{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:44:19Z","timestamp":1760057059639,"version":"build-2065373602"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":260,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04565\/2020"],"award-info":[{"award-number":["UIDB\/04565\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015620","name":"Institute for Bioengineering and Biosciences","doi-asserted-by":"publisher","award":["LA\/P\/0140\/2020"],"award-info":[{"award-number":["LA\/P\/0140\/2020"]}],"id":[{"id":"10.13039\/501100015620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Candida glabrata is a prominent causative agent of mucosal and disseminated human infections. Part of the success of C. glabrata as a human pathogen relies on its adherence capacity and ability to tolerate\/surpass the activity of immune cells. Herein we describe the involvement of the transcription factor CgHaa1 and of its regulated genes CgAWP12, CgAWP13, CAGL0H07469\u00a0g, and CAGL0K10164\u00a0g in adherence of C. glabrata to vaginal cells in the presence of acetic acid, an organic acid usually found in this niche due to the activity of commensal bacteria. CgHaa1 and its target genes CgAWP12, CAGL0K10164\u00a0g and CAGL0E03740\u00a0g were also found to significantly increase C. glabrata-induced killing of the model wax moth Galleria mellonela, in part by modulating the interaction of the yeasts with the larvae\u2019s immune cells. Finally, we show that CgHAA1 expression reduces ingestion and subsequent killing of C. glabrata cells by THP-1 human macrophages. This demonstrated role of CgHaa1 in C. glabrata virulence and interaction with immune cells expands the biological role of this regulator positioning it (and its target genes) as a potential interesting candidate target for new therapies focused on reducing the burden of candidiasis.<\/jats:p>","DOI":"10.1093\/femsyr\/foaf054","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:28:00Z","timestamp":1758328080000},"source":"Crossref","is-referenced-by-count":0,"title":["The transcription factor CgHaa1 plays a role in virulence of the pathogenic yeast <i>Candida glabrata<\/i>"],"prefix":"10.1093","volume":"25","author":[{"given":"Sara Barbosa","family":"Salazar","sequence":"first","affiliation":[{"name":"Universidade de Lisboa iBB, Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico \u2013 Department of Bioengineering, , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]}]},{"given":"Nuno Alexandre","family":"Pedro","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa iBB, Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico \u2013 Department of Bioengineering, , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]}]},{"given":"S\u00f3nia","family":"Silva","sequence":"additional","affiliation":[{"name":"CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar , 4710-057 Braga,","place":["Portugal"]},{"name":"LABBELS - Associate Laboratory , 4710-057 Braga, Guimar\u00e3es ,","place":["Portugal"]}]},{"given":"Dalila","family":"Mil-Homens","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa iBB, Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico \u2013 Department of Bioengineering, , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-8515","authenticated-orcid":false,"given":"Andreia","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa iBB, Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico \u2013 Department of Bioengineering, , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]}]},{"given":"Marcin","family":"Wlodarczyk","sequence":"additional","affiliation":[{"name":"University of Lodz Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, , 90-237 \u0141\u00f3d\u017a ,","place":["Poland"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-7204","authenticated-orcid":false,"given":"Aleksandra","family":"Szwed-Georgiou","sequence":"additional","affiliation":[{"name":"University of Lodz Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, , 90-237 \u0141\u00f3d\u017a ,","place":["Poland"]}]},{"given":"Kaname","family":"Sasamoto","sequence":"additional","affiliation":[{"name":"Medical Mycology Research Center, Chiba University , Chiba 260-8673 ,","place":["Japan"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-5569","authenticated-orcid":false,"given":"Hiroji","family":"Chibana","sequence":"additional","affiliation":[{"name":"Medical Mycology Research Center, Chiba University , Chiba 260-8673 ,","place":["Japan"]}]},{"given":"Sylwia","family":"Michlewska","sequence":"additional","affiliation":[{"name":"Laboratory of Microscopic Imaging and Specialized Biological Techniques, Faculty of Biology and Environmental Protection, University of Lodz , 90-237 \u0141\u00f3d\u017a ,","place":["Poland"]}]},{"given":"Karolina","family":"Rudnicka","sequence":"additional","affiliation":[{"name":"University of Lodz Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, , 90-237 \u0141\u00f3d\u017a ,","place":["Poland"]}]},{"given":"Ars\u00e9nio","family":"Fialho","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa iBB, Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico \u2013 Department of