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The molecular mechanisms underneath this production or the environmental factors modulating it remain unknown. Herein, we found that, unlike Saccharomyces cerevisiae, H. guilliermondii over-produces acetate esters and higher alcohols at low carbon-to-assimilable nitrogen (C:N) ratios, with the highest titers being obtained in the amino acid-enriched medium YPD. The evidences gathered support a model in which the strict preference of H. guilliermondii for amino acids as nitrogen sources results in a channeling of keto-acids obtained after transamination to higher alcohols and acetate esters. This higher production was accompanied by higher expression of the four HgAATs, genes, recently proposed to encode alcohol acetyl transferases. In silico analyses of these HgAat\u2019s reveal that they harbor conserved AATs motifs, albeit radical substitutions were identified that might result in different kinetic properties. Close homologues of HgAat2, HgAat3, and HgAat4 were only found in members of Hanseniaspora genus and phylogenetic reconstruction shows that these constitute a distinct family of Aat\u2019s. These results advance the exploration of H. guilliermondii as a bio-flavoring agent providing important insights to guide future strategies for strain engineering and media manipulation that can enhance production of aromatic volatiles.<\/jats:p>","DOI":"10.1093\/femsyr\/foad021","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T09:15:50Z","timestamp":1679735750000},"source":"Crossref","is-referenced-by-count":5,"title":["Insights into the transcriptional regulation of poorly characterized alcohol acetyltransferase-encoding genes (HgAATs) shed light into the production of acetate esters in the wine yeast <i>Hanseniaspora guilliermondii<\/i>"],"prefix":"10.1093","volume":"23","author":[{"given":"Isabel","family":"Seixas","sequence":"first","affiliation":[{"name":"WM&B\u2014Laboratory of Wine Microbiology & Biotechnology, Department of Biology and Environment, University of Tr\u00e1s-os-Montes and Alto Douro , 5000-801 Vila Real , Portugal"},{"name":"BioISI-Biosystems and Integrative Sciences Institute, Faculdade de Ci\u00eancias, Universidade de Lisboa Campo Grande , 1749-016 Lisbon , Portugal"}]},{"given":"Diogo","family":"Santos","sequence":"additional","affiliation":[{"name":"iBB, Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa , Avenida Rovisco Pais, 1049-001 Lisbon , Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy at Instituto Superior T\u00e9cnico, Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisboa , Portugal"}]},{"given":"Isabel","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"CBQF\/Centro de Biotecnologia e Qu\u00edmica Fina, Escola Superior de Biotecnologia, Universidade Cat\u00f3lica Portuguesa , 4169-005 Porto , Portugal"}]},{"given":"Nuno P","family":"Mira","sequence":"additional","affiliation":[{"name":"iBB, Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa , Avenida Rovisco Pais, 1049-001 Lisbon , Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy at Instituto Superior T\u00e9cnico, Universidade de Lisboa , Av. 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