{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:44:13Z","timestamp":1768074253928,"version":"3.49.0"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, Portugal","award":["POCI-01-0145-FEDER-028014"],"award-info":[{"award-number":["POCI-01-0145-FEDER-028014"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, Portugal","award":["SFRH\/BD\/128612\/2017"],"award-info":[{"award-number":["SFRH\/BD\/128612\/2017"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, Portugal","award":["COVID\/BD\/152580\/2022"],"award-info":[{"award-number":["COVID\/BD\/152580\/2022"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, Portugal","award":["2020.01405.CEECIND\/CP1601\/CT0011"],"award-info":[{"award-number":["2020.01405.CEECIND\/CP1601\/CT0011"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia, Portugal","award":["UIDB\/50027\/2020"],"award-info":[{"award-number":["UIDB\/50027\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High altitude imposes several extreme constraints on life, such as low oxygen pressure and high levels of ultraviolet radiation, which require specialized adaptations. Many studies have focused on how endothermic vertebrates respond to these challenging environments, but there is still uncertainty on how ectotherms adapt to these conditions. Here, we used whole-genome sequencing of low-altitude (100\u2013600 m) and high-altitude (3,550 m) populations of the wide-ranging Tenerife lizard Gallotia galloti to uncover signatures of selection for altitudinal adaptation. The studied populations show reduced differentiation, sharing similar patterns of genetic variation. Selective sweep mapping suggests that signatures of adaptation to high altitude are not widespread across the genome, clustering in a relatively small number of genomic regions. One of these regions contains BMPER, a gene involved with vascular remodeling, and that has been associated with hypoxia-induced angiogenic response. By genotyping samples across 2 altitudinal transects, we show that allele frequency changes at this locus are not gradual, but rather show a well-defined shift above ca. 1,900 m. Transcript and protein structure analyses on this gene suggest that putative selection likely acts on noncoding variation. These results underline how low oxygen pressure generates the most consistent selective constraint in high-altitude environments, to which vertebrates with vastly contrasting physiological profiles need to adapt in the context of ongoing climate change.<\/jats:p>","DOI":"10.1093\/evlett\/qrae047","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T09:06:00Z","timestamp":1727082360000},"page":"41-50","source":"Crossref","is-referenced-by-count":2,"title":["Selection on the vascular-remodeling <i>BMPER<\/i> gene is associated with altitudinal adaptation in an insular lizard"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0207-8437","authenticated-orcid":false,"given":"Nina","family":"Ser\u00e9n","sequence":"first","affiliation":[{"name":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Geneticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto , Vair\u00e3o ,","place":["Portugal"]},{"name":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o , Vair\u00e3o ,","place":["Portugal"]},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto , Porto ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-2850","authenticated-orcid":false,"given":"Catarina","family":"Pinho","sequence":"additional","affiliation":[{"name":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Geneticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto , Vair\u00e3o ,","place":["Portugal"]},{"name":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o , Vair\u00e3o ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1038-0468","authenticated-orcid":false,"given":"Rodrigo","family":"Meg\u00eda-Palma","sequence":"additional","affiliation":[{"name":"Department of Biodiversity, Ecology and Evolution, Faculty of Biology, Universidad Complutense de Madrid (UCM) , Madrid ,","place":["Spain"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7838-644X","authenticated-orcid":false,"given":"Prem","family":"Aguilar","sequence":"additional","affiliation":[{"name":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Geneticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto , Vair\u00e3o ,","place":["Portugal"]},{"name":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o , Vair\u00e3o ,","place":["Portugal"]},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto , Porto ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2165-417X","authenticated-orcid":false,"given":"Anamarija","family":"\u017dagar","sequence":"additional","affiliation":[{"name":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Geneticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto , Vair\u00e3o ,","place":["Portugal"]},{"name":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o , Vair\u00e3o ,","place":["Portugal"]},{"name":"Department of Organisms and Ecosystems Research, National Institute of Biology , Ljubljana ,","place":["Slovenia"]},{"name":"Biotechnical Faculty, University of Ljubljana , Ljubljana ,","place":["Slovenia"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2540-2471","authenticated-orcid":false,"given":"Pedro","family":"Andrade","sequence":"additional","affiliation":[{"name":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Geneticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto , Vair\u00e3o ,","place":["Portugal"]},{"name":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o , Vair\u00e3o ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2335-7198","authenticated-orcid":false,"given":"Miguel A","family":"Carretero","sequence":"additional","affiliation":[{"name":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Geneticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto , Vair\u00e3o ,","place":["Portugal"]},{"name":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o , Vair\u00e3o ,","place":["Portugal"]},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto , Porto ,","place":["Portugal"]}]}],"member":"286","published-online":{"date-parts":[[2024,9,22]]},"reference":[{"issue":"12","key":"2025020321413008800_CIT0001","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.1073\/pnas.1820320116","article-title":"Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard","volume":"116","author":"Andrade","year":"2019","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"2025020321413008800_CIT0002","doi-asserted-by":"crossref","DOI":"10.1093\/acprof:oso\/9780198570875.001.1","volume-title":"Thermal adaptation: A theoretical and empirical synthesis","author":"Angilletta","year":"2009"},{"issue":"1","key":"2025020321413008800_CIT0003","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1146\/annurev.ph.49.030187.002341","article-title":"Cardiovascular responses to chronic hypoxia","volume":"49","author":"Banchero","year":"1987","journal-title":"Annual Review of Physiology"},{"key":"2025020321413008800_CIT0004","doi-asserted-by":"crossref","DOI":"10.1201\/9781498782739","volume-title":"Behavior of lizards: Evolutionary and mechanistic perspectives","author":"Bels","year":"2019"},{"issue":"2","key":"2025020321413008800_CIT0005","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/s1011-1344(96)00018-8","article-title":"Increase in solar UV radiation with altitude","volume":"39","author":"Blumthaler","year":"1997","journal-title":"Journal of Photochemistry and Photobiology B: Biology"},{"issue":"15","key":"2025020321413008800_CIT0006","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"2025020321413008800_CIT0007","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1186\/2047-217X-2-10","article-title":"Assemblathon 2: Evaluating de novo methods of genome assembly in three vertebrate species","volume":"2","author":"Bradnam","year":"2013","journal-title":"GigaScience"},{"issue":"11","key":"2025020321413008800_CIT0008","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1093\/gbe\/evw268","article-title":"Genomic signatures of historical allopatry and ecological divergence in an island lizard","volume":"8","author":"Brown","year":"2016","journal-title":"Genome Biology and Evolution"},{"issue":"3","key":"2025020321413008800_CIT0009","doi-asserted-by":"publisher","first-page":"344","DOI":"10.2307\/1564092","article-title":"Karyotype and chromosome structure in the lizard, Gallotia galloti in the Canary Islands","volume":"18","author":"Cano","year":"1984","journal-title":"Journal of Herpetology"},{"issue":"9\u201310","key":"2025020321413008800_CIT0010","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1130\/B26087.1","article-title":"Eruptive and structural history of Teide Volcano and rift zones of Tenerife, Canary Islands","volume":"119","author":"Carracedo","year":"2007","journal-title":"Geological Society of America Bulletin"},{"issue":"6","key":"2025020321413008800_CIT0011","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.medine.2018.05.013","article-title":"A journey between high altitude hypoxia and critical patient hypoxia: What can it teach us about compression and the management of critical disease","volume":"42","author":"Chavala","year":"2018","journal-title":"Medicina Intensiva (English