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Disruptions of these ionic gradients can significantly impact membrane electrochemical potential and the balance of other ions, particularly under stressful conditions such as exposure to acetic acid. This weak acid, ubiquitous to both yeast metabolism and industrial processes, is a major inhibitor of yeast cell growth in industrial settings and a key determinant of host colonization by pathogenic yeast. Acetic acid toxicity depends on medium composition, especially on the pH (H+ concentration), but also on other ions\u2019 concentrations. Regulation of ion fluxes is essential for effective yeast response and adaptation to acetic acid stress. However, the intricate interplay among ion balancing systems and stress response mechanisms still presents significant knowledge gaps. This review offers a comprehensive overview of the mechanisms governing ion homeostasis, including H+, K+, Zn2+, Fe2+\/3+, and acetate, in the context of acetic acid toxicity, adaptation, and tolerance. While focus is given on Saccharomyces cerevisiae due to its extensive physiological characterization, insights are also provided for biotechnologically and clinically relevant yeast species whenever available.<\/jats:p>","DOI":"10.1093\/femsyr\/foae016","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T11:45:34Z","timestamp":1713872734000},"source":"Crossref","is-referenced-by-count":12,"title":["The role of ion homeostasis in adaptation and tolerance to acetic acid stress in yeasts"],"prefix":"10.1093","volume":"24","author":[{"given":"Miguel","family":"Antunes","sequence":"first","affiliation":[{"name":"iBB\u2014Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001, Lisbon ,","place":["Portugal"]},{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001, Lisbon ,","place":["Portugal"]},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy at Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001, Lisbon ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2208-5183","authenticated-orcid":false,"given":"Isabel","family":"S\u00e1-Correia","sequence":"additional","affiliation":[{"name":"iBB\u2014Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001, Lisbon ,","place":["Portugal"]},{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001, Lisbon ,","place":["Portugal"]},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy at Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001, Lisbon ,","place":["Portugal"]}]}],"member":"286","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"2024121916351384900_bib1","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/1873-3468.14330","article-title":"The toxic effects of 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