Bioengineering, , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-0385","authenticated-orcid":false,"given":"Nuno Pereira","family":"Mira","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa iBB, Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico \u2013 Department of Bioengineering, , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Instituto Superior T\u00e9cnico, Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisboa ,","place":["Portugal"]}]}],"member":"286","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"2025100910271080200_bib1","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1080\/21505594.2017.1347744","article-title":"Galleria mellonella\u00a0as a host model to study Candida glabrata virulence and antifungal efficacy","volume":"8","author":"Ames","year":"2017","journal-title":"Virulence"},{"key":"2025100910271080200_bib2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1534\/g3.116.034660","article-title":"The CgHaa1-regulon mediates response and tolerance to acetic acid stress in the Human pathogen Candida glabrata","volume":"7","author":"Bernardo","year":"2017","journal-title":"G3"},{"key":"2025100910271080200_bib3","doi-asserted-by":"publisher","first-page":"5170","DOI":"10.1128\/IAI.67.10.5170-5175.1999","article-title":"Acid production by vaginal flora in vitro is consistent with the rate and extent of vaginal acidification","volume":"67","author":"Boskey","year":"1999","journal-title":"Infect Immun"},{"key":"2025100910271080200_bib4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00995-18","article-title":"A transcriptomics approach to unveiling the mechanisms of in vitro evolution towards fluconazole resistance of a Candida glabrata clinical isolate","volume":"63","author":"Cavalheiro","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"2025100910271080200_bib5","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/s42003-021-02412-7","article-title":"From the first touch to biofilm establishment by the human pathogen Candida glabrata: a genome-wide to nanoscale view","volume":"4","author":"Cavalheiro","year":"2021","journal-title":"Commun Biol"},{"key":"2025100910271080200_bib6","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fmed.2018.00028","article-title":"Candida biofilms: threats, challenges, and promising strategies","volume":"5","author":"Cavalheiro","year":"2018","journal-title":"Front Med"},{"key":"2025100910271080200_bib7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/jof4030108","article-title":"Standardization of G. mellonella larvae to provide reliable and reproducible results in the study of fungal pathogens","volume":"4","author":"Champion","year":"2018","journal-title":"J Fungi (Basel)"},{"key":"2025100910271080200_bib8","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/1471-2164-12-192","article-title":"FungalRV: adhesin prediction and immunoinformatics portal for human fungal pathogens","volume":"12","author":"Chaudhuri","year":"2011","journal-title":"BMC Genomics"},{"key":"2025100910271080200_bib9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2017.00259","article-title":"Mechanistic insights underlying tolerance to acetic acid stress in vaginal Candida glabrata clinical isolates","volume":"8","author":"Cunha","year":"2017","journal-title":"Front Microbiol"},{"key":"2025100910271080200_bib10","doi-asserted-by":"publisher","first-page":"fov056","DOI":"10.1093\/femsyr\/fov056","article-title":"Local and regional chromatin silencing in Candida glabrata: consequences for adhesion and the response to stress","volume":"15","author":"De\u00a0Las\u00a0Penas","year":"2015","journal-title":"FEMS Yeast Res"},{"key":"2025100910271080200_bib11","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1128\/IAI.00851-12","article-title":"Transcriptional profiling of Candida glabrata during phagocytosis by neutrophils and in the infected mouse spleen","volume":"81","author":"Fukuda","year":"2013","journal-title":"Infect Immun"},{"key":"2025100910271080200_bib12","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1042\/BCJ20200844","article-title":"Revealing Candida glabrata biofilm matrix proteome: global characterization and pH response","volume":"478","author":"Goncalves","year":"2021","journal-title":"Biochem J"},{"key":"2025100910271080200_bib13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.biochi.2023.01.011","article-title":"Sfl1 is required for Candida albicans biofilm formation under acidic conditions","volume":"209","author":"Goncalves","year":"2023","journal-title":"Biochimie"},{"key":"2025100910271080200_bib14","doi-asserted-by":"publisher","first-page":"151414","DOI":"10.1016\/j.ijmm.2020.151414","article-title":"Effect of progesterone on Candida albicans biofilm formation under acidic conditions: a transcriptomic analysis","volume":"310","author":"Goncalves","year":"2020","journal-title":"Int J Med Microbiol"},{"key":"2025100910271080200_bib15","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1080\/08927014.2020.1793963","article-title":"Environmental pH modulates biofilm formation and matrix composition in Candida albicans and Candida