Edition)"},{"issue":"20","key":"2025020321413008800_CIT0012","doi-asserted-by":"publisher","first-page":"4556","DOI":"10.1111\/j.1365-294X.2008.03942.x","article-title":"Transcriptomic variation and plasticity in rufous - collared sparrows (Zonotrichia capensis) along an altitudinal gradient","volume":"17","author":"Cheviron","year":"2008","journal-title":"Molecular Ecology"},{"issue":"5","key":"2025020321413008800_CIT0013","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41559-022-01703-4","article-title":"High-altitude adaptation and incipient speciation in geladas","volume":"6","author":"Chiou","year":"2022","journal-title":"Nature Ecology & Evolution"},{"issue":"2","key":"2025020321413008800_CIT0014","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3","volume":"6","author":"Cingolani","year":"2012","journal-title":"Fly"},{"issue":"9","key":"2025020321413008800_CIT0015","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1111\/1365-2435.14114","article-title":"Active regulation of ultraviolet light exposure overrides thermal preference behaviour in eastern fence lizards","volume":"36","author":"Conley","year":"2022","journal-title":"Functional Ecology"},{"issue":"2","key":"2025020321413008800_CIT0016","doi-asserted-by":"publisher","first-page":"giab008","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"issue":"5","key":"2025020321413008800_CIT0017","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: Multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Research"},{"key":"2025020321413008800_CIT0018","first-page":"46","article-title":"Sobre la presencia de Gallotia galloti en el pico del volc\u00e1n Teide (Tenerife, Islas Canarias)","volume":"22","author":"Fari\u00f1a","year":"2011","journal-title":"Bolet\u00edn de la Asociaci\u00f3n Herpetol\u00f3gica Espa\u00f1ola"},{"issue":"17","key":"2025020321413008800_CIT0019","doi-asserted-by":"publisher","first-page":"9451","DOI":"10.1073\/pnas.1921046117","article-title":"RepeatModeler2 for automated genomic discovery of transposable element families","volume":"117","author":"Flynn","year":"2020","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"2025020321413008800_CIT0020","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1161\/01.RES.0000181152.65534.07","article-title":"Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension","volume":"97","author":"Frank","year":"2005","journal-title":"Circulation Research"},{"issue":"5","key":"2025020321413008800_CIT0021","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1093\/molbev\/msy030","article-title":"Signatures of selection on standing genetic variation underlie athletic and navigational performance in racing pigeons","volume":"35","author":"Gazda","year":"2018","journal-title":"Molecular Biology and Evolution"},{"issue":"3","key":"2025020321413008800_CIT0022","doi-asserted-by":"crossref","first-page":"e0300111","DOI":"10.1371\/journal.pone.0300111","article-title":"Environmental factors influence cross-talk between a heat shock protein and an oxidative stress protein modification in the lizard Gallotia galloti","volume":"19","author":"Gilbert","year":"2024","journal-title":"PLoS One"},{"issue":"6","key":"2025020321413008800_CIT0023","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1086\/694833","article-title":"A mountain or a plateau? Hematological traits vary nonlinearly with altitude in a highland lizard","volume":"90","author":"Gonz\u00e1lez-Morales","year":"2017","journal-title":"Physiological and Biochemical Zoology: PBZ"},{"key":"2025020321413008800_CIT0024","doi-asserted-by":"crossref","first-page":"111338","DOI":"10.1016\/j.cbpa.2022.111338","article-title":"Elevation and blood traits in the mesquite lizard: Are patterns repeatable between mountains","volume":"276","author":"Gonz\u00e1lez-Morales","year":"2023","journal-title":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"},{"issue":"1","key":"2025020321413008800_CIT0025","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1093\/biolinnean\/blaa176","article-title":"To be small and dark is advantageous for gaining heat in mezquite lizards, Sceloporus grammicus (Squamata: Phrynosomatidae)","volume":"132","author":"Gonz\u00e1lez-Morales","year":"2021","journal-title":"Biological Journal of the Linnean Society"},{"issue":"Suppl 1","key":"2025020321413008800_CIT0026","doi-asserted-by":"publisher","first-page":"S162","DOI":"10.1002\/elps.200900140","article-title":"Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective","volume":"30","author":"Guex","year":"2009","journal-title":"Electrophoresis"},{"issue":"1","key":"2025020321413008800_CIT0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2008-9-1-r7","article-title":"Automated