{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:00:17Z","timestamp":1776952817594,"version":"3.51.4"},"reference-count":189,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project\u2014a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Research priorities include: genetic\/epigenetic factors, brain\u2013periphery communication, and environmental influences. Key therapeutic areas include innovative approaches for monogenic disorders, incretin mimetics, dual receptor agonists, microbiome analysis, and improved behavioural interventions. For type 1 diabetes, priorities focus on early detection, insulin delivery systems, and disease-modifying therapies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into diabetes and obesity pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of metabolic disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvaf065","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T09:02:06Z","timestamp":1760691726000},"page":"ii47-ii71","source":"Crossref","is-referenced-by-count":2,"title":["EndoCompass project: research roadmap for diabetes, obesity, and metabolism"],"prefix":"10.1093","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4055-5233","authenticated-orcid":false,"given":"Chantal","family":"Mathieu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, UZ Gasthuisberg, Katholieke Universiteit Leuven , 3000 Leuven ,","place":["Belgium"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3703-0011","authenticated-orcid":false,"given":"Manuela","family":"Meireles","sequence":"additional","affiliation":[{"name":"European Association for the Study of Diabetes , 40591 D\u00fcsseldorf ,","place":["Germany"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-3110","authenticated-orcid":false,"given":"Uberto","family":"Pagotto","sequence":"additional","affiliation":[{"name":"Division of Endocrionology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universtaria di Bologna; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, 40138 Bologna ,","place":["Italy"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-8430","authenticated-orcid":false,"given":"Martin","family":"Wabitsch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm , 89075 Ulm ,","place":["Germany"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-7470","authenticated-orcid":false,"given":"Indraneel","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Manchester University NHS Foundation Trust , M13 9 WL, Manchester ,","place":["United Kingdom"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-0553","authenticated-orcid":false,"given":"Alberto","family":"Bartolom\u00e9","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas Sols-Morreale (CSIC\/UAM) , 28029 Madrid ,","place":["Spain"]},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas , 28029 Madrid ,","place":["Spain"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0273-4732","authenticated-orcid":false,"given":"Tadej","family":"Battelino","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana , 1000 Ljubljana ,","place":["Slovenia"]},{"name":"Department of Endocrinology, Diabetes and Metabolic Diseases, University Children\u2019s Hospital, UMC, University Medical Centre Ljubljana , 1000 Ljubljana ,","place":["Slovenia"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8556-1075","authenticated-orcid":false,"given":"Julia","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, University Hospital Basel , 4031 Basel, BS ,","place":["Switzerland"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-1495","authenticated-orcid":false,"given":"Francesco","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Chieti , 66100 Chieti ,","place":["Italy"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-8087","authenticated-orcid":false,"given":"Diva D","family":"De Leon","sequence":"additional","affiliation":[{"name":"Congenital Hyperinsulinism Center, Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, University of Pennsylvania , 19104 Philadelphia, Pennsylvania ,","place":["United States"]},{"name":"Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania , 19104 Philadelphia, Pennsylvania ,","place":["United States"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9201-2145","authenticated-orcid":false,"given":"Klemen","family":"Dov\u010d","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana , 1000 Ljubljana ,","place":["Slovenia"]},{"name":"Department of Endocrinology, Diabetes and Metabolic Diseases, University Children\u2019s Hospital, UMC, University Medical Centre Ljubljana , 1000 Ljubljana ,","place":["Slovenia"]}]},{"given":"Marwan","family":"El Ghoch","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences , University of Modena and Reggio Emilia ,","place":["Italy"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8885-3056","authenticated-orcid":false,"given":"Alfonso","family":"Galderisi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yale University , 06510 New Haven, Connecticut ,","place":["United States"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4397-4126","authenticated-orcid":false,"given":"Evelien","family":"Gevers","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London , E1 4NS London ,","place":["United Kingdom"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9111-4561","authenticated-orcid":false,"given":"Pieter","family":"Gillard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospitals Leuven , 3000 Leuven ,","place":["Belgium"]}]},{"given":"Belma","family":"Haliloglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetology, Marmara University Faculty of Medicine , 34722 \u0130stanbul ,","place":["Turkey"]}]},{"given":"Henrike","family":"Hoermann","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics, Neonatology and Paediatric Cardiology, University Children's Hospital D\u00fcsseldorf , 40225 D\u00fcsseldorf ,","place":["Germany"]}]},{"given":"Boris","family":"Mankovsky","sequence":"additional","affiliation":[{"name":"Institute of Gerontology , Kyiv, 04114 ,","place":["Ukraine"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4822-4113","authenticated-orcid":false,"given":"Jonathan","family":"Mertens","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Medicine and Paediatrics, Universiteit Antwerpen , 2000 Antwerp, Flanders ,","place":["Belgium"]},{"name":"Department of Endocrinology, Diabetology and Metabolism , Antwerp University Hospital, 2650 Edegem ,","place":["Belgium"]}]},{"given":"Klaus","family":"Mohnike","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Otto von Guericke Universitat Magdeburg , 39016 Magdeburg, Sachsen-Anhalt ,","place":["Germany"]}]},{"given":"Richard","family":"Oram","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Clinical Science, University of Exeter Medical School , EX4 4QJ Exeter ,","place":["United Kingdom"]}]},{"given":"Tai","family":"Pasquini","sequence":"additional","affiliation":[{"name":"Congenital Hyperinsulinism International , 07028 Glen Ridge, NJ ,","place":["United States"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-8585","authenticated-orcid":false,"given":"Ewan","family":"Pearson","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology, Ninewells Hospital , DD1 9SY Dundee ,","place":["United Kingdom"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3554-0405","authenticated-orcid":false,"given":"Thomas R","family":"Pieber","sequence":"additional","affiliation":[{"name":"Internal Medicine, Medical University of Graz , 8010 Graz ,","place":["Austria"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4838-689X","authenticated-orcid":false,"given":"Snezana","family":"Polovina","sequence":"additional","affiliation":[{"name":"Clinic for Endocrinology, Diabetes, and Metabolic Diseases, University Clinical Center of Serbia , 11000 Belgrade ,","place":["Serbia"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5396-6936","authenticated-orcid":false,"given":"Julie","family":"Raskin","sequence":"additional","affiliation":[{"name":"Congenital Hyperinsulinism International , 07028 Glen Ridge, NJ ,","place":["United States"]}]},{"given":"Marcia","family":"Roeper","sequence":"additional","affiliation":[{"name":"Department of General Paediatrics, Neonatology and Paediatric Cardiology, University Children's Hospital D\u00fcsseldorf , 40225 D\u00fcsseldorf ,","place":["Germany"]},{"name":"Department for paediatric endocrinology and diabetology, Charit\u00e9 Universit\u00e4tsmedizin Berlin , 10117 Berlin ,","place":["Germany"]}]},{"given":"Lisa","family":"Ruck","sequence":"additional","affiliation":[{"name":"Department for paediatric endocrinology and diabetology, Charit\u00e9 Universit\u00e4tsmedizin Berlin , 