{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:09:46Z","timestamp":1776852586440,"version":"3.51.2"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"39","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Artery Society"},{"name":"Fondation Universit\u00e9 de Paris"},{"DOI":"10.13039\/501100001961","name":"AXA research fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001961","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation Hopitaux de Paris-Hopitaux de France"},{"name":"M\u00e9c\u00e9nat du GH APHP"},{"DOI":"10.13039\/501100002862","name":"CUP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002862","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation for the research in Physiology and DMU BioPhyGen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Increasing evidence suggests that COVID-19 survivors experience long-term cardiovascular complications possibly through development of vascular damage. The study aimed to investigate whether accelerated vascular ageing occurs after COVID-19 infection, and if so, identify its determinants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This prospective, multicentric, cohort study, included 34 centres in 16 countries worldwide, in 4 groups of participants\u2014COVID-19-negative controls (\u2170) and three groups of individuals with recent (6 \u00b1 3 months) exposure to SARS-CoV-2: not hospitalized (\u2171), hospitalized in general wards (\u2172), and hospitalized in intensive care units (\u2173). The main outcome was carotid-femoral pulse wave velocity (PWV), an established biomarker of large artery stiffness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>2390 individuals (age 50 \u00b1 15 years, 49.2% women) were recruited. After adjustment for confounders, all COVID-19-positive groups showed higher PWV (+0.41, +0.37, and +0.40\u2005m\/s for groups 2\u20134, P &amp;lt; .001, P = .001 and P = .003) vs. controls [PWV 7.53 (7.09; 7.97) m\/s adjusted mean (95% CI)]. In sex-stratified analyses, PWV differences were significant in women [PWV (+0.55, +0.60, and +1.09\u2005m\/s for groups 2\u20134, P &amp;lt; .001 for all)], but not in men. Among COVID-19 positive women, persistent symptoms were associated with higher PWV, regardless of disease severity and cardiovascular confounders [adjusted PWV 7.52 (95% CI 7.09; 7.96) vs. 7.13 (95% CI 6.67; 7.59) m\/s, P &amp;lt; .001]. A stable or improved PWV after 12 months was found in the COVID+ groups, whereas a progression was observed in the COVID\u2212 group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>COVID-19 is associated with early vascular ageing in the long term, especially in women.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurheartj\/ehaf430","type":"journal-article","created":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T23:06:09Z","timestamp":1755471969000},"page":"3905-3918","source":"Crossref","is-referenced-by-count":18,"title":["Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study"],"prefix":"10.1093","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6107-3356","authenticated-orcid":false,"given":"Rosa Maria","family":"Bruno","sequence":"first","affiliation":[{"name":"INSERM U970, Paris Cardiovascular Research Centre\u2014PARCC, 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