eukaryotic gene structure annotation using EvidenceModeler and the Program to Assemble Spliced Alignments","volume":"9","author":"Haas","year":"2008","journal-title":"Genome Biology"},{"key":"2025020321413008800_CIT0028","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/jeb.13262","article-title":"Trait differentiation and adaptation of plants along elevation gradients","volume":"31","author":"Halbritter","year":"2018","journal-title":"Journal of Evolutionary Biology"},{"issue":"8","key":"2025020321413008800_CIT0029","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1161\/CIRCRESAHA.108.178434","article-title":"BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4\u2013dependent angiogenesis","volume":"103","author":"Heinke","year":"2008","journal-title":"Circulation Research"},{"issue":"1","key":"2025020321413008800_CIT0030","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/1471-2148-13-273","article-title":"A genome wide study of genetic adaptation to high altitude in feral Andean Horses of the p\u00e1ramo","volume":"13","author":"Hendrickson","year":"2013","journal-title":"BMC Evolutionary Biology"},{"issue":"3\u20134","key":"2025020321413008800_CIT0031","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/s00421-003-0872-9","article-title":"Performing at extreme altitude: Muscle cellular and subcellular adaptations","volume":"90","author":"Howald","year":"2003","journal-title":"European Journal of Applied Physiology"},{"issue":"7513","key":"2025020321413008800_CIT0032","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature13408","article-title":"Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA","volume":"512","author":"Huerta-S\u00e1nchez","year":"2014","journal-title":"Nature"},{"key":"2025020321413008800_CIT0033","first-page":"29","article-title":"Structural and","volume-title":"Gene prediction","author":"Humann","year":"2019"},{"issue":"3","key":"2025020321413008800_CIT0034","doi-asserted-by":"publisher","first-page":"20200873","DOI":"10.1098\/rsbl.2020.0873","article-title":"Effects of hypoxia on the thermal physiology of a high-elevation lizard: Implications for upslope-shifting species","volume":"17","author":"Jiang","year":"2021","journal-title":"Biology Letters"},{"key":"2025020321413008800_CIT0035","author":"J\u00f8rgensen","year":"2008"},{"issue":"1","key":"2025020321413008800_CIT0036","doi-asserted-by":"publisher","first-page":"e15925","DOI":"10.1371\/journal.pone.0015925","article-title":"PoPoolation: A toolbox for population genetic analysis of next generation sequencing data from pooled individuals","volume":"6","author":"Kofler","year":"2011","journal-title":"PLoS One"},{"issue":"24","key":"2025020321413008800_CIT0037","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1093\/bioinformatics\/btr589","article-title":"PoPoolation2: Identifying differentiation between populations using sequencing of pooled DNA samples (Pool-Seq)","volume":"27","author":"Kofler","year":"2011","journal-title":"Bioinformatics"},{"issue":"22","key":"2025020321413008800_CIT0038","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1093\/bioinformatics\/btu531","article-title":"AliView: A fast and lightweight alignment viewer and editor for large datasets","volume":"30","author":"Larsson","year":"2014","journal-title":"Bioinformatics"},{"key":"2025020321413008800_CIT0039","doi-asserted-by":"publisher","first-page":"1","DOI":"10.48550\/arXiv.1303.3997","article-title":"Aligning sequence reads, clone sequences and assembly contigs with BWAMEM","author":"Li","year":"2013","journal-title":"ArXiv"},{"issue":"33","key":"2025020321413008800_CIT0040","doi-asserted-by":"publisher","first-page":"8406","DOI":"10.1073\/pnas.1805348115","article-title":"Comparative genomic investigation of high-elevation adaptation in ectothermic snakes","volume":"115","author":"Li","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"2025020321413008800_CIT0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12915-023-01535-z","article-title":"Chromosome-level genome assembly and population genomics of Mongolian racerunner (Eremias argus) provide insights into high-altitude adaptation in lizards","volume":"21","author":"Li","year":"2023","journal-title":"BMC Biology"},{"issue":"11","key":"2025020321413008800_CIT0042","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1093\/molbev\/msz158","article-title":"EPAS1 gain-of-function mutation contributes to high-altitude adaptation in Tibetan horses","volume":"36","author":"Liu","year":"2019","journal-title":"Molecular Biology and Evolution"},{"issue":"5","key":"2025020321413008800_CIT0043","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/hdy.2015.42","article-title":"Properties