10117 Berlin ,","place":["Germany"]}]},{"given":"Maria","family":"Salomon Estebanez","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Royal Manchester Children's Hospital , M13 9WL Manchester ,","place":["United Kingdom"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-1131","authenticated-orcid":false,"given":"Tsvetalina","family":"Tankova","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Medical University - Sofia , 1431 Sofia ,","place":["Bulgaria"]}]},{"given":"Paul","family":"Thornton","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Cook Children's Medical Center , Fort Worth, TX 76104 ,","place":["United States"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-4913","authenticated-orcid":false,"given":"Elisabeth F C","family":"van Rossum","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Obesity Center CGG, Erasmus MC , 3000 CA Rotterdam ,","place":["Netherlands"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-4105","authenticated-orcid":false,"given":"Rade","family":"Vukovic","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Belgrade , 10117 Belgrade ,","place":["Serbia"]},{"name":"Department of Endocrinology, Mother and Child Health Care Institute of Serbia \"Dr dr Vukan \u010cupi\u0107\" , 11070 Belgrade ,","place":["Serbia"]}]},{"given":"Chris","family":"Worth","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Royal Manchester Children's Hospital , M13 9WL Manchester ,","place":["United Kingdom"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-7607","authenticated-orcid":false,"given":"Agnieszka","family":"Zachurzok","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia , 41-800 Zabrze ,","place":["Poland"]}]}],"member":"286","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"issue":"3","key":"2025101705020449700_lvaf065-B1","doi-asserted-by":"publisher","first-page":"642","DOI":"10.2337\/dc21-2056","article-title":"Improvements in awareness and testing have led to a threefold increase over 10 years in the identification of monogenic diabetes in the U.K","volume":"45","author":"Pang","year":"2022","journal-title":"Diabetes Care"},{"issue":"1","key":"2025101705020449700_lvaf065-B2","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s43856-023-00369-8","article-title":"The use of precision diagnostics for monogenic diabetes: a systematic review and expert opinion","volume":"3","author":"Murphy","year":"2023","journal-title":"Commun Med (Lond)"},{"issue":"1","key":"2025101705020449700_lvaf065-B3","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3390\/ijms23010501","article-title":"Stem cell-derived \u03b2 cells: a versatile research platform to interrogate the genetic basis of \u03b2 cell dysfunction","volume":"23","author":"Bartolom\u00e9","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2025101705020449700_lvaf065-B4","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1016\/j.stemcr.2018.11.006","article-title":"\u03b2 cell replacement after gene editing of a neonatal diabetes-causing mutation at the insulin locus","volume":"11","author":"Ma","year":"2018","journal-title":"Stem Cell Reports"},{"key":"2025101705020449700_lvaf065-B5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.metabol.2018.10.007","article-title":"Genetics and epigenetics in obesity","volume":"92","author":"Rohde","year":"2019","journal-title":"Metabolism"},{"key":"2025101705020449700_lvaf065-B6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12881-015-0174-1","article-title":"Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women","volume":"16","author":"Houde","year":"2015","journal-title":"BMC Med Genet"},{"issue":"3","key":"2025101705020449700_lvaf065-B7","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.cmet.2016.08.001","article-title":"Interindividual variation in DNA methylation at a putative POMC metastable epiallele is associated with obesity","volume":"24","author":"K\u00fchnen","year":"2016","journal-title":"Cell Metab"},{"issue":"5","key":"2025101705020449700_lvaf065-B8","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.cmet.2019.03.009","article-title":"Epigenetics in human obesity and type 2 diabetes","volume":"29","author":"Ling","year":"2019","journal-title":"Cell Metab"},{"issue":"5","key":"2025101705020449700_lvaf065-B9","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s11154-023-09804-6","article-title":"Genetics and epigenetics in the obesity phenotyping scenario","volume":"24","author":"Trang","year":"2023","journal-title":"Rev Endocr Metab Disord"},{"issue":"3","key":"2025101705020449700_lvaf065-B10","doi-asserted-by":"publisher","first-page":"e711","DOI":"10.1542\/peds.2011-0155","article-title":"Monozygotic twins discordant for ROHHAD phenotype","volume":"128","author":"Patwari","year":"2011","journal-title":"Pediatrics"},{"key":"2025101705020449700_lvaf065-B11","doi-asserted-by":"publisher","first-page":"116947","DOI":"10.1016\/j.bone.2023.116947","article-title":"The global ALPL gene variant classification project: dedicated to deciphering variants","volume":"178","author":"Farman","year":"2024","journal-title":"Bone"},{"issue":"3","key":"2025101705020449700_lvaf065-B12","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/s0016-5085(98)70540-2","article-title":"Brain-gut axis in health and disease","volume":"114","author":"Aziz","year":"1998","journal-title":"Gastroenterology"},{"issue":"18","key":"2025101705020449700_lvaf065-B13","doi-asserted-by":"publisher","first-page":"7143","DOI":"10.1523\/JNEUROSCI.23-18-07143.2003","article-title":"Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter","volume":"23","author":"Liu","year":"2003","journal-title":"J Neurosci"},{"issue":"5","key":"2025101705020449700_lvaf065-B14","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/PSY.0b013e31821a196f","article-title":"Leptin as a neuroactive agent","volume":"73","author":"Zupancic","year":"2011","journal-title":"Psychosom Med"},{"key":"2025101705020449700_lvaf065-B15","doi-asserted-by":"publisher","first-page":"101175","DOI":"10.1016\/j.molmet.2021.101175","article-title":"The gut-brain axis: identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders","volume":"46","author":"Richards","year":"2021","journal-title":"Mol Metab"},{"issue":"5","key":"2025101705020449700_lvaf065-B16","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2220\/biomedres.41.199","article-title":"Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system","volume":"41","author":"Kuwahara","year":"2020","journal-title":"Biomed Res"},{"issue":"4","key":"2025101705020449700_lvaf065-B17","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol Rev"},{"key":"2025101705020449700_lvaf065-B18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3389\/fnins.2013.00181","article-title":"The central GLP-1: implications for food and drug reward","volume":"7","author":"Skibicka","year":"2013","journal-title":"Front Neurosci"},{"key":"2025101705020449700_lvaf065-B19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fendo.2014.00058","article-title":"Peptides and food intake","volume":"5","author":"Sobrino Crespo","year":"2014","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2025101705020449700_lvaf065-B20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.mce.2015.02.017","article-title":"Brain GLP-1 and insulin sensitivity","volume":"418","author":"Sandoval","year":"2015","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"2025101705020449700_lvaf065-B21","doi-asserted-by":"publisher","first-page":"e12684","DOI":"10.1111\/jne.12684","article-title":"The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system","volume":"31","author":"Heiss","year":"2019","journal-title":"J Neuroendocrinol"},{"issue":"4","key":"2025101705020449700_lvaf065-B22","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"4","key":"2025101705020449700_lvaf065-B23","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1053\/j.gastro.2016.10.046","article-title":"The vagus nerve in appetite regulation, mood, and intestinal inflammation","volume":"152","author":"Browning","year":"2017","journal-title":"Gastroenterology"},{"issue":"1","key":"2025101705020449700_lvaf065-B24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.neuropharm.2011.10.008","article-title":"The role of the gut\/brain axis in modulating food intake","volume":"63","author":"Sam","year":"2012","journal-title":"Neuropharmacology"},{"issue":"7424","key":"2025101705020449700_lvaf065-B25","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nature11705","article-title":"Central nervous system control of