{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:35:31Z","timestamp":1772159731151,"version":"3.50.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beatriz Galindo"},{"DOI":"10.13039\/501100023561","name":"Ministry of Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023561","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009042","name":"University of Seville","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002385","name":"Ministry of Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"MOHE","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Professorial Council"},{"DOI":"10.13039\/501100014097","name":"MPN","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004625","name":"Universiti Teknologi MARA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014413","name":"UiTM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021701","name":"NIHR Applied Research Collaboration Northwest London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"Imperial NIHR Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Overweight and obesity are modifiable risk factors for atherosclerotic cardiovascular disease (ASCVD) in the general population, but their prevalence in individuals with heterozygous familial hypercholesterolaemia (HeFH) and whether they confer additional risk of ASCVD independent of LDL cholesterol (LDL-C) remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cross-sectional analysis was conducted in 35 540 patients with HeFH across 50 countries, in the EAS FH Studies Collaboration registry. Prevalence of World Health Organization\u2013defined body mass index categories was investigated in adults (n = 29 265) and children\/adolescents (n = 6275); and their association with prevalent ASCVD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Globally, 52% of adults and 27% of children with HeFH were overweight or obese, with the highest prevalence noted in Northern Africa\/Western Asia. A higher overweight\/obesity prevalence was found in non-high-income vs. high-income countries. Median age at familial hypercholesterolaemia diagnosis in adults with obesity was 9 years older than in normal weight adults. Obesity was associated with a more atherogenic lipid profile independent of lipid-lowering medication. Prevalence of coronary artery disease increased progressively across body mass index categories in both children and adults. Compared with normal weight, obesity was associated with higher odds of coronary artery disease in children (odds ratio 9.28, 95% confidence interval 1.77\u201348.77, adjusted for age, sex, lipids, and lipid-lowering medication) and coronary artery disease and stroke in adults (odds ratio 2.35, 95% confidence interval 2.10\u20132.63 and odds ratio 1.65, 95% confidence interval 1.27\u20132.14, respectively), but less consistently with peripheral artery disease. Adjusting for diabetes, hypertension and smoking modestly attenuated the associations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overweight and obesity are common in patients with HeFH and contribute to ASCVD risk from childhood, independent of LDL-C and lipid-lowering medication. Sustained body weight management is needed to reduce the risk of ASCVD in HeFH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehae791","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T08:01:28Z","timestamp":1736755288000},"page":"1127-1140","source":"Crossref","is-referenced-by-count":12,"title":["Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry"],"prefix":"10.1093","volume":"46","author":[{"given":"Amany","family":"Elshorbagy","sequence":"first","affiliation":[{"name":"Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London , White City Campus, 90 Wood Lane, London W12 0BZ ,","place":["UK"]},{"name":"Department of Physiology, Faculty of Medicine, University of Alexandria , Mowassat Campus, Alexandria ,","place":["Egypt"]}]},{"given":"Antonio J","family":"Vallejo-Vaz","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London , White City Campus, 90 Wood Lane, London W12 0BZ ,","place":["UK"]},{"name":"Clinical Epidemiology and Vascular Risk, Instituto de Biomedicina de Sevilla, IBiS\/Hospital Universitario Virgen del Roc\u00edo\/Universidad de Sevilla\/CSIC , Seville ,","place":["Spain"]},{"name":"Faculty of Medicine, Department of