of different selection signature statistics and a new strategy for combining them","volume":"115","author":"Ma","year":"2015","journal-title":"Heredity"},{"issue":"4","key":"2025020321413008800_CIT0044","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1152\/physrev.1991.71.4.1135","article-title":"Physiological adaptation to high altitude: Oxygen transport in mammals and birds","volume":"71","author":"Monge","year":"1991","journal-title":"Physiological Reviews"},{"issue":"S1","key":"2025020321413008800_CIT0045","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/evo.14388","article-title":"The Bogert effect, a factor in evolution","volume":"76","author":"Mu\u00f1oz","year":"2021","journal-title":"Evolution"},{"key":"2025020321413008800_CIT0046","doi-asserted-by":"crossref","DOI":"10.7312\/nei-92038","volume-title":"Molecular evolutionary genetics","author":"Nei","year":"1987"},{"issue":"8","key":"2025020321413008800_CIT0047","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1111\/gcb.12240","article-title":"Temperature variation makes ectotherms more sensitive to climate change","volume":"19","author":"Paaijmans","year":"2013","journal-title":"Global Change Biology"},{"key":"2025020321413008800_CIT0048","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3389\/fgene.2020.00743","article-title":"Cross-species insights into genomic adaptations to hypoxia","volume":"11","author":"Pamenter","year":"2020","journal-title":"Frontiers in Genetics"},{"issue":"1","key":"2025020321413008800_CIT0049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms3071","article-title":"Ground tit genome reveals avian adaptation to living at high altitudes in the Tibetan plateau","volume":"4","author":"Qu","year":"2013","journal-title":"Nature Communications"},{"key":"2025020321413008800_CIT0050","first-page":"189","article-title":"Gut microbiota composition in Himalayan and Andean populations and its relationship with diet, lifestyle and adaptation to the high-altitude environment","volume":"96","author":"Quagliariello","year":"2019","journal-title":"Journal of Anthropological Sciences"},{"issue":"2","key":"2025020321413008800_CIT0051","first-page":"139","article-title":"Ecophysiological conservativeness and size-mediated plasticity in the High Mountain Lizard Atlantolacerta andreanskyi confirm its vulnerability to climate change","volume":"58","author":"S\u2019khifa","year":"2022","journal-title":"SALAMANDRA"},{"issue":"3","key":"2025020321413008800_CIT0052","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/jzo.12744","article-title":"Variation in field body temperature and total evaporative water loss along an environmental gradient in a diurnal ectotherm","volume":"310","author":"Sannolo","year":"2020","journal-title":"Journal of Zoology"},{"issue":"11","key":"2025020321413008800_CIT0053","doi-asserted-by":"publisher","first-page":"e1008420","DOI":"10.1371\/journal.pgen.1008420","article-title":"Physiological and genomic evidence that selection on the transcription factor Epas1 has altered cardiovascular function in high-altitude deer mice","volume":"15","author":"Schweizer","year":"2019","journal-title":"PLoS Genetics"},{"key":"2025020321413008800_CIT0054","doi-asserted-by":"publisher","DOI":"10.1111\/jbi.14711","article-title":"Functional responses in a lizard along a 3.5-km altitudinal gradient","author":"Ser\u00e9n","year":"2023","journal-title":"Journal of Biogeography"},{"issue":"19","key":"2025020321413008800_CIT0055","doi-asserted-by":"publisher","first-page":"3210","DOI":"10.1093\/bioinformatics\/btv351","article-title":"BUSCO: Assessing genome assembly and annotation completeness with single-copy orthologs","volume":"31","author":"Sim\u00e3o","year":"2015","journal-title":"Bioinformatics"},{"issue":"5987","key":"2025020321413008800_CIT0056","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1126\/science.1189406","article-title":"Genetic evidence for high-altitude adaptation in Tibet","volume":"329","author":"Simonson","year":"2010","journal-title":"Science"},{"issue":"5980","key":"2025020321413008800_CIT0057","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1126\/science.1184695","article-title":"Erosion of lizard diversity by climate change and altered thermal niches","volume":"328","author":"Sinervo","year":"2010","journal-title":"Science"},{"key":"2025020321413008800_CIT0058","author":"Smit","year":"2013"},{"key":"2025020321413008800_CIT0059","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jtherbio.2016.04.007","article-title":"Thermal ecology of montane Atelopus (Anura: Bufonidae): A