metabolism","volume":"491","author":"Myers","year":"2012","journal-title":"Nature"},{"issue":"1","key":"2025101705020449700_lvaf065-B26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1530\/JOE-15-0139","article-title":"Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation","volume":"226","author":"Naznin","year":"2015","journal-title":"J Endocrinol"},{"issue":"6","key":"2025101705020449700_lvaf065-B27","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/ncpendmet0196","article-title":"Drug insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications","volume":"2","author":"Brennan","year":"2006","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"2025101705020449700_lvaf065-B28","doi-asserted-by":"publisher","first-page":"604179","DOI":"10.3389\/fimmu.2020.604179","article-title":"The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology","volume":"11","author":"Rutsch","year":"2020","journal-title":"Front Immunol"},{"issue":"7","key":"2025101705020449700_lvaf065-B29","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1136\/gutjnl-2017-314050","article-title":"Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit","volume":"67","author":"Li","year":"2018","journal-title":"Gut"},{"issue":"10","key":"2025101705020449700_lvaf065-B30","doi-asserted-by":"publisher","first-page":"e143772","DOI":"10.1172\/JCI143772","article-title":"Roles for the gut microbiota in regulating neuronal feeding circuits","volume":"131","author":"Yu","year":"2021","journal-title":"J Clin Invest"},{"issue":"12","key":"2025101705020449700_lvaf065-B31","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1111\/j.1365-2826.2011.02226.x","article-title":"Understanding postprandial glucose clearance by peripheral organs: the role of the hepatic parasympathetic system","volume":"23","author":"Fernandes","year":"2011","journal-title":"J Neuroendocrinol"},{"issue":"18","key":"2025101705020449700_lvaf065-B32","doi-asserted-by":"publisher","first-page":"10028","DOI":"10.3390\/ijms221810028","article-title":"The role of gut microbiota and gut-brain interplay in selected diseases of the central nervous system","volume":"22","author":"Doroszkiewicz","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2025101705020449700_lvaf065-B33","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3390\/nu8050281","article-title":"Gut microbiota and metabolic health: the potential beneficial effects of a medium chain triglyceride diet in obese individuals","volume":"8","author":"Rial","year":"2016","journal-title":"Nutrients"},{"issue":"4","key":"2025101705020449700_lvaf065-B34","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1089\/met.2018.0088","article-title":"The role of glucagon-like peptide-1 in energy homeostasis","volume":"17","author":"Salehi","year":"2019","journal-title":"Metab Syndr Relat Disord"},{"issue":"5","key":"2025101705020449700_lvaf065-B35","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1007\/s11695-017-2595-8","article-title":"Impact of bariatric surgery on metabolic and gut microbiota profile: a systematic review and meta-analysis","volume":"27","author":"Magouliotis","year":"2017","journal-title":"Obes Surg"},{"issue":"9","key":"2025101705020449700_lvaf065-B36","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1016\/j.cmet.2021.07.018","article-title":"Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin","volume":"33","author":"B\u00e4ckdahl","year":"2021","journal-title":"Cell Metab"},{"issue":"11","key":"2025101705020449700_lvaf065-B37","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3390\/nu16111629","article-title":"Obesity, dietary patterns, and hormonal balance modulation: gender-specific impacts","volume":"16","author":"Mazza","year":"2024","journal-title":"Nutrients"},{"issue":"10","key":"2025101705020449700_lvaf065-B38","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1038\/s41366-020-0644-1","article-title":"Child neurobiology impacts success in family-based behavioral treatment for children with obesity","volume":"44","author":"Schur","year":"2020","journal-title":"Int J Obes (Lond)"},{"issue":"1","key":"2025101705020449700_lvaf065-B39","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1479-5868-8-98","article-title":"Systematic review of sedentary behaviour and health indicators in school-aged children and youth","volume":"8","author":"Tremblay","year":"2011","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"8","key":"2025101705020449700_lvaf065-B40","doi-asserted-by":"publisher","first-page":"bvad090","DOI":"10.1210\/jendso\/bvad090","article-title":"Physical activity, sedentary behavior, and type 2 diabetes: Mendelian randomization analysis","volume":"7","author":"Yuan","year":"2023","journal-title":"J Endocr Soc"},{"issue":"12","key":"2025101705020449700_lvaf065-B41","doi-asserted-by":"publisher","first-page":"0300074","DOI":"10.1371\/journal.pone.0300074","article-title":"Sedentary behavior, physical activity, sleep duration and obesity risk: Mendelian randomization study","volume":"19","author":"Chen","year":"2024","journal-title":"PLoS One"},{"issue":"10","key":"2025101705020449700_lvaf065-B42","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.3390\/nu15102286","article-title":"Are emotional eating and other eating behaviors the missing link in the relationship between inadequate sleep and obesity? A systematic review","volume":"15","author":"Zer\u00f3n-Rugerio","year":"2023","journal-title":"Nutrients"},{"issue":"5","key":"2025101705020449700_lvaf065-B43","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.3390\/nu15051173","article-title":"The association of emotional eating with overweight\/obesity, depression, anxiety\/stress, and dietary patterns: a review of the current clinical evidence","volume":"15","author":"Dakanalis","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"2025101705020449700_lvaf065-B44","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1146\/annurev-psych-010418-102936","article-title":"Stress and obesity","volume":"70","author":"Tomiyama","year":"2019","journal-title":"Annu Rev Psychol"},{"issue":"3","key":"2025101705020449700_lvaf065-B45","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.3390\/ijerph20032722","article-title":"Emotional eating interventions for adults living with overweight or obesity: a systematic review and meta-analysis","volume":"20","author":"Smith","year":"2023","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"2025101705020449700_lvaf065-B46","first-page":"146","article-title":"The impact of air pollution to obesity","volume":"41","author":"Simkova","year":"2020","journal-title":"Neuro Endocrinol Lett"},{"issue":"10","key":"2025101705020449700_lvaf065-B47","doi-asserted-by":"publisher","first-page":"8870","DOI":"10.3390\/ijms24108870","article-title":"Environmental pollution and the risk of developing metabolic disorders: obesity and diabetes","volume":"24","author":"Khalil","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"11","key":"2025101705020449700_lvaf065-B48","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nrendo.2015.163","article-title":"Endocrine disruptors and obesity","volume":"11","author":"Heindel","year":"2015","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"2025101705020449700_lvaf065-B49","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s13679-017-0240-4","article-title":"Endocrine disruptors and obesity","volume":"6","author":"Darbre","year":"2017","journal-title":"Curr Obes Rep"},{"issue":"3","key":"2025101705020449700_lvaf065-B50","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrendo.2016.186","article-title":"Early-life exposure to EDCs: role in childhood obesity and neurodevelopment","volume":"13","author":"Braun","year":"2017","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"2025101705020449700_lvaf065-B51","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S2213-8587(21)00145-5","article-title":"European Commission classifies obesity as a chronic disease","volume":"9","author":"Burki","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"22","key":"2025101705020449700_lvaf065-B52","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1001\/jama.2016.7602","article-title":"Association of pharmacological treatments for obesity with weight loss and adverse events: a systematic review and meta-analysis","volume":"315","author":"Khera","year":"2016","journal-title":"JAMA"},{"key":"2025101705020449700_lvaf065-B53","author":"EMA"},{"issue":"11","key":"2025101705020449700_lvaf065-B54","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1056\/NEJMoa2032183","article-title":"Once-weekly semaglutide in adults with overweight or obesity","volume":"384","author":"Wilding","year":"2021","journal-title":"N Engl J