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Each behaviour is mainly considered in isolation, despite clear behavioural and biological interdependencies. The aim of this study was to investigate associations of five-part movement compositions with adiposity and cardiometabolic biomarkers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cross-sectional data from six studies (n = 15 253 participants; five countries) from the Prospective Physical Activity, Sitting and Sleep consortium were analysed. Device-measured time spent in sleep, SB, standing, light-intensity physical activity (LIPA), and moderate-vigorous physical activity (MVPA) made up the composition. Outcomes included body mass index (BMI), waist circumference, HDL cholesterol, total:HDL cholesterol ratio, triglycerides, and glycated haemoglobin (HbA1c). Compositional linear regression examined associations between compositions and outcomes, including modelling time reallocation between behaviours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The average daily composition of the sample (age: 53.7 \u00b1 9.7 years; 54.7% female) was 7.7\u2005h sleeping, 10.4\u2005h sedentary, 3.1\u2005h standing, 1.5\u2005h LIPA, and 1.3\u2005h MVPA. A greater MVPA proportion and smaller SB proportion were associated with better outcomes. Reallocating time from SB, standing, LIPA, or sleep into MVPA resulted in better scores across all outcomes. For example, replacing 30\u2005min of SB, sleep, standing, or LIPA with MVPA was associated with \u22120.63 (95% confidence interval \u22120.48, \u22120.79), \u22120.43 (\u22120.25, \u22120.59), \u22120.40 (\u22120.25, \u22120.56), and \u22120.15 (0.05, \u22120.34) kg\/m2 lower BMI, respectively. Greater relative standing time was beneficial, whereas sleep had a detrimental association when replacing LIPA\/MVPA and positive association when replacing SB. The minimal displacement of any behaviour into MVPA for improved cardiometabolic health ranged from 3.8 (HbA1c) to 12.7 (triglycerides) min\/day.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Compositional data analyses revealed a distinct hierarchy of behaviours. Moderate-vigorous physical activity demonstrated the strongest, most time-efficient protective associations with cardiometabolic outcomes. Theoretical benefits from reallocating SB into sleep, standing, or LIPA required substantial changes in daily activity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehad717","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T17:23:51Z","timestamp":1699723431000},"page":"458-471","source":"Crossref","is-referenced-by-count":107,"title":["Device-measured physical activity and cardiometabolic health: the Prospective Physical Activity, Sitting, and Sleep (ProPASS) consortium"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7684-3571","authenticated-orcid":false,"given":"Joanna M","family":"Blodgett","sequence":"first","affiliation":[{"name":"Institute of Sport Exercise and Health, Division of Surgery and Interventional Sciences, University College London , London , UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3115-338X","authenticated-orcid":false,"given":"Matthew N","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Mackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney , Sydney, NSW , Australia"},{"name":"School of Health Sciences, Faculty of Medicine and Health , University of Sydney, Sydney, NSW , Australia"}]},{"given":"Andrew J","family":"Atkin","sequence":"additional","affiliation":[{"name":"School of Health Sciences and Norwich Epidemiology Centre, University of East Anglia , Norwich , UK"}]},{"given":"Sebastien","family":"Chastin","sequence":"additional","affiliation":[{"name":"School of Health and Life Science Glasgow Caledonian University , Glasgow , UK"},{"name":"Department of Movement and Sport Sciences, Ghent University , Ghent , Belgium"}]},{"given":"Hsiu-Wen","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Public Health, The University of Queensland , Brisbane, Queensland , Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-8069","authenticated-orcid":false,"given":"Kristin","family":"Suorsa","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Turku and Turku University Hospital , Turku , Finland"},{"name":"Centre for Population Health Research, University of Turku and Turku University Hospital , Turku , Finland"}]},{"given":"Esmee A","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada , Granada , Spain"},{"name":"Department of Medical BioSciences, Exercise Physiology ResearchGroup, Radboud University Medical Center , Nijmegen , The Netherlands"}]},{"given":"Pasan","family":"Hettiarcachchi","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University , Sweden"}]},{"given":"Peter J","family":"Johansson","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University , Sweden"},{"name":"Occupational and Environmental Medicine, Uppsala University Hospital , Uppsala , Sweden"}]},{"given":"Lauren B","family":"Sherar","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Health Sciences, Loughborough University , UK"}]},{"given":"Vegar","family":"Rangul","sequence":"additional","affiliation":[{"name":"HUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU) , Norway"}]},{"given":"Richard M","family":"Pulsford","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences, University of Exeter , UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9610-5904","authenticated-orcid":false,"given":"Gita","family":"Mishra","sequence":"additional","affiliation":[{"name":"School of Public Health, The University of Queensland , Brisbane, Queensland , Australia"}]},{"given":"Thijs M H","family":"Eijsvogels","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences, Exercise Physiology ResearchGroup, Radboud University Medical Center , Nijmegen , The Netherlands"}]},{"given":"Sari","family":"Stenholm","sequence":"additional","affiliation":[{"name":"School of Public Health, The University of Queensland , Brisbane, Queensland , Australia"},{"name":"Department of Public Health, University of Turku and Turku University Hospital , Turku , Finland"},{"name":"Research Services, Turku University Hospital and University of Turku , Finland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5432-5271","authenticated-orcid":false,"given":"Alun 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