study of intrageneric diversity","volume":"58","author":"Solano","year":"2016","journal-title":"Journal of Thermal Biology"},{"issue":"6","key":"2025020321413008800_CIT0060","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/1749-4877.12468","article-title":"High-elevation hypoxia impacts perinatal physiology and performance in a potential montane colonizer","volume":"15","author":"Souchet","year":"2020","journal-title":"Integrative Zoology"},{"issue":"6","key":"2025020321413008800_CIT0061","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1161\/ATVBAHA.119.312665","article-title":"Role of TPBG (trophoblast glycoprotein) antigen in human pericyte migratory and angiogenic activity","volume":"39","author":"Spencer","year":"2019","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"Web Server issue","key":"2025020321413008800_CIT0062","doi-asserted-by":"publisher","first-page":"W435","DOI":"10.1093\/nar\/gkl200","article-title":"AUGUSTUS: AB initio prediction of alternative transcripts","volume":"34","author":"Stanke","year":"2006","journal-title":"Nucleic Acids Research"},{"key":"2025020321413008800_CIT0063","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1146\/annurev-ecolsys-110218-025014","article-title":"Life ascending: Mechanism and process in physiological adaptation to high-altitude hypoxia","volume":"50","author":"Storz","year":"2019","journal-title":"Annual Review of Ecology, Evolution, and Systematics"},{"issue":"6","key":"2025020321413008800_CIT0064","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.2144\/00286ir01","article-title":"The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences","volume":"28","author":"Stothard","year":"2000","journal-title":"Biotechniques"},{"issue":"45","key":"2025020321413008800_CIT0065","doi-asserted-by":"publisher","first-page":"E10634","DOI":"10.1073\/pnas.1813593115","article-title":"Species groups distributed across elevational gradients reveal convergent and continuous genetic adaptation to high elevations","volume":"115","author":"Sun","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"2025020321413008800_CIT0066","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1093\/genetics\/123.3.585","article-title":"Statistical method for testing the neutral mutation hypothesis by DNA polymorphism","volume":"123","author":"Tajima","year":"1989","journal-title":"Genetics"},{"issue":"4","key":"2025020321413008800_CIT0067","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1203\/pdr.0b013e3180332cba","article-title":"Hypoxia induces alteration of bone morphogenetic protein receptor signaling in pulmonary artery endothelial cell","volume":"61","author":"Takahashi","year":"2007","journal-title":"Pediatric Research"},{"issue":"11","key":"2025020321413008800_CIT0068","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1111\/gcb.12581","article-title":"Climate variability and vulnerability to climate change: A review","volume":"20","author":"Thornton","year":"2014","journal-title":"Global Change Biology"},{"issue":"2","key":"2025020321413008800_CIT0069","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative Genomics Viewer (IGV): High-performance genomics data visualization and exploration","volume":"14","author":"Thorvaldsd\u00f3ttir","year":"2013","journal-title":"Briefings in Bioinformatics"},{"issue":"8","key":"2025020321413008800_CIT0070","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1093\/molbev\/msaa086","article-title":"Adaptive shifts in gene regulation underlie a developmental delay in thermogenesis in high-altitude deer mice","volume":"37","author":"Velotta","year":"2020","journal-title":"Molecular Biology and Evolution"},{"issue":"2","key":"2025020321413008800_CIT0071","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0300-9629(72)90190-9","article-title":"The effects of altitude on oxygen-binding parameters of the blood of the iguanid lizards, Sceloporus jarrovi and Sceloporus occidentals","volume":"43","author":"Vinegar","year":"1972","journal-title":"Comparative Biochemistry and Physiology Part A: Physiology"},{"issue":"1","key":"2025020321413008800_CIT0072","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1017\/S1751731113001948","article-title":"Profiling of the yak skeletal muscle tissue gene expression and comparison with the domestic cattle by genome array","volume":"8","author":"Wang","year":"2014","journal-title":"Animal"},{"issue":"7","key":"2025020321413008800_CIT0073","first-page":"4470","article-title":"ENO1 silencing impaires hypoxia-induced gemcitabine chemoresistance associated with redox modulation in pancreatic cancer cells","volume":"11","author":"Wang","year":"2019","journal-title":"American