Medicine, University of Seville , Seville ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER) de Epidemiolog\u00eda y Salud P\u00fablica, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}]},{"given":"Fotios","family":"Barkas","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London , White City Campus, 90 Wood Lane, London W12 0BZ ,","place":["UK"]},{"name":"Faculty of Medicine, Department of Internal Medicine, School of Health Sciences, University of Ioannina , Ioannina ,","place":["Greece"]}]},{"given":"Alexander R M","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London , White City Campus, 90 Wood Lane, London W12 0BZ ,","place":["UK"]}]},{"given":"Christophe A T","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London , White City Campus, 90 Wood Lane, London W12 0BZ ,","place":["UK"]}]},{"given":"Kanika I","family":"Dharmayat","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Public Health, Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London , White City Campus, 90 Wood Lane, London W12 0BZ ,","place":["UK"]}]},{"given":"Alberico L","family":"Catapano","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences, University of Milan , Milan ,","place":["Italy"]},{"name":"Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) MultiMedica , Milan ,","place":["Italy"]}]},{"given":"Tomas","family":"Freiberger","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Surgery and Transplantation, and Medical Faculty, Masaryk University , Brno ,","place":["Czech Republic"]},{"name":"CarDia\u2014National Institute for Metabolic and Cardiovascular Disease Research ,","place":["Czech Republic"]}]},{"given":"G Kees","family":"Hovingh","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam , Amsterdam ,","place":["The Netherlands"]},{"name":"Novo Nordisk , Soborg ,","place":["Denmark"]}]},{"given":"Pedro","family":"Mata","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Hipercolesterolemia Familiar , Madrid ,","place":["Spain"]}]},{"given":"Frederick J","family":"Raal","sequence":"additional","affiliation":[{"name":"Carbohydrate and Lipid Metabolism Research Unit, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg ,","place":["South Africa"]}]},{"given":"Raul D","family":"Santos","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), University of S\u00e3o Paulo and Hospital Israelita Albert Einstein , S\u00e3o Paulo ,","place":["Brazil"]}]},{"given":"Handrean","family":"Soran","sequence":"additional","affiliation":[{"name":"Manchester University NHS Foundation Trust , Manchester ,","place":["UK"]}]},{"given":"Gerald F","family":"Watts","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, School of Medicine, University of Western Australia , Perth, WA ,","place":["Australia"]},{"name":"Department of Cardiology, Lipid Disorders Clinic, Cardiometabolic Services, Royal Perth Hospital , Perth, WA ,","place":["Australia"]}]},{"given":"Marianne","family":"Abifadel","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Laboratory of Biochemistry and Molecular Therapeutics, Saint Joseph University , Beirut ,","place":["Lebanon"]}]},{"given":"Carlos A","family":"Aguilar-Salinas","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n de Enfermedades Metab\u00f3licas, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n , Mexico City ,","place":["M\u00e9xico"]},{"name":"Tecnol\u00f3gico de Monterrey, Escuela de Medicina y Ciencias de la Salud , Monterrey ,","place":["Mexico"]}]},{"given":"Khalid F","family":"Alhabib","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences, King Fahad Cardiac Centre, College of Medicine, King Saud University Medical City, King Saud University , Riyadh ,","place":["Saudi Arabia"]}]},{"given":"Mutaz","family":"Alkhnifsawi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Al Qadisiyah , Al Diwaniyah ,","place":["Iraq"]},{"name":"College of Medicine, University of Warith Al-Anbiyaa , Karbala ,","place":["Iraq"]}]},{"given":"Wael","family":"Almahmeed","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, Heart and Vascular Institute , Abu Dhabi ,","place":["United Arab Emirates"]}]},{"given":"Fahad","family":"Alnouri","sequence":"additional","affiliation":[{"name":"Cardiovascular Prevention Unit, Adult Cardiology Department, Prince Sultan Cardiac Centre , Riyadh ,","place":["Saudi