{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:20:28Z","timestamp":1773465628631,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>A cardio-oncology rehabilitation model among cancer survivors showed superior results compared with those of a community-based exercise intervention. However, questions remain about its cost-effectiveness. This study aims to assess the cost-effectiveness of a centre-based cardiac rehabilitation (CBCR) programme when compared to usual care encompassing a community-based exercise training (CBET), among cancer survivors with high cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The CORE study was a single-centre, prospective, randomized controlled trial; 80 adult cancer survivors with previous exposure to cardiotoxic cancer treatment and\/or with previous cardiovascular disease were assigned (1:1 ratio) to an 8-week CBCR or CBET, twice\/week. Cost-effectiveness was a pre-specified secondary endpoint. Outcomes included healthcare resource use and costs, quality-adjusted life-years (QALYs), and cost-effectiveness; the incremental cost-effectiveness ratio (ICER) was computed from a societal perspective. A total of 75 patients completed the study (CBCR n = 38; CBET n = 37). The CBCR group had a significantly higher cost per patient (477.76 \u00b1 39.08\u20ac) compared to the CBET group (339.32 \u00b1 53.88\u20ac), with a significant between-group difference of 138.44\u20ac [95% confidence interval (CI), 116.82\u2013160.05\u20ac, P &amp;lt; 0.01]. A between-group difference of 0.100 points in QALYs was observed, favouring CBCR (95% CI, \u22120.163 to \u22120.037, P = 0.002). When CBCR was compared with CBET, the ICER was \u20ac1383.24 per QALY gained; at a willingness-to-pay threshold of \u20ac5000 per QALY, the probability of CBCR being cost-effective was 99.9% (95% CI, 99.4\u2013100.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The CORE trial shows that CBCR is a cost-effective intervention in the management of cancer survivors with high cardiovascular risk, reinforcing the potential benefits of this multidisciplinary approach in supportive care of this specific subset of cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov: NCT05132998<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/eurjpc\/zwae181","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:41:57Z","timestamp":1716424917000},"page":"566-573","source":"Crossref","is-referenced-by-count":7,"title":["Cost-effectiveness analysis of a cardio-oncology rehabilitation framework compared to an exercise intervention for cancer survivors with high cardiovascular risk"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-9256","authenticated-orcid":false,"given":"Sofia G","family":"Viamonte","sequence":"first","affiliation":[{"name":"Centro de Reabilita\u00e7\u00e3o do Norte, Centro Hospitalar Vila Nova de Gaia\/Espinho , Avenida Infante Sagres n\u00b0 22, 4250-076 Vila Nova de Gaia ,","place":["Portugal"]},{"name":"ONCOMOVE\u00ae\u2014Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO) , 4410-406 Vila Nova de Gaia ,","place":["Portugal"]}]},{"given":"Aida","family":"Tavares","sequence":"additional","affiliation":[{"name":"Lisbon School of Economics and Management, University of Lisbon , 2775-405 Lisbon ,","place":["Portugal"]},{"name":"Center for Health Studies and Research, University of Coimbra , 3004-512 Coimbra ,","place":["Portugal"]}]},{"given":"Alberto J","family":"Alves","sequence":"additional","affiliation":[{"name":"ONCOMOVE\u00ae\u2014Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO) , 4410-406 Vila Nova de Gaia ,","place":["Portugal"]},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development, University of Maia , Maia ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7064-9639","authenticated-orcid":false,"given":"Ana","family":"Joaquim","sequence":"additional","affiliation":[{"name":"ONCOMOVE\u00ae\u2014Associa\u00e7\u00e3o de Investiga\u00e7\u00e3o de Cuidados de Suporte em Oncologia (AICSO) , 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