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Gup1 was previously shown to interact physically with the mitochondrial membrane VDAC (Voltage-Dependent Anion Channel) protein Por1 and the ammonium transceptor Mep2. By co-immunoprecipitation, the eisosome core component Pil1 was identified as a novel physical interaction partner of Gup1. The expression of PIL1 and Pil1 protein levels were found to be unaffected by GUP1 deletion. In \u2206gup1 cells, Pil1 was distributed in dots (likely representing eisosomes) in the membrane, identically to wt cells. However, \u2206gup1 cells presented 50% less Pil1-GFP dots\/eisosomes, suggesting that Gup1 is important for eisosome formation. The two proteins also interact genetically in the maintenance of cell wall integrity, and during arsenite and acetic acid exposure. We show that \u0394gup1 \u0394pil1 cells take up more arsenite than wt and are extremely sensitive to arsenite and to acetic acid treatments. The latter causes a severe apoptotic wt-like cell death phenotype, epistatically reverting the \u2206gup1 necrotic type of death. Gup1 and Pil1 are thus physically, genetically and functionally connected.<\/jats:p>","DOI":"10.1093\/femsyr\/foaa070","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T12:10:28Z","timestamp":1608552628000},"source":"Crossref","is-referenced-by-count":2,"title":["Physical, genetic and functional interactions between the eisosome protein Pil1 and the MBOAT <i>O<\/i>-acyltransferase Gup1"],"prefix":"10.1093","volume":"21","author":[{"given":"Joana","family":"Tulha","sequence":"first","affiliation":[{"name":"Centre of Molecular and Environmental Biology, University of Minho, Campus de Gualtar 4710-057 Braga, Portugal"}]},{"given":"Mariana","family":"Amorim-Rodrigues","sequence":"additional","affiliation":[{"name":"Centre of Molecular and Environmental Biology, University of Minho, Campus de Gualtar 4710-057 Braga, Portugal"},{"name":"Institute of Science and Innovation for Bio-Sustainability (IB-S), University of Minho, Campus de Gualtar 4710-057 Braga, Portugal"}]},{"given":"Lidia Alejo","family":"Esquembre","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology, University of Gothenburg, Kemihuset 412 96 Gothenburg, Sweden"}]},{"given":"Sebastien","family":"Rauch","sequence":"additional","affiliation":[{"name":"Water Environment Technology, Department of Architecture and Civil and Environmental Engineering, Chalmers University of Technology, S-412 96 Gothenburg, Sweden"}]},{"given":"Markus J","family":"Tam\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology, University of Gothenburg, Kemihuset 412 96 Gothenburg, Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8605-4525","authenticated-orcid":false,"given":"C\u00e2ndida","family":"Lucas","sequence":"additional","affiliation":[{"name":"Centre of Molecular and Environmental Biology, University of Minho, Campus de Gualtar 4710-057 Braga, Portugal"},{"name":"Institute of Science and 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