Med"},{"issue":"3","key":"2025101705020449700_lvaf065-B55","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1056\/NEJMoa2206038","article-title":"Tirzepatide once weekly for the treatment of obesity","volume":"387","author":"Jastreboff","year":"2022","journal-title":"N Engl J Med"},{"issue":"6","key":"2025101705020449700_lvaf065-B56","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1056\/NEJMoa2301972","article-title":"Triple-hormone-receptor agonist retatrutide for obesity\u2014a phase 2 trial","volume":"389","author":"Jastreboff","year":"2023","journal-title":"N Engl J Med"},{"issue":"1","key":"2025101705020449700_lvaf065-B57","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1172\/JCI116186","article-title":"Preserved incretin activity of glucagon-like peptide 1 [7\u201336 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus","volume":"91","author":"Nauck","year":"1993","journal-title":"J Clin Invest"},{"issue":"S3","key":"2025101705020449700_lvaf065-B58","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/dom.14496","article-title":"The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: a pathophysiological update","volume":"23","author":"Nauck","year":"2021","journal-title":"Diabetes Obes Metab"},{"issue":"2","key":"2025101705020449700_lvaf065-B59","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/s42255-023-00966-w","article-title":"A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings","volume":"6","author":"V\u00e9niant","year":"2024","journal-title":"Nat Metab"},{"issue":"6","key":"2025101705020449700_lvaf065-B60","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/s42255-023-00812-z","article-title":"Gut hormone co-agonists for the treatment of obesity: from bench to bedside","volume":"5","author":"Nogueiras","year":"2023","journal-title":"Nat Metab"},{"issue":"10403","key":"2025101705020449700_lvaf065-B61","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S0140-6736(23)01185-6","article-title":"Oral semaglutide 50\u2005mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"402","author":"Knop","year":"2023","journal-title":"Lancet"},{"issue":"10","key":"2025101705020449700_lvaf065-B62","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1056\/NEJMoa2302392","article-title":"Daily oral GLP-1 receptor agonist orforglipron for adults with obesity","volume":"389","author":"Wharton","year":"2023","journal-title":"N Engl J Med"},{"issue":"3","key":"2025101705020449700_lvaf065-B63","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1124\/pr.115.010629","article-title":"Amylin: pharmacology, physiology, and clinical potential","volume":"67","author":"Hay","year":"2015","journal-title":"Pharmacol Rev"},{"issue":"10403","key":"2025101705020449700_lvaf065-B64","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/S0140-6736(23)01163-7","article-title":"Efficacy and safety of co-administered once-weekly cagrilintide 2\u00b74\u2005mg with once-weekly semaglutide 2\u00b74\u2005mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial","volume":"402","author":"Frias","year":"2023","journal-title":"Lancet"},{"key":"2025101705020449700_lvaf065-B65","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.peptides.2017.07.011","article-title":"Differential expression of glucagon-like peptide-2 (GLP-2) is involved in pancreatic islet cell adaptations to stress and beta-cell survival","volume":"95","author":"Khan","year":"2017","journal-title":"Peptides"},{"key":"2025101705020449700_lvaf065-B66","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41366-024-01473-y","article-title":"What is the pipeline for future medications for obesity?","volume":"49","author":"Melson","year":"2024","journal-title":"Int J Obes (Lond)"},{"issue":"1","key":"2025101705020449700_lvaf065-B67","doi-asserted-by":"publisher","first-page":"e211376","DOI":"10.1001\/jamanetworkopen.2020.33457","article-title":"Effect of bimagrumab vs placebo on body fat mass among adults with type 2 diabetes and obesity: a phase 2 randomized clinical trial","volume":"4","author":"Heymsfield","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"2","key":"2025101705020449700_lvaf065-B68","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cmet.2022.12.011","article-title":"Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist","volume":"35","author":"Benichou","year":"2023","journal-title":"Cell Metab"},{"issue":"4","key":"2025101705020449700_lvaf065-B69","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/s42255-021-00363-1","article-title":"A genetic map of the mouse dorsal vagal complex and its role in obesity","volume":"3","author":"Ludwig","year":"2021","journal-title":"Nat Metab"},{"issue":"3","key":"2025101705020449700_lvaf065-B70","doi-asserted-by":"publisher","first-page":"580","DOI":"10.3390\/jcm11030580","article-title":"Fibroblast growth factor 21 facilitates the homeostatic control of feeding behavior","volume":"11","author":"Wu","year":"2022","journal-title":"J Clin Med"},{"issue":"11","key":"2025101705020449700_lvaf065-B71","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.2337\/db10-0193","article-title":"Obesity is a fibroblast growth factor 21 (FGF21)-resistant state","volume":"59","author":"Fisher","year":"2010","journal-title":"Diabetes"},{"key":"2025101705020449700_lvaf065-B72","doi-asserted-by":"publisher","first-page":"1253675","DOI":"10.3389\/fendo.2023.1253675","article-title":"Editorial: FGF21 as a therapeutic target for obesity and insulin resistance: from rodent models to humans","volume":"14","author":"De Sousa-Coelho","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"2025101705020449700_lvaf065-B73","doi-asserted-by":"publisher","first-page":"e8791","DOI":"10.15252\/emmm.201708791","article-title":"FGF21 gene therapy as treatment for obesity and insulin resistance","volume":"10","author":"Jimenez","year":"2018","journal-title":"EMBO Mol Med"},{"issue":"11","key":"2025101705020449700_lvaf065-B74","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.1002\/oby.23902","article-title":"Novel cannabinoid receptor 1 inverse agonist CRB-913 enhances efficacy of tirzepatide, semaglutide, and liraglutidein the diet-induced obesity mouse model","volume":"31","author":"Morningstar","year":"2023","journal-title":"Obesity (Silver Spring)"},{"issue":"2","key":"2025101705020449700_lvaf065-B75","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/dom.15353","article-title":"Effects of CB1R inverse agonist, INV-202, in patients with features of metabolic syndrome. A randomized, placebo-controlled, double-blind phase 1b study","volume":"26","author":"Crater","year":"2024","journal-title":"Diabetes Obes Metab"},{"issue":"3","key":"2025101705020449700_lvaf065-B76","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1042\/BCJ20190463","article-title":"UCP1-independent thermogenesis","volume":"477","author":"Roesler","year":"2020","journal-title":"Biochem J"},{"issue":"1","key":"2025101705020449700_lvaf065-B77","doi-asserted-by":"publisher","first-page":"30030","DOI":"10.1038\/srep30030","article-title":"Proteomic analysis of human brown adipose tissue reveals utilization of coupled and uncoupled energy expenditure pathways","volume":"6","author":"M\u00fcller","year":"2016","journal-title":"Sci Rep"},{"issue":"9","key":"2025101705020449700_lvaf065-B78","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1016\/j.cmet.2024.07.005","article-title":"Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes","volume":"36","author":"Wang","year":"2024","journal-title":"Cell Metab"},{"issue":"2","key":"2025101705020449700_lvaf065-B79","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1210\/endrev\/bnac015","article-title":"Brown adipose tissue-A translational perspective","volume":"44","author":"Carpentier","year":"2023","journal-title":"Endocr Rev"},{"issue":"9","key":"2025101705020449700_lvaf065-B80","doi-asserted-by":"publisher","first-page":"103717","DOI":"10.1016\/j.drudis.2023.103717","article-title":"UCP1 activation: hottest target in the thermogenesis pathway to treat obesity using molecules of synthetic and natural origin","volume":"28","author":"Jagtap","year":"2023","journal-title":"Drug Discov Today"},{"issue":"10403","key":"2025101705020449700_lvaf065-B81","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/S0140-6736(23)01233-3","article-title":"The pursuit of optimal semaglutide dosing in type 2 diabetes continues","volume":"402","author":"Sherrill","year":"2023","journal-title":"Lancet"},{"key":"2025101705020449700_lvaf065-B82","doi-asserted-by":"publisher","first-page":"709893","DOI":"10.1155\/2012\/709893","article-title":"Small molecule drug discovery at the glucagon-like peptide-1 receptor","volume":"2012","author":"Willard","year":"2012","journal-title":"Exp