{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:46:25Z","timestamp":1775907985024,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012679","name":"Montreal Heart Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>In the randomized, placebo-controlled Colchicine Cardiovascular Outcomes Trial (COLCOT) of 4745 patients enrolled within 30\u2009days after myocardial infarction (MI), low-dose colchicine (0.5\u2009mg once daily) reduced the incidence of the primary composite endpoint of cardiovascular death, resuscitated cardiac arrest, MI, stroke, or urgent hospitalization for angina leading to coronary revascularization. To assess the in-trial period and lifetime cost-effectiveness of low-dose colchicine therapy compared to placebo in post-MI patients on standard-of-care therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A multistate Markov model was developed incorporating the primary efficacy and safety results from COLCOT, as well as healthcare costs and utilities from the Canadian healthcare system perspective. All components of the primary outcome, non-cardiovascular deaths, and pneumonia were included as health states in the model as both primary and recurrent events. In the main analysis, a deterministic approach was used to estimate the incremental cost-effectiveness ratio (ICER) for the trial period (24\u2009months) and lifetime (20\u2009years). Over the in-trial period, the addition of colchicine to post-MI standard-of-care treatment decreased the mean overall per-patient costs by 47%, from $502 to $265 Canadian dollar (CAD), and increased the quality-adjusted life years (QALYs) from 1.30 to 1.34. The lifetime per-patient costs were further reduced (69%) and QALYs increased with colchicine therapy (from 8.82 to 11.68). As a result, both in-trial and lifetime ICERs indicated colchicine therapy was a dominant strategy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Cost-effectiveness analyses indicate that the addition of colchicine to standard-of-care therapy after MI is economically dominant and therefore generates cost savings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjqcco\/qcaa045","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T19:10:24Z","timestamp":1588878624000},"page":"486-495","source":"Crossref","is-referenced-by-count":64,"title":["Cost-effectiveness of low-dose colchicine after myocardial infarction in the Colchicine Cardiovascular Outcomes Trial (COLCOT)"],"prefix":"10.1093","volume":"7","author":[{"given":"Michelle","family":"Samuel","sequence":"first","affiliation":[{"name":"Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, 5000 Belanger Street, Montr\u00e9al, Qu\u00e9bec H1T 1C8, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-8983","authenticated-orcid":false,"given":"Jean-Claude","family":"Tardif","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, 5000 Belanger Street, Montr\u00e9al, Qu\u00e9bec H1T 1C8, Canada"}]},{"given":"Paul","family":"Khairy","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, 5000 Belanger Street, Montr\u00e9al, Qu\u00e9bec H1T 1C8, Canada"}]},{"given":"Fran\u00e7ois","family":"Roubille","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montpellier, INSERM, CNRS, CHU de Montpellier, Cardiology Department, CHU Arnaud de Villeneuve, 371, avenue du Doyen Gaston-Giraud, 34090 Montpellier, France"}]},{"given":"David D","family":"Waters","sequence":"additional","affiliation":[{"name":"San Francisco General Hospital, Zuckerberg San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA"}]},{"given":"Jean C","family":"Gr\u00e9goire","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, 5000 Belanger Street, Montr\u00e9al, Qu\u00e9bec H1T 1C8, Canada"}]},{"given":"Fausto J","family":"Pinto","sequence":"additional","affiliation":[{"name":"Santa Maria University Hospital (Centro Hospitalar Universit\u00e1rio Lisboa Norte), Centro Acad\u00e9mico de Medicina de Lisboa, Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Aldo P","family":"Maggioni","sequence":"additional","affiliation":[{"name":"ANMCO Research Center, Via La Marmora 34, 50121 Firenze, Italy"}]},{"given":"Rafael","family":"Diaz","sequence":"additional","affiliation":[{"name":"Estudios Clinicos Latinoamerica, Paraguay 160, 2000, Rosario, Argentina"}]},{"given":"Colin","family":"Berry","sequence":"additional","affiliation":[{"name":"University of Glasgow and NHS Glasgow Clinical Research Facility, 126 University Pl, University of Glasgow, Glasgow, G12 8TA, Scotland, UK"}]},{"given":"Wolfgang","family":"Koenig","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Lazarettstr. 36, D-80636 Munchen, Germany"}]},{"given":"Petr","family":"Ostadal","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Na Homolce Hospital, Roentgenova 2, 150 00 Prague, Czech Republic"}]},{"given":"Jose","family":"Lopez-Sendon","sequence":"additional","affiliation":[{"name":"H La Paz, IdiPaz, UAM, Ciber-CV Madrid, La Paz University Hospital, Paseo de la Castellana, 261, 28046 Madrid, Spain"}]},{"given":"Habib","family":"Gamra","sequence":"additional","affiliation":[{"name":"Fattouma Bourguiba University Hospital, 5000 Monastir, Tunisia"}]},{"given":"Ghassan S","family":"Kiwan","sequence":"additional","affiliation":[{"name":"Bellevue Medical Center, Qanater Zubayda- Mansouriyeh, Mansourieh, Metn District, Beirut, Lebanon"}]},{"given":"Marie-Pierre","family":"Dub\u00e9","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, 5000 Belanger Street, Montr\u00e9al, Qu\u00e9bec H1T 1C8, Canada"}]},{"given":"Myl\u00e8ne","family":"Provencher","sequence":"additional","affiliation":[{"name":"The Montreal Health Innovations Coordinating Center, 4100 Molson St. Suite 400 Montreal, Quebec H1Y 3N1, Canada"}]},{"given":"Andreas","family":"Orfanos","sequence":"additional","affiliation":[{"name":"The Montreal Health Innovations Coordinating Center, 4100 Molson St. Suite 400 Montreal, Quebec H1Y 3N1, Canada"}]},{"given":"Lucie","family":"Blondeau","sequence":"additional","affiliation":[{"name":"The Montreal Health Innovations Coordinating Center, 4100 Molson St. Suite 400 Montreal, Quebec H1Y 3N1, Canada"}]},{"given":"Simon","family":"Kouz","sequence":"additional","affiliation":[{"name":"Centre Hospitalier R\u00e9gional de Lanaudi\u00e8re, 1000 Sainte-Anne Blvd Saint-Charles-Borrom\u00e9e, Quebec J6E 6J2, Canada"}]},{"given":"Philippe L","family":"L\u2019Allier","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, 5000 Belanger Street, Montr\u00e9al, Qu\u00e9bec H1T 1C8, Canada"}]},{"given":"Reda","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, 5000 Belanger Street, Montr\u00e9al, Qu\u00e9bec H1T 1C8, Canada"}]},{"given":"Nadia","family":"Bouabdallaoui","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, 5000 Belanger Street, Montr\u00e9al, Qu\u00e9bec H1T 1C8, Canada"}]},{"given":"Dominic","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Logimetrix Inc., 3600 Rhodes Drive Windsor, Ontario N8W 5A4, Canada"}]},{"given":"Marie-Claude","family":"Guertin","sequence":"additional","affiliation":[{"name":"The Montreal Health Innovations Coordinating Center, 4100 Molson St. Suite 400 Montreal, Quebec H1Y 3N1, Canada"}]},{"given":"Jacques","family":"Lelorier","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, 5000 Belanger Street, Montr\u00e9al, Qu\u00e9bec H1T 1C8, Canada"},{"name":"Centre de recherche du Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, 900 St Denis St Montreal, Quebec H2X 0A9, 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