Arabia"]}]},{"given":"Rodrigo","family":"Alonso","sequence":"additional","affiliation":[{"name":"Centre for Advanced Metabolic Medicine and Nutrition , Santiago ,","place":["Chile"]}]},{"given":"Khalid","family":"Al-Rasadi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine and Health Science and Medical Research Centre, Sultan Qaboos University , Muscat ,","place":["Oman"]}]},{"given":"Ahmad","family":"Al-Sarraf","sequence":"additional","affiliation":[{"name":"Sabah Al Ahmad Cardiac Centre , Kuwait City ,","place":["Kuwait"]}]},{"given":"Marcello","family":"Arca","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome , Rome ,","place":["Italy"]}]},{"given":"Tester F","family":"Ashavaid","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, PD Hinduja Hospital and Medical Research Centre Mahim , Mumbai ,","place":["India"]}]},{"given":"Maurizio","family":"Averna","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Maternal and Infantile Care, Internal Medicine and Medical Specialties, University of Palermo , Palermo ,","place":["Italy"]},{"name":"Istituto di Biofisica, Consiglio Nazionale delle Ricerche , Palermo ,","place":["Italy"]}]},{"given":"Maciej","family":"Banach","sequence":"additional","affiliation":[{"name":"Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL) , Lodz ,","place":["Poland"]},{"name":"Department of Cardiology and Congenital Diseases of Adults, Polish Mother\u2019s Memorial Hospital Research Institute (PMMHRI) , Lodz ,","place":["Poland"]},{"name":"Cardiovascular Research Centre, University of Zielona Gora , Zielona Gora ,","place":["Poland"]}]},{"given":"Marianne","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Diabetology, Centre hospitalier de Luxembourg , Luxembourg City ,","place":["Luxembourg"]}]},{"given":"Christoph J","family":"Binder","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Medical University of Vienna , Vienna ,","place":["Austria"]}]},{"given":"Mafalda","family":"Bourbon","sequence":"additional","affiliation":[{"name":"Unidade de Investiga\u00e7\u00e3o e Desenvolvimento, Grupo de Investiga\u00e7\u00e3o Cardiovascular, Departamento de Promo\u00e7\u00e3o da Sa\u00fade e Preven\u00e7\u00e3o de Doen\u00e7as N\u00e3o Transmiss\u00edveis, Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge , Lisbon ,","place":["Portugal"]},{"name":"Faculty of Sciences, Biosystems and Integrative Sciences Institute (BioISI), University of Lisbon , Lisbon ,","place":["Portugal"]}]},{"given":"Liam R","family":"Brunham","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Medical Genetics, Centre for Heart Lung Innovation, The University of British Columbia , Vancouver ,","place":["Canada"]}]},{"given":"Krzysztof","family":"Chlebus","sequence":"additional","affiliation":[{"name":"1st Department of Cardiology Medical University of Gda\u0144sk, National Centre of Familial Hypercholesterolaemia in Gda\u0144sk , Gda\u0144sk ,","place":["Poland"]}]},{"given":"Pablo","family":"Corral","sequence":"additional","affiliation":[{"name":"Pharmacology Department, FASTA University, School of Medicine , Mar del Plata ,","place":["Argentina"]}]},{"given":"Diogo","family":"Cruz","sequence":"additional","affiliation":[{"name":"Portuguese Atherosclerosis Society , Lisbon ,","place":["Portugal"]}]},{"given":"Kairat","family":"Davletov","sequence":"additional","affiliation":[{"name":"Research Health Institute, Al Farabi Kazakh National University , Almaty ,","place":["Kazakhstan"]}]},{"given":"Olivier S","family":"Descamps","sequence":"additional","affiliation":[{"name":"Centres Hospitaliers Universitaires HELORA at La Louvi\u00e8re and University of Mons , Mons ,","place":["Belgium"]}]},{"given":"Bambang","family":"Dwiputra","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Cardiology and Vascular Medicine, Universitas Indonesia\u2014Harapan Kita National Cardiovascular Center , Jakarta ,","place":["Indonesia"]}]},{"given":"Marat","family":"Ezhov","sequence":"additional","affiliation":[{"name":"National Medical Research Centre of Cardiology of Ministry of Health of the Russian Federation , Moscow ,","place":["Russia"]}]},{"given":"Urh","family":"Groselj","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Diabetes and Metabolism, University Medical Centre, University Children\u2019s Hospital Ljubljana , Ljubljana ,","place":["Slovenia"]},{"name":"Faculty