Diabetes Res"},{"issue":"10","key":"2025101705020449700_lvaf065-B83","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1056\/NEJMe2307285","article-title":"Next chapter for weight control\u2014small-molecule GLP-1 receptor agonists?","volume":"389","author":"Abel","year":"2023","journal-title":"N Engl J Med"},{"key":"2025101705020449700_lvaf065-B84","doi-asserted-by":"publisher","first-page":"101762","DOI":"10.1016\/j.molmet.2023.101762","article-title":"Discovery of ecnoglutide\u2014a novel, long-acting, cAMP-biased glucagon-like peptide-1 (GLP-1) analog","volume":"75","author":"Guo","year":"2023","journal-title":"Mol Metab"},{"issue":"17","key":"2025101705020449700_lvaf065-B85","doi-asserted-by":"publisher","first-page":"140532","DOI":"10.1172\/jci.insight.140532","article-title":"Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist","volume":"5","author":"Willard","year":"2020","journal-title":"JCI Insight"},{"issue":"10278","key":"2025101705020449700_lvaf065-B86","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/S0140-6736(21)00213-0","article-title":"Semaglutide 2\u00b74\u2005mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial","volume":"397","author":"Davies","year":"2021","journal-title":"Lancet"},{"issue":"4","key":"2025101705020449700_lvaf065-B87","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.jhep.2023.05.013","article-title":"A phase IIa active-comparator-controlled study to evaluate the efficacy and safety of efinopegdutide in patients with non-alcoholic fatty liver disease","volume":"79","author":"Romero-G\u00f3mez","year":"2023","journal-title":"J Hepatol"},{"issue":"12","key":"2025101705020449700_lvaf065-B88","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1056\/NEJMoa2306963","article-title":"Semaglutide in patients with heart failure with preserved ejection fraction and obesity","volume":"389","author":"Kosiborod","year":"2023","journal-title":"N Engl J Med"},{"issue":"2","key":"2025101705020449700_lvaf065-B89","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s13679-024-00552-5","article-title":"Behavioral lifestyle interventions for weight loss in overweight or obese patients with type 2 diabetes: a systematic review of the literature","volume":"13","author":"Gostoli","year":"2024","journal-title":"Curr Obes Rep"},{"issue":"3","key":"2025101705020449700_lvaf065-B90","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s11695-010-0335-4","article-title":"Relationship between obesity and diabetes in a US adult population: findings from the National Health and Nutrition Examination Survey, 1999\u20132006","volume":"21","author":"Nguyen","year":"2011","journal-title":"Obes Surg"},{"issue":"8","key":"2025101705020449700_lvaf065-B91","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/j.jada.2009.05.016","article-title":"Action for Health in Diabetes (Look AHEAD) trial: baseline evaluation of selected nutrients and food group intake","volume":"109","author":"Vitolins","year":"2009","journal-title":"J Am Diet Assoc"},{"issue":"12","key":"2025101705020449700_lvaf065-B92","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.2337\/diacare.25.12.2165","article-title":"The Diabetes Prevention Program (DPP): description of lifestyle intervention","volume":"25","author":"Diabetes Prevention Program (DPP) Research Group","year":"2002","journal-title":"Diabetes Care"},{"key":"2025101705020449700_lvaf065-B93","first-page":"512","volume-title":"Eating Disorders and Obesity: A Comprehensive Handbook","author":"Butryn","year":"2017","edition":"3rd ed"},{"issue":"1","key":"2025101705020449700_lvaf065-B94","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12966-016-0436-0","article-title":"Behaviour change techniques targeting both diet and physical activity in type 2 diabetes: a systematic review and meta-analysis","volume":"14","author":"Cradock","year":"2017","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"4","key":"2025101705020449700_lvaf065-B95","doi-asserted-by":"publisher","first-page":"S66","DOI":"10.1016\/j.jada.2008.01.026","article-title":"Implications of the diabetes prevention program and Look AHEAD clinical trials for lifestyle interventions","volume":"108","author":"Delahanty","year":"2008","journal-title":"J Am Diet Assoc"},{"issue":"2","key":"2025101705020449700_lvaf065-B96","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.15586\/jptcp.v26i2.599","article-title":"Challenges and new directions in obesity management: lifestyle modification programmes, pharmacotherapy and bariatric surgery","volume":"26","author":"El Ghoch","year":"2019","journal-title":"J Popul Ther Clin Pharmacol"},{"issue":"1","key":"2025101705020449700_lvaf065-B97","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s41043-024-00516-4","article-title":"What could be the reasons for not losing weight even after following a weight loss program?","volume":"43","author":"Dabas","year":"2024","journal-title":"J Health Popul Nutr"},{"issue":"9","key":"2025101705020449700_lvaf065-B98","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.jand.2015.02.031","article-title":"Lifestyle weight-loss intervention outcomes in overweight and obese adults with type 2 diabetes: a systematic review and meta-analysis of randomized clinical trials","volume":"115","author":"Franz","year":"2015","journal-title":"J Acad Nutr Diet"},{"issue":"2","key":"2025101705020449700_lvaf065-B99","doi-asserted-by":"publisher","first-page":"CD004095","DOI":"10.1002\/14651858.CD004095.pub2","article-title":"Long-term non-pharmacologic weight loss interventions for adults with type 2 diabetes","volume":"2005","author":"Norris","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"2025101705020449700_lvaf065-B100","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/dom.12430","article-title":"Effectiveness of lifestyle-based weight loss interventions for adults with type 2 diabetes: a systematic review and meta-analysis","volume":"17","author":"Terranova","year":"2015","journal-title":"Diabetes Obes Metab"},{"key":"2025101705020449700_lvaf065-B101","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jclinepi.2018.11.030","article-title":"Systematic reviews of clinical practice guidelines: a methodological guide","volume":"108","author":"Johnston","year":"2019","journal-title":"J Clin Epidemiol"},{"key":"2025101705020449700_lvaf065-B102","doi-asserted-by":"publisher","first-page":"101","DOI":"10.2147\/PRBM.S40460","article-title":"Major factors for facilitating change in behavioral strategies to reduce obesity","volume":"6","author":"Dalle Grave","year":"2013","journal-title":"Psychol Res Behav Manag"},{"issue":"1","key":"2025101705020449700_lvaf065-B103","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1159\/000496183","article-title":"European practical and patient-centred guidelines for adult obesity management in primary care","volume":"12","author":"Durrer Schutz","year":"2019","journal-title":"Obes Facts"},{"key":"2025101705020449700_lvaf065-B104","doi-asserted-by":"publisher","first-page":"1202545","DOI":"10.3389\/fpubh.2023.1202545","article-title":"Strategies to improve the implementation of intensive lifestyle interventions for obesity","volume":"11","author":"Finn","year":"2023","journal-title":"Front Public Health"},{"issue":"1","key":"2025101705020449700_lvaf065-B105","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12967-024-04953-x","article-title":"Adaptation of a standardized lifestyle intervention to maximize health outcomes in adolescent metabolic and bariatric surgery patients","volume":"22","author":"Misserian","year":"2024","journal-title":"J Transl Med"},{"key":"2025101705020449700_lvaf065-B106","doi-asserted-by":"publisher","first-page":"100638","DOI":"10.1016\/j.conctc.2020.100638","article-title":"Effectiveness of a web-based real-life weight management program: study design, methods, and participants' baseline characteristics","volume":"19","author":"Suojanen","year":"2020","journal-title":"Contemp Clin Trials Commun"},{"issue":"1","key":"2025101705020449700_lvaf065-B107","doi-asserted-by":"publisher","first-page":"478","DOI":"10.3390\/ijerph20010478","article-title":"Professional competence and its effect on the implementation of healthcare 4.0 technologies: scoping review and future research directions","volume":"20","author":"Jose","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"2025101705020449700_lvaf065-B108","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/193229680900300122","article-title":"Recent advances in internet-delivered, evidence-based weight control programs for adults","volume":"3","author":"Krukowski","year":"2009","journal-title":"J Diabetes Sci