Journal of Translational Research"},{"issue":"17","key":"2025020321413008800_CIT0074","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.1016\/j.cub.2021.06.062","article-title":"Genomic basis of high-altitude adaptation in Tibetan Prunus fruit trees","volume":"31","author":"Wang","year":"2021","journal-title":"Current Biology: CB"},{"issue":"W1","key":"2025020321413008800_CIT0075","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: Homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"2025020321413008800_CIT0076","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1101\/gr.214874.116","article-title":"Direct determination of diploid genome sequences","volume":"27","author":"Weisenfeld","year":"2017","journal-title":"Genome Research"},{"issue":"1777","key":"2025020321413008800_CIT0077","doi-asserted-by":"publisher","first-page":"20180235","DOI":"10.1098\/rstb.2018.0235","article-title":"Convergent evolution in human and domesticate adaptation to high-altitude environments","volume":"374","author":"Witt","year":"2019","journal-title":"Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences"},{"issue":"8","key":"2025020321413008800_CIT0078","doi-asserted-by":"publisher","first-page":"13738","DOI":"10.3390\/ijms150813738","article-title":"BMP4 protects rat pulmonary arterial smooth muscle cells from apoptosis by PI3K\/AKT\/Smad1\/5\/8 signaling","volume":"15","author":"Wu","year":"2014","journal-title":"International Journal of Molecular Sciences"},{"issue":"16","key":"2025020321413008800_CIT0079","doi-asserted-by":"publisher","first-page":"4189","DOI":"10.1073\/pnas.1617042114","article-title":"Genetic signatures of high-altitude adaptation in Tibetans","volume":"114","author":"Yang","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"2025020321413008800_CIT0080","doi-asserted-by":"publisher","first-page":"e112218","DOI":"10.1371\/journal.pone.0112218","article-title":"Exploring the genetic basis of adaptation to high elevations in reptiles: a comparative transcriptome analysis of two toad-headed agamas (genus Phrynocephalus)","volume":"9","author":"Yang","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"2025020321413008800_CIT0081","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12863-016-0440-z","article-title":"Genetic signals of high-altitude adaptation in amphibians: A comparative transcriptome analysis","volume":"17","author":"Yang","year":"2016","journal-title":"BMC Genetics"},{"issue":"1","key":"2025020321413008800_CIT0082","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12863-017-0529-z","article-title":"Gene expression variations in high-altitude adaptation: A case study of the Asiatic toad (Bufo gargarizans)","volume":"18","author":"Yang","year":"2017","journal-title":"BMC Genetics"},{"key":"2025020321413008800_CIT0083","doi-asserted-by":"publisher","first-page":"111233","DOI":"10.1016\/j.cbpa.2022.111233","article-title":"Parasitemia and elevation as predictors of hemoglobin concentration and antioxidant capacity in two sympatric lizards","volume":"270","author":"\u017dagar","year":"2022","journal-title":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"},{"issue":"3","key":"2025020321413008800_CIT0084","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/gbe\/evw032","article-title":"Genome resequencing identifies unique adaptations of Tibetan chickens to hypoxia and high-dose ultraviolet radiation in high-altitude environments","volume":"8","author":"Zhang","year":"2016","journal-title":"Genome Biology and Evolution"},{"issue":"W1","key":"2025020321413008800_CIT0085","doi-asserted-by":"crossref","first-page":"W122","DOI":"10.1093\/nar\/gkad472","article-title":"DDMut: Predicting effects of mutations on protein stability using deep learning","volume":"51","author":"Zhou","year":"2023","journal-title":"Nucleic Acids Research"}],"container-title":["Evolution Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/evlett\/article-pdf\/9\/1\/41\/59238357\/qrae047.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/evlett\/article-pdf\/9\/1\/41\/59238357\/qrae047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T21:42:40Z","timestamp":1738618960000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/evlett\/article\/9\/1\/41\/7765167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,22]]},"references-count":85,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,9,22]]},"published-print":{"date-parts":[[2025,2,3]]}},"URL":"https:\/\/doi.org\/10.1093\/evlett\/qrae047","relation":{},"ISSN":["2056-3744"],"issn-type":[{"value":"2056-3744","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2024,9,22]]}}}