{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T01:43:52Z","timestamp":1764985432494,"version":"3.46.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["www.embopress.org"],"crossmark-restriction":false},"short-container-title":["EMBO Reports"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>\n                    The macrophage infectivity potentiator protein from\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    (TcMIP) is a major virulence factor secreted by the etiological agent of Chagas' disease. It is functionally involved in host cell invasion. We have determined the three\u2010dimensional crystal structure of TcMIP at 1.7 \u00c5 resolution. The monomeric protein displays a peptidyl\u2010prolyl\n                    <jats:italic>cis\u2013trans<\/jats:italic>\n                    isomerase (PPIase) core, encompassing the characteristic rotamase hydrophobic active site, thus explaining the strong inhibition of TcMIP by the immunosuppressant FK506 and related drugs. In TcMIP, the twisted \u03b2\u2010sheet of the core is extended by an extra \u03b2\u2010strand, preceded by a long, exposed N\u2010terminal \u03b1\u2010helix, which might be a target recognition element. An invasion assay shows that the MIP protein from\n                    <jats:italic>Legionella pneumophila<\/jats:italic>\n                    (LpMIP), which has an equivalent N\u2010terminal \u03b1\u2010helix, can substitute for TcMIP. An additional exposed \u03b1\u2010helix, this one unique to TcMIP, is located in the C\u2010terminus of the protein. The high\u2010resolution structure reported here opens the possibility for the design of new inhibitory drugs that might be useful for the clinical treatment of American trypanosomiasis.\n                  <\/jats:p>","DOI":"10.1093\/embo-reports\/kvf009","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:28:32Z","timestamp":1027708112000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["<i>Trypanosoma cruzi<\/i>\n                    macrophage infectivity potentiator has a rotamase core and a highly exposed \u03b1\u2010helix"],"prefix":"10.1038","volume":"3","author":[{"given":"Pedro Jos\u00e9 Barbosa","family":"Pereira","sequence":"first","affiliation":[{"name":"Institut de Biolog\u00eda Molecular\u2010CSIC  Jordi Girona 18\u201026 E\u201008034 Barcelona Spain"}]},{"given":"M Cristina","family":"Vega","sequence":"additional","affiliation":[{"name":"Institut de Biolog\u00eda Molecular\u2010CSIC  Jordi Girona 18\u201026 E\u201008034 Barcelona Spain"}]},{"given":"Elena","family":"Gonz\u00e1lez\u2010Rey","sequence":"additional","affiliation":[{"name":"Instituto de Parasitolog\u00eda y Biomedicina\u2010CSIC  Ventanilla 11 E\u201018001 Granada Spain"}]},{"given":"Rafael","family":"Fern\u00e1ndez\u2010Carazo","sequence":"additional","affiliation":[{"name":"Instituto de Parasitolog\u00eda y Biomedicina\u2010CSIC  Ventanilla 11 E\u201018001 Granada Spain"}]},{"given":"Sandra","family":"Macedo\u2010Ribeiro","sequence":"additional","affiliation":[{"name":"Present address: Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve  8000 Faro Portugal"}]},{"given":"F Xavier","family":"Gomis\u2010R\u00fcth","sequence":"additional","affiliation":[{"name":"Institut de Biolog\u00eda Molecular\u2010CSIC  Jordi Girona 18\u201026 E\u201008034 Barcelona Spain"}]},{"given":"Antonio","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Instituto de Parasitolog\u00eda y Biomedicina\u2010CSIC  Ventanilla 11 E\u201018001 Granada Spain"}]},{"given":"Miquel","family":"Coll","sequence":"additional","affiliation":[{"name":"Institut de Biolog\u00eda Molecular\u2010CSIC  Jordi Girona 18\u201026 E\u201008034 Barcelona Spain"}]}],"member":"297","published-online":{"date-parts":[[2002,1]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/6.1.37"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444998003254"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3411"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(98)80066-0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90124-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5272.239"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444994003112"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)91033-9"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi960975p"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444999016571"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.24.13093"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(94)00123-5"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1128\/iai.57.4.1263-1270.1989","article-title":"DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity","volume":"57","author":"Engleberg N.C.","year":"1989","journal-title":"Infect. 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