Technol"},{"issue":"6","key":"2025101705020449700_lvaf065-B109","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41591-021-01349-y","article-title":"Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort","volume":"27","author":"Wade","year":"2021","journal-title":"Nat Med"},{"issue":"12","key":"2025101705020449700_lvaf065-B110","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1056\/NEJMoa022050","article-title":"Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene","volume":"348","author":"Farooqi","year":"2003","journal-title":"N Engl J Med"},{"issue":"3","key":"2025101705020449700_lvaf065-B111","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1056\/NEJMoa063988","article-title":"Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor","volume":"356","author":"Farooqi","year":"2007","journal-title":"N Engl J Med"},{"issue":"5","key":"2025101705020449700_lvaf065-B112","doi-asserted-by":"publisher","first-page":"E757","DOI":"10.1210\/jc.2015-1036","article-title":"Seven novel deleterious LEPR mutations found in early-onset obesity: a \u0394Exon6-8 shared by subjects from Reunion Island, France, suggests a founder effect","volume":"100","author":"Huvenne","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2025101705020449700_lvaf065-B113","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1002\/oby.21142","article-title":"Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population","volume":"25","author":"Saeed","year":"2017","journal-title":"Obesity (Silver Spring)"},{"issue":"5","key":"2025101705020449700_lvaf065-B114","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/j.jmb.2019.08.016","article-title":"From biology to genes and back again: gene discovery for monogenic forms of beta-cell dysfunction in diabetes","volume":"432","author":"De Franco","year":"2020","journal-title":"J Mol Biol"},{"issue":"5","key":"2025101705020449700_lvaf065-B115","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1056\/NEJMoa061759","article-title":"Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations","volume":"355","author":"Pearson","year":"2006","journal-title":"N Engl J Med"},{"issue":"8","key":"2025101705020449700_lvaf065-B116","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1016\/S2213-8587(18)30106-2","article-title":"Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study","volume":"6","author":"Bowman","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9392","key":"2025101705020449700_lvaf065-B117","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/S0140-6736(03)14571-0","article-title":"Genetic cause of hyperglycaemia and response to treatment in diabetes","volume":"362","author":"Pearson","year":"2003","journal-title":"Lancet"},{"issue":"5","key":"2025101705020449700_lvaf065-B118","doi-asserted-by":"publisher","first-page":"e20191593","DOI":"10.1084\/jem.20191593","article-title":"The pleiotropic roles of leptin in metabolism, immunity, and cancer","volume":"218","author":"de Candia","year":"2021","journal-title":"J Exp Med"},{"issue":"2","key":"2025101705020449700_lvaf065-B119","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jgg.2021.01.008","article-title":"Leptin gene-targeted editing in ob\/ob mouse adipose tissue based on the CRISPR\/Cas9 system","volume":"48","author":"Zhu","year":"2021","journal-title":"J Genet Genomics"},{"issue":"2","key":"2025101705020449700_lvaf065-B120","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s00125-021-05597-y","article-title":"Systematic genetic testing for recessively inherited monogenic diabetes: a cross-sectional study in paediatric diabetes clinics","volume":"65","author":"Patel","year":"2022","journal-title":"Diabetologia"},{"issue":"10","key":"2025101705020449700_lvaf065-B121","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1007\/s00125-016-4056-7","article-title":"South Asian individuals with diabetes who are referred for MODY testing in the UK have a lower mutation pick-up rate than white European people","volume":"59","author":"Misra","year":"2016","journal-title":"Diabetologia"},{"issue":"1","key":"2025101705020449700_lvaf065-B122","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/s41467-017-00895-9","article-title":"Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance","volume":"8","author":"Patel","year":"2017","journal-title":"Nat Commun"},{"issue":"3","key":"2025101705020449700_lvaf065-B123","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S2213-8587(13)70059-7","article-title":"Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study","volume":"1","author":"Busiah","year":"2013","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"2025101705020449700_lvaf065-B124","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2337\/dc20-1520","article-title":"Long-term follow-up of glycemic and neurological outcomes in an international series of patients with sulfonylurea-treated ABCC8 permanent neonatal diabetes","volume":"44","author":"Bowman","year":"2021","journal-title":"Diabetes Care"},{"issue":"2","key":"2025101705020449700_lvaf065-B125","doi-asserted-by":"publisher","first-page":"215","DOI":"10.2337\/dc18-1060","article-title":"Cognitive, neurological, and behavioral features in adults with KCNJ11 neonatal diabetes","volume":"42","author":"Bowman","year":"2019","journal-title":"Diabetes Care"},{"issue":"7","key":"2025101705020449700_lvaf065-B126","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s11892-018-1016-2","article-title":"Congenital diabetes: comprehensive genetic testing allows for improved diagnosis and treatment of diabetes and other associated features","volume":"18","author":"Letourneau","year":"2018","journal-title":"Curr Diab Rep"},{"issue":"11","key":"2025101705020449700_lvaf065-B127","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1016\/j.ajhg.2022.09.014","article-title":"Reduced penetrance of MODY-associated HNF1A\/HNF4A variants but not GCK variants in clinically unselected cohorts","volume":"109","author":"Mirshahi","year":"2022","journal-title":"Am J Hum Genet"},{"issue":"12","key":"2025101705020449700_lvaf065-B128","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.2337\/diacare.25.12.2287","article-title":"Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriers","volume":"25","author":"Stride","year":"2002","journal-title":"Diabetes Care"},{"key":"2025101705020449700_lvaf065-B129","doi-asserted-by":"publisher","first-page":"403","DOI":"10.2147\/DMSO.S141235","article-title":"Reasons for discontinuation of GLP1 receptor agonists: data from a real-world cross-sectional survey of physicians and their patients with type 2 diabetes","volume":"10","author":"Sikirica","year":"2017","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"10402","key":"2025101705020449700_lvaf065-B130","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/S0140-6736(23)01200-X","article-title":"Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial","volume":"402","author":"Garvey","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"2025101705020449700_lvaf065-B131","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1146\/annurev-med-043021-014919","article-title":"New frontiers in obesity treatment: GLP-1 and nascent nutrient-stimulated hormone-based therapeutics","volume":"74","author":"Jastreboff","year":"2023","journal-title":"Annu Rev Med"},{"issue":"11","key":"2025101705020449700_lvaf065-B132","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.2337\/db21-0459","article-title":"GIP receptor agonism attenuates GLP-1 receptor agonist-induced nausea and emesis in preclinical models","volume":"70","author":"Borner","year":"2021","journal-title":"Diabetes"},{"issue":"6","key":"2025101705020449700_lvaf065-B133","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.tem.2020.02.006","article-title":"How may GIP enhance the therapeutic efficacy of GLP-1?","volume":"31","author":"Samms","year":"2020","journal-title":"Trends Endocrinol Metab"},{"issue":"7","key":"2025101705020449700_lvaf065-B134","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/nm727","article-title":"Inhibition of gastric inhibitory polypeptide signaling prevents obesity","volume":"8","author":"Miyawaki","year":"2002","journal-title":"Nat Med"},{"key":"2025101705020449700_lvaf065-B135","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.molmet.2018.09.009","article-title":"LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: from discovery to clinical proof of concept","volume":"18","author":"Coskun","year":"2018","journal-title":"Mol Metab"},{"issue":"6","key":"2025101705020449700_lvaf065-B136","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.2337\/dc19-1892","article-title":"Effects of novel dual