of Medicine, University of Ljubljana , Ljubljana ,","place":["Slovenia"]}]},{"given":"Mariko","family":"Harada-Shiba","sequence":"additional","affiliation":[{"name":"Osaka Medical and Pharmaceutical University , Takatsuki ,","place":["Japan"]}]},{"given":"Kirsten B","family":"Holven","sequence":"additional","affiliation":[{"name":"National Advisory Unit on Familial Hypercholesterolemia, Oslo University Hospital , Oslo ,","place":["Norway"]}]},{"given":"Steve E","family":"Humphries","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Genetics, Institute for Cardiovascular Science, University College London , London ,","place":["UK"]}]},{"given":"Meral","family":"Kayikcioglu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ege University Medical School , \u0130zmir ,","place":["Turkey"]}]},{"given":"Weerapan","family":"Khovidhunkit","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital , Bangkok ,","place":["Thailand"]}]},{"given":"Katarina","family":"Lalic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Clinic for Endocrinology, Diabetes and Metabolic Diseases, University of Belgrade , Belgrade ,","place":["Serbia"]}]},{"given":"Gustavs","family":"Latkovskis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Research Institute of Cardiology and Regenerative Medicine, University of Latvia, Pauls Stradins Clinical University Hospital , Riga ,","place":["Latvia"]}]},{"given":"Ulrich","family":"Laufs","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kardiologie, Universit\u00e4tsklinikum Leipzig , Leipzig ,","place":["Germany"]}]},{"given":"Evangelos","family":"Liberopoulos","sequence":"additional","affiliation":[{"name":"First Department of Propaedeutic and Internal Medicine, School of Medicine, National and Kapodistian University of Athens , Athens ,","place":["Greece"]}]},{"given":"Marcos M","family":"Lima-Martinez","sequence":"additional","affiliation":[{"name":"Universidad de Oriente, N\u00facleo Bol\u00edvar , Ciudad Bol\u00edvar ,","place":["Venezuela"]}]},{"given":"Vincent","family":"Maher","sequence":"additional","affiliation":[{"name":"Advanced Lipid Management and Research Centre (ALMAR), Tallaght University Hospital , Dublin ,","place":["Ireland"]}]},{"given":"A David","family":"Marais","sequence":"additional","affiliation":[{"name":"Chemical Pathology, University of Cape Town Health Science Faculty , Cape Town ,","place":["South Africa"]}]},{"given":"Winfried","family":"M\u00e4rz","sequence":"additional","affiliation":[{"name":"DACH Society for the Prevention of Heart and Circulatory Diseases , Hamburg ,","place":["Germany"]},{"name":"Medical Faculty Mannheim, Department of Internal Medicine, Heidelberg University , Mannheim ,","place":["Germany"]},{"name":"Klinisches Institut f\u00fcr Medizinische und Chemische Labordiagnostik, Medizinische Universit\u00e4t Graz , Graz ,","place":["Austria"]},{"name":"Synlab Akademie, Synlab Holding Deutschland , Mannheim and Augsburg ,","place":["Germany"]}]},{"given":"Erkin","family":"Mirrakhimov","sequence":"additional","affiliation":[{"name":"Kyrgyz State Medical Academy , Bishkek ,","place":["Kyrgyzstan"]},{"name":"College of Medicine, Korea University , Seoul ,","place":["Korea"]}]},{"given":"Andr\u00e9 R","family":"Miserez","sequence":"additional","affiliation":[{"name":"Diagene Research Institute and Swiss Society for Familial Forms of Hypercholesterolemia (SSFH) , Reinach ,","place":["Switzerland"]},{"name":"Faculty of Medicine, University of Basel , Basel ,","place":["Switzerland"]}]},{"given":"Olena","family":"Mitchenko","sequence":"additional","affiliation":[{"name":"Department of Dyslipidaemia, Institute of Cardiology, National Academy of Medical Sciences , Kiev ,","place":["Ukraine"]}]},{"given":"Hapizah","family":"Nawawi","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM) and Faculty of Medicine, Universiti Teknologi MARA (UiTM) , Sungai Buloh, Selangor ,","place":["Malaysia"]}]},{"given":"B\u00f8rge G","family":"Nordestgaard","sequence":"additional","affiliation":[{"name":"Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen , Copenhagen ,","place":["Denmark"]}]},{"given":"Andrie G","family":"Panayiotou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, School of Health Sciences, Cyprus University of Technology , Limassol ,","place":["Cyprus"]}]},{"given":"Gy\u00f6rgy","family":"Paragh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Metabolic Diseases, Department of Internal Medicine, University of Debrecen , Debrecen ,","place":["Hungary"]}]},{"given":"Zaneta","family":"Petrulioniene","sequence":"additional","affiliation":[{"name":"Vilnius University Faculty of Medicine and Vilnius University Hospital Santaros Klinikos , Vilnius ,","place":["Lithuania"]}]},{"given":"Belma","family":"Pojskic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cantonal Hospital Zenica, University of Zenica , Zenica ,","place":["Bosnia and Herzegovina"]}]},{"given":"Arman","family":"Postadzhiyan","sequence":"additional","affiliation":[{"name":"Medical University of Sofia , Sofia ,","place":["Bulgaria"]}]},{"given":"Ashraf","family":"Reda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Cardiology, Menoufia University , Al Minufiyah ,","place":["Egypt"]}]},{"given":"\u017deljko","family":"Reiner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Centre Zagreb, and School of Medicine, University of Zagreb , Zagreb ,","place":["Croatia"]}]},{"given":"Ximena","family":"Reyes","sequence":"additional","affiliation":[{"name":"GENYCO Program, Comisi\u00f3n Honoraria para la Salud Cardiovascular , Montevideo ,","place":["Uruguay"]}]},{"given":"Fouzia","family":"Sadiq","sequence":"additional","affiliation":[{"name":"Directorate of Research, Shifa Tameer-e-Millat University , Islamabad ,","place":["Pakistan"]}]},{"given":"Wilson Ehidiamen","family":"Sadoh","sequence":"additional","affiliation":[{"name":"Department of Child Health, University of Benin Teaching Hospital , Benin City ,","place":["Nigeria"]}]},{"given":"Heribert","family":"Schunkert","sequence":"additional","affiliation":[{"name":"Clinic for Heart and Circulatory Diseases, German Heart Centre Munich, Technical University Munich , Munich ,","place":["Germany"]},{"name":"German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance , Munich ,","place":["Germany"]}]},{"given":"Aleksandr B","family":"Shek","sequence":"additional","affiliation":[{"name":"Department of Coronary Heart Disease and Atherosclerosis, Republican Specialized Centre of Cardiology, Ministry of Health of Republic Uzbekistan , Tashkent ,","place":["Uzbekistan"]}]},{"given":"Erik","family":"Stroes","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine, D3.330, AMC , Meibergdreef 9, Amsterdam 1105 AZ ,","place":["The Netherlands"]}]},{"given":"Ta-Chen","family":"Su","sequence":"additional","affiliation":[{"name":"Departments of Environmental and Occupational Medicine, and Internal Medicine (Cardiology Division), National Taiwan University Hospital , Taipei ,","place":["Taiwan"]}]},{"given":"Tavintharan","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Admiralty Medical Centre and Khoo Teck Puat Hospital , Yishun Health ,","place":["Singapore"]}]},{"given":"Andrey V","family":"Susekov","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Educational Institution of Further Professional Education \u201cRussian Medical Academy of Continuous Professional Education\u201d of the Ministry of Healthcare of the Russian Federation , Moscow ,","place":["Russia"]}]},{"given":"Myra","family":"Tilney","sequence":"additional","affiliation":[{"name":"Lipid Clinic, Mater Dei Hospital , Msida ,","place":["Malta"]},{"name":"Faculty of Medicine and Surgery, Department of Medicine, University of Malta , Msida ,","place":["Malta"]}]},{"given":"Brian","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Macau University of Science and Technology , Macau ,","place":["China"]}]},{"given":"Thanh Huong","family":"Truong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Phenikaa University, Vietnam Atherosclerosis Society , Hanoi ,","place":["Vietnam"]}]},{"given":"Alexandros D","family":"Tselepis","sequence":"additional","affiliation":[{"name":"Atherothrombosis Research Centre, University of Ioannina , Ioannina ,","place":["Greece"]}]},{"given":"Anne","family":"Tybj\u00e6rg-Hansen","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Copenhagen University Hospital, University of Copenhagen , Copenhagen ,","place":["Denmark"]}]},{"given":"Alejandra","family":"V\u00e1zquez-C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Departamento Acad\u00e9mico Ciclo de Vida, Universidad 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