{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T22:55:50Z","timestamp":1758840950522,"version":"3.41.2"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006129","name":"FCT","doi-asserted-by":"publisher","award":["SFRH\/BD\/131637\/2017"],"award-info":[{"award-number":["SFRH\/BD\/131637\/2017"]}],"id":[{"id":"10.13039\/100006129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Candida albicans typically resides in the human gastrointestinal tract and mucosal membranes as a commensal organism. To adapt and cope with the host immune system, it has evolved a variety of mechanisms of adaptation such as stress-induced mutagenesis and epigenetic regulation. Niche-specific patterns of gene expression also allow the fungus to fine-tune its response to specific microenvironments in the host and switch from harmless commensal to invasive pathogen. Proteome plasticity produced by CUG ambiguity, on the other hand is emerging as a new layer of complexity in C. albicans adaptation, pathogenesis, and drug resistance. Such proteome plasticity is the result of a genetic code alteration where the leucine CUG codon is translated mainly as serine (97%), but maintains some level of leucine (3%) assignment. In this review, we dissect the link between C. albicans non-standard CUG translation, proteome plasticity, host adaptation and pathogenesis. We discuss published work showing how this pathogen uses the fidelity of protein synthesis to spawn novel virulence traits.<\/jats:p>","DOI":"10.1093\/femsyr\/foab032","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T19:16:32Z","timestamp":1621538192000},"source":"Crossref","is-referenced-by-count":7,"title":["The role of non-standard translation in <i>Candida albicans<\/i> pathogenesis"],"prefix":"10.1093","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-1711","authenticated-orcid":false,"given":"Ana Rita","family":"Bezerra","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Institute of Biomedicine \u2013 iBiMED, University of Aveiro , 3810-193 Aveiro, Portugal"}]},{"given":"Carla","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Institute of Biomedicine \u2013 iBiMED, University of Aveiro , 3810-193 Aveiro, Portugal"}]},{"given":"In\u00eas","family":"Correia","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Institute of Biomedicine \u2013 iBiMED, University of Aveiro , 3810-193 Aveiro, Portugal"}]},{"given":"Ana Rita","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Institute of Biomedicine \u2013 iBiMED, University of Aveiro , 3810-193 Aveiro, Portugal"}]},{"given":"Gon\u00e7alo","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Institute of Biomedicine \u2013 iBiMED, University of Aveiro , 3810-193 Aveiro, Portugal"}]},{"given":"Maria Jo\u00e3o","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Institute of Biomedicine \u2013 iBiMED, University of Aveiro , 3810-193 Aveiro, Portugal"}]},{"given":"Gabriela","family":"Moura","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, 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