GIP and GLP-1 receptor agonist tirzepatide on biomarkers of nonalcoholic steatohepatitis in patients with type 2 diabetes","volume":"43","author":"Hartman","year":"2020","journal-title":"Diabetes Care"},{"issue":"11","key":"2025101705020449700_lvaf065-B137","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.2337\/dci22-0034","article-title":"Management of hyperglycemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)","volume":"45","author":"Davies","year":"2022","journal-title":"Diabetes Care"},{"issue":"10","key":"2025101705020449700_lvaf065-B138","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1056\/NEJMoa2410819","article-title":"Tirzepatide for obesity treatment and diabetes prevention","volume":"392","author":"Jastreboff","year":"2025","journal-title":"N Engl J Med"},{"issue":"1","key":"2025101705020449700_lvaf065-B139","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrneph.2016.170","article-title":"Renal, metabolic and cardiovascular considerations of SGLT2 inhibition","volume":"13","author":"DeFronzo","year":"2017","journal-title":"Nat Rev Nephrol"},{"issue":"13","key":"2025101705020449700_lvaf065-B140","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.3390\/foods12132480","article-title":"Shotgun metagenomic sequencing revealed the prebiotic potential of a fruit juice drink with fermentable fibres in healthy humans","volume":"12","author":"Bester","year":"2023","journal-title":"Foods"},{"issue":"2","key":"2025101705020449700_lvaf065-B141","doi-asserted-by":"publisher","first-page":"234","DOI":"10.4183\/aeb.2023.234","article-title":"Obesity and gut-brain axis","volume":"19","author":"Micic","year":"2023","journal-title":"Acta Endocrinol (Buchar)"},{"issue":"3","key":"2025101705020449700_lvaf065-B142","doi-asserted-by":"publisher","first-page":"128","DOI":"10.7869\/tg.684","article-title":"Insight into gut microbiota of obese and lean individuals: a metagenomic study in Indian population using next-generation sequencing approach","volume":"43","author":"Bahadur","year":"2022","journal-title":"Trop Gastroenterol."},{"issue":"1","key":"2025101705020449700_lvaf065-B143","doi-asserted-by":"publisher","first-page":"100391","DOI":"10.1016\/j.crmeth.2022.100391","article-title":"Comprehensive evaluation of shotgun metagenomics, amplicon sequencing, and harmonization of these platforms for epidemiological studies","volume":"3","author":"Usyk","year":"2023","journal-title":"Cell Rep Methods"},{"issue":"1","key":"2025101705020449700_lvaf065-B144","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1038\/s41598-021-82726-y","article-title":"Comparison between 16S rRNA and shotgun sequencing data for the taxonomic characterization of the gut microbiota","volume":"11","author":"Durazzi","year":"2021","journal-title":"Sci Rep"},{"issue":"1","key":"2025101705020449700_lvaf065-B145","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jfutfo.2021.08.001","article-title":"The challenges of future foods from prevention of nutrient deficiencies to the management of diabetes","volume":"1","author":"Hamrick","year":"2021","journal-title":"Future Foods"},{"issue":"24","key":"2025101705020449700_lvaf065-B146","doi-asserted-by":"publisher","first-page":"5096","DOI":"10.3390\/nu15245096","article-title":"Nutritional strategies for the management of type 2 diabetes mellitus: a narrative review","volume":"15","author":"Minari","year":"2023","journal-title":"Nutrients"},{"issue":"5","key":"2025101705020449700_lvaf065-B147","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.cell.2015.11.001","article-title":"Personalized nutrition by prediction of glycemic responses","volume":"163","author":"Zeevi","year":"2015","journal-title":"Cell"},{"issue":"1","key":"2025101705020449700_lvaf065-B148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41367-020-0014-4","article-title":"Nutrigenetics-personalized nutrition in obesity and cardiovascular diseases","volume":"10","author":"Barrea","year":"2020","journal-title":"Int J Obes Suppl"},{"key":"2025101705020449700_lvaf065-B149","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/B978-0-12-824412-8.00019-9","volume-title":"Role of Nutrigenomics in Modern-day Healthcare and Drug Discovery","author":"Odoh","year":"2023"},{"issue":"5","key":"2025101705020449700_lvaf065-B150","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3390\/nu16050581","article-title":"Precision nutrition unveiled: gene-nutrient interactions, microbiota dynamics, and lifestyle factors in obesity management","volume":"16","author":"Mansour","year":"2024","journal-title":"Nutrients"},{"issue":"8003","key":"2025101705020449700_lvaf065-B151","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41586-024-07019-6","article-title":"Genetic drivers of heterogeneity in type 2 diabetes pathophysiology","volume":"627","author":"Suzuki","year":"2024","journal-title":"Nature"},{"issue":"12","key":"2025101705020449700_lvaf065-B152","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/s10038-023-01189-3","article-title":"Deciphering the genetic landscape of obesity: a data-driven approach to identifying plausible causal genes and therapeutic targets","volume":"68","author":"Ang","year":"2023","journal-title":"J Hum Genet"},{"issue":"5","key":"2025101705020449700_lvaf065-B153","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/S2213-8587(18)30037-8","article-title":"Precision nutrition for prevention and management of type 2 diabetes","volume":"6","author":"Wang","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"2025101705020449700_lvaf065-B154","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s13668-024-00550-y","article-title":"The future of obesity management through precision nutrition: putting the individual at the center","volume":"13","author":"Ulusoy-Gezer","year":"2024","journal-title":"Curr Nutr Rep"},{"issue":"10","key":"2025101705020449700_lvaf065-B155","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S2213-8587(22)00218-2","article-title":"Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study","volume":"10","author":"Gregory","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10146","key":"2025101705020449700_lvaf065-B156","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0140-6736(18)31506-X","article-title":"Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study","volume":"392","author":"Rawshani","year":"2018","journal-title":"Lancet"},{"key":"2025101705020449700_lvaf065-B157","volume-title":"Diabetes","author":"World Health Organization","year":"2023"},{"issue":"9","key":"2025101705020449700_lvaf065-B158","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1089\/dia.2021.0110","article-title":"A worldwide perspective on COVID-19 and diabetes management in 22,820 children from the SWEET project: diabetic ketoacidosis rates increase and glycemic control is maintained","volume":"23","author":"Danne","year":"2021","journal-title":"Diabetes Technol Ther"},{"key":"2025101705020449700_lvaf065-B159","volume-title":"White Paper: Modeling the Total Economic Value of Novel Type 1 Diabetes (T1D) Therapeutic Concepts","author":"Ward","year":"2020"},{"issue":"11","key":"2025101705020449700_lvaf065-B160","doi-asserted-by":"publisher","first-page":"14620","DOI":"10.1111\/dme.14620","article-title":"Widening health inequalities related to type 1 diabetes care in children and young people in the UK: a time to act now","volume":"38","author":"Ng","year":"2021","journal-title":"Diabet Med"},{"issue":"9","key":"2025101705020449700_lvaf065-B161","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/pdi.2061","article-title":"Influences of social issues on type 1 diabetes self-management: are we doing enough?","volume":"33","author":"Akhter","year":"2016","journal-title":"Pract Diab"},{"issue":"1","key":"2025101705020449700_lvaf065-B162","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2337\/cd16-0020","article-title":"Stigma in people with type 1 or type 2 diabetes","volume":"35","author":"Liu","year":"2017","journal-title":"Clin Diabetes"},{"issue":"Supplement_1","key":"2025101705020449700_lvaf065-B163","doi-asserted-by":"publisher","first-page":"S126","DOI":"10.2337\/dc24-S007","article-title":"7. Diabetes technology: standards of care in diabetes-2024","volume":"47","author":"American Diabetes Association Professional Practice Committee","year":"2024","journal-title":"Diabetes Care"},{"issue":"8","key":"2025101705020449700_lvaf065-B164","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1111\/pedi.13451","article-title":"ISPAD clinical practice consensus guidelines 2022: diabetes technologies: glucose monitoring","volume":"23","author":"Tauschmann","year":"2022","journal-title":"Pediatr