679","source":"Crossref","is-referenced-by-count":19,"title":["Left ventricular remodelling in bicuspid aortic valve disease"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8258-8802","authenticated-orcid":false,"given":"Steele C","family":"Butcher","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Heart Lung Center , Albinusdreef 2, 2300 RC Leiden , The Netherlands"},{"name":"Department of Cardiology, Royal Perth Hospital , Perth, Western Australia, 197 Wellington St, Perth WA 6000 , Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1868-3095","authenticated-orcid":false,"given":"Stephan M","family":"Pio","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Heart Lung Center , Albinusdreef 2, 2300 RC Leiden , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1589-9026","authenticated-orcid":false,"given":"William K F","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Heart Lung Center , Albinusdreef 2, 2300 RC Leiden , The Netherlands"},{"name":"Department of Cardiology, National University Heart Centre, National University Health System , 5 Lower Kent Ridge Rd, Singapore 119074 , Singapore"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4308-9872","authenticated-orcid":false,"given":"Gurpreet K","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Heart Lung Center , Albinusdreef 2, 2300 RC Leiden , The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1925-9958","authenticated-orcid":false,"given":"Arnold C T","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Princess Alexandra Hospital, The University of Queensland , Brisbane, 199 Ipswich Rd, Woolloongabba QLD 4102 , Australia"}]},{"given":"Rebecca","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Flinders Medical Centre , Flinders Dr, Bedford Park SA 5042, Adelaide , Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2764-2869","authenticated-orcid":false,"given":"Ching-Hui","family":"Sia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Centre, National University Health System , 5 Lower Kent Ridge Rd, Singapore 119074 , Singapore"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-7924","authenticated-orcid":false,"given":"Kian Keong","family":"Poh","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore , 10 Medical Dr, Singapore 117597 , Singapore"}]},{"given":"Ana G","family":"Almeida","sequence":"additional","affiliation":[{"name":"Cardiology Department, Santa Maria University Hospital (CHLN), CAML, CCUL, Lisbon School of Medicine of the Universidade de Lisboa , Av. Prof. Egas Moniz MB, 1649-028 Lisboa , Portugal"}]},{"given":"Ariana","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Ram\u00f3n y Cajal , M-607, 9, 100, 28034 Madrid , Spain"}]},{"given":"Myl\u00e8ne","family":"Shen","sequence":"additional","affiliation":[{"name":"Quebec Heart and Lung Institute, Laval University , 2725 Ch Ste-Foy, Qu\u00e9bec, QC G1V 4G5 , Canada"}]},{"given":"Tiong Cheng","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Centre, National University Health System , 5 Lower Kent Ridge Rd, Singapore 119074 , Singapore"}]},{"given":"Miriam","family":"Shanks","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Alberta, Mazankowski Alberta Heart Institute , 11220 83 Ave NW, Edmonton, AB T6G 2B7 , Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6122-8533","authenticated-orcid":false,"given":"Bogdan A","family":"Popescu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u2018Carol Davila\u2019\u2014Euroecolab, Institute of Cardiovascular Diseases \u2018Prof. Dr. C. C. Iliescu\u2019, Bulevardul Eroii Sanitari 8 , Bucure\u0219ti 050474 , Romania"}]},{"given":"Laura","family":"Galian Gay","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitari Vall d\u2019Hebr\u00f3n , Passeig de la Vall d'Hebron, 119, 08035 Barcelona , Spain"}]},{"given":"Marcin","family":"Fija\u0142kowski","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Medical University of Gdansk , Marii Sk\u0142odowskiej-Curie 3a, 80-210 Gda\u0144sk , Poland"}]},{"given":"Michael","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Centre, National University Health System , 5 Lower Kent Ridge Rd, Singapore 119074 , Singapore"},{"name":"Department of Cardiology, Khoo Teck Puat Hospital , 90 Yishun Central, Singapore 768828 , Singapore"}]},{"given":"Edgar","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Princess Alexandra Hospital, The University of Queensland , Brisbane, 199 Ipswich Rd, Woolloongabba QLD 4102 , Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-5769","authenticated-orcid":false,"given":"Nina","family":"Ajmone Marsan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Heart Lung Center , Albinusdreef 2, 2300 RC Leiden , The Netherlands"}]},{"given":"Joseph","family":"Selvanayagam","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Flinders Medical Centre , Flinders Dr, Bedford Park SA 5042, Adelaide , Australia"}]},{"given":"Fausto","family":"Pinto","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore , 10 Medical Dr, Singapore 117597 , Singapore"}]},{"given":"Jose L","family":"Zamorano","sequence":"additional","affiliation":[{"name":"Cardiology Department, Santa Maria University Hospital (CHLN), CAML, CCUL, Lisbon School of Medicine of the Universidade de Lisboa , Av. Prof. Egas Moniz MB, 1649-028 Lisboa , Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-279X","authenticated-orcid":false,"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Ram\u00f3n y Cajal , M-607, 9, 100, 28034 Madrid , Spain"}]},{"given":"Arturo","family":"Evangelista","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u2018Carol Davila\u2019\u2014Euroecolab, Institute of Cardiovascular Diseases \u2018Prof. Dr. C. C. Iliescu\u2019, Bulevardul Eroii Sanitari 8 , Bucure\u0219ti 050474 , Romania"}]},{"given":"Jeroen J","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Heart Lung Center , Albinusdreef 2, 2300 RC Leiden , The Netherlands"},{"name":"Heart Center, University of Turku and Turku University Hospital , Kiinamyllynkatu 4-8, 20521 Turku , Finland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9841-2737","authenticated-orcid":false,"given":"Victoria","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Heart Lung Center , Albinusdreef 2, 2300 RC Leiden , The Netherlands"}]}],"member":"286","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"2022111718423351600_jeab284-B1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/heartjnl-2014-307020","article-title":"The modern epidemiology of heart valve 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