Diabetes"},{"issue":"3","key":"2025101705020449700_lvaf065-B165","doi-asserted-by":"publisher","first-page":"526","DOI":"10.2337\/dc22-1297","article-title":"CGM metrics identify dysglycemic states in participants from the TrialNet pathway to prevention study","volume":"46","author":"Wilson","year":"2023","journal-title":"Diabetes Care"},{"issue":"2","key":"2025101705020449700_lvaf065-B166","doi-asserted-by":"publisher","first-page":"365","DOI":"10.2337\/dc21-0602","article-title":"CGM metrics predict imminent progression to type 1 diabetes: autoimmunity screening for kids (ASK) study","volume":"45","author":"Steck","year":"2022","journal-title":"Diabetes Care"},{"issue":"22","key":"2025101705020449700_lvaf065-B167","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1056\/NEJMra2215899","article-title":"Digital technology for diabetes","volume":"389","author":"Hughes","year":"2023","journal-title":"N Engl J Med"},{"issue":"10270","key":"2025101705020449700_lvaf065-B168","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S0140-6736(20)32514-9","article-title":"A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial","volume":"397","author":"Bergenstal","year":"2021","journal-title":"Lancet"},{"issue":"17","key":"2025101705020449700_lvaf065-B169","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1056\/NEJMoa2303911","article-title":"Automated insulin delivery in women with pregnancy complicated by type 1 diabetes","volume":"389","author":"Lee","year":"2023","journal-title":"N Engl J Med"},{"issue":"3","key":"2025101705020449700_lvaf065-B170","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1056\/NEJMoa2111673","article-title":"Randomized trial of closed-loop control in very young children with type 1 diabetes","volume":"386","author":"Ware","year":"2022","journal-title":"N Engl J Med"},{"issue":"12","key":"2025101705020449700_lvaf065-B171","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1001\/jama.2023.2063","article-title":"Effect of tight glycemic control on pancreatic beta cell function in newly diagnosed pediatric type 1 diabetes: a randomized clinical trial","volume":"329","author":"McVean","year":"2023","journal-title":"JAMA"},{"issue":"11","key":"2025101705020449700_lvaf065-B172","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1056\/NEJMoa2210834","article-title":"Trial of hybrid closed-loop control in young children with type 1 diabetes","volume":"388","author":"Wadwa","year":"2023","journal-title":"N Engl J Med"},{"issue":"13","key":"2025101705020449700_lvaf065-B173","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1056\/NEJMoa2205225","article-title":"Multicenter, randomized trial of a bionic pancreas in type 1 diabetes","volume":"387","author":"Bionic Pancreas Research Group","year":"2022","journal-title":"N Engl J Med"},{"key":"2025101705020449700_lvaf065-B174","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1109\/RBME.2023.3331297","article-title":"Artificial intelligence and machine learning for improving glycemic control in diabetes: best practices, pitfalls, and opportunities","volume":"17","author":"Jacobs","year":"2024","journal-title":"IEEE Rev Biomed Eng"},{"issue":"9","key":"2025101705020449700_lvaf065-B175","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1038\/s41591-020-1045-7","article-title":"Insulin dose optimization using an automated artificial intelligence-based decision support system in youths with type 1 diabetes","volume":"26","author":"Nimri","year":"2020","journal-title":"Nat Med"},{"issue":"3","key":"2025101705020449700_lvaf065-B176","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1159\/000531766","article-title":"International guidelines for the diagnosis and management of hyperinsulinism","volume":"97","author":"De Leon","year":"2024","journal-title":"Horm Res Paediatr"},{"issue":"1","key":"2025101705020449700_lvaf065-B177","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jpedsurg.2018.10.030","article-title":"Surgical treatment of congenital hyperinsulinism: results from 500 pancreatectomies in neonates and children","volume":"54","author":"Adzick","year":"2019","journal-title":"J Pediatr Surg"},{"issue":"2","key":"2025101705020449700_lvaf065-B178","doi-asserted-by":"publisher","first-page":"198","DOI":"10.2337\/dc11-1296","article-title":"Glucose metabolism in 105 children and adolescents after pancreatectomy for congenital hyperinsulinism","volume":"35","author":"Beltrand","year":"2012","journal-title":"Diabetes Care"},{"issue":"1","key":"2025101705020449700_lvaf065-B179","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2337\/diabetes.55.01.06.db05-1128","article-title":"Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography","volume":"55","author":"Otonkoski","year":"2006","journal-title":"Diabetes"},{"issue":"1","key":"2025101705020449700_lvaf065-B180","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13023-022-02214-y","article-title":"Congenital hyperinsulinism in infancy and childhood: challenges, unmet needs and the perspective of patients and families","volume":"17","author":"Banerjee","year":"2022","journal-title":"Orphanet J Rare Dis"},{"key":"2025101705020449700_lvaf065-B181","doi-asserted-by":"publisher","first-page":"1071206","DOI":"10.3389\/fped.2023.1071206","article-title":"New approaches to screening and management of neonatal hypoglycemia based on improved understanding of the molecular mechanism of hypoglycemia","volume":"11","author":"Stanley","year":"2023","journal-title":"Front Pediatr"},{"key":"2025101705020449700_lvaf065-B182","doi-asserted-by":"publisher","first-page":"1179102","DOI":"10.3389\/fendo.2023.1179102","article-title":"Neonatal hypoglycemia: lack of evidence for a safe management","volume":"14","author":"Roeper","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2025101705020449700_lvaf065-B183","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1210\/clinem\/dgab601","article-title":"Continuous glucose monitoring in the management of neonates with persistent hypoglycemia and congenital hyperinsulinism","volume":"107","author":"Win","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"2025101705020449700_lvaf065-B184","doi-asserted-by":"publisher","first-page":"20552076231192011","DOI":"10.1177\/20552076231192011","article-title":"The behaviour change behind a successful pilot of hypoglycaemia reduction with HYPO-CHEAT","volume":"9","author":"Worth","year":"2023","journal-title":"Digit Health"},{"issue":"4","key":"2025101705020449700_lvaf065-B185","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s00247-021-05206-5","article-title":"Congenital hyperinsulinism: localization of a focal lesion with 18F-FDOPA positron emission tomography","volume":"52","author":"States","year":"2022","journal-title":"Pediatr Radiol"},{"issue":"4","key":"2025101705020449700_lvaf065-B186","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/ajmg.c.31737","article-title":"Congenital hyperinsulinism disorders: genetic and clinical characteristics","volume":"181","author":"Rosenfeld","year":"2019","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"2025101705020449700_lvaf065-B187","doi-asserted-by":"publisher","first-page":"873254","DOI":"10.3389\/fendo.2022.873254","article-title":"Congenital hyperinsulinism: current laboratory-based approaches to the genetic diagnosis of a heterogeneous disease","volume":"13","author":"Hewat","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"11","key":"2025101705020449700_lvaf065-B188","doi-asserted-by":"publisher","first-page":"4133","DOI":"10.1210\/jc.2015-2539","article-title":"High risk of diabetes and neurobehavioral deficits in individuals with surgically treated hyperinsulinism","volume":"100","author":"Lord","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2025101705020449700_lvaf065-B189","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fendo.2013.00060","article-title":"Abnormal neurodevelopmental outcomes are common in children with transient congenital hyperinsulinism","volume":"4","author":"Avatapalle","year":"2013","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/193\/Supplement_2\/ii47\/64633668\/lvaf065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/193\/Supplement_2\/ii47\/64633668\/lvaf065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T09:02:09Z","timestamp":1760691729000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/193\/Supplement_2\/ii47\/8281957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":189,"journal-issue":{"issue":"Supplement_2","published-print":{"date-parts":[[2025,10,17]]}},"URL":"https:\/\/doi.org\/10.1093\/ejendo\/lvaf065","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,10]]}}}