glabrata","volume":"36","author":"Goncalves","year":"2020","journal-title":"Biofouling"},{"key":"2025100910271080200_bib16","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1128\/EC.05232-11","article-title":"Heterogeneous expression of the virulence-related adhesin Epa1 between individual cells and strains of the pathogen Candida glabrata","volume":"11","author":"Halliwell","year":"2012","journal-title":"Euk Cell"},{"key":"2025100910271080200_bib17","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00294-015-0473-2","article-title":"The EPA2 adhesin encoding gene is responsive to oxidative stress in the opportunistic fungal pathogen Candida glabrata","volume":"61","author":"Juarez-Cepeda","year":"2015","journal-title":"Curr Genet"},{"key":"2025100910271080200_bib18","doi-asserted-by":"publisher","first-page":"e0002123","DOI":"10.1128\/mmbr.00021-23","article-title":"Candida albicans and Candida glabrata: global priority pathogens","volume":"88","author":"Katsipoulaki","year":"2024","journal-title":"Microbiol Mol Biol Rev"},{"key":"2025100910271080200_bib19","doi-asserted-by":"publisher","first-page":"7628","DOI":"10.1073\/pnas.0611195104","article-title":"A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata","volume":"104","author":"Kaur","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025100910271080200_bib20","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1080\/21505594.2018.1454172","article-title":"Generous hosts: why the larvae of greater wax moth, Galleria mellonella is a perfect infectious host model?","volume":"9","author":"Killiny","year":"2018","journal-title":"Virulence"},{"key":"2025100910271080200_bib21","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1093\/nar\/gky1188","article-title":"Activation of Haa1 and War1 transcription factors by differential binding of weak acid anions in Saccharomyces cerevisiae","volume":"47","author":"Kim","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2025100910271080200_bib22","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.3389\/fmicb.2018.03265","article-title":"Effect of acetic acid and lactic acid at low pH in growth and azole resistance of Candida albicans and Candida glabrata","volume":"9","author":"Lourenco","year":"2018","journal-title":"Front Microbiol"},{"key":"2025100910271080200_bib23","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1534\/genetics.110.125708","article-title":"The Yak1 protein kinase lies at the center of a regulatory cascade affecting adhesive growth and stress resistance in Saccharomyces cerevisiae","volume":"187","author":"Malcher","year":"2011","journal-title":"Genetics"},{"key":"2025100910271080200_bib24","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1089\/omi.2010.0048","article-title":"Genomic expression program involving the Haa1p-regulon in Saccharomyces cerevisiae response to acetic acid","volume":"14","author":"Mira","year":"2010","journal-title":"Omics"},{"key":"2025100910271080200_bib25","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1089\/omi.2010.0072","article-title":"Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae: a genome-wide view","volume":"14","author":"Mira","year":"2010","journal-title":"Omics"},{"key":"2025100910271080200_bib26","doi-asserted-by":"publisher","first-page":"D597","DOI":"10.1093\/nar\/gkw817","article-title":"The PathoYeastract database: an information system for the analysis of gene and genomic transcription regulation in pathogenic yeasts","volume":"45","author":"Monteiro","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2025100910271080200_bib27","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1086\/599120","article-title":"Expression of Candida glabrata adhesins after exposure to chemical preservatives","volume":"199","author":"Mundy","year":"2009","journal-title":"J Infect Dis"},{"key":"2025100910271080200_bib28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12864-016-3443-2","article-title":"The Zygosaccharomyces bailii transcription factor Haa1 is required for acetic acid and copper stress responses suggesting subfunctionalization of the ancestral bifunctional protein Haa1\/Cup2","volume":"18","author":"Palma","year":"2017","journal-title":"BMC Genomics"},{"key":"2025100910271080200_bib29","doi-asserted-by":"publisher","first-page":"127628","DOI":"10.1016\/j.micres.2024.127628","article-title":"A molecular view on the interference established between vaginal lactobacilli and pathogenic Candida species: challenges and opportunities for the development of new therapies","volume":"281","author":"Pedro","year":"2024","journal-title":"Microbiol Res"},{"key":"2025100910271080200_bib30","doi-asserted-by":"publisher","first-page":"e1002863","DOI":"10.1371\/journal.ppat.1002863","article-title":"Functional genomic analysis of Candida glabrata-macrophage interaction: role of chromatin remodeling in virulence","volume":"8","author":"Rai","year":"2012","journal-title":"PLoS Pathog"},{"key":"2025100910271080200_bib31","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/j.1365-2958.2008.06301.x","article-title":"Candida glabrata environmental stress response involves Saccharomyces cerevisiae Msn2\/4 orthologous transcription factors","volume":"69","author":"Roetzer","year":"2008","journal-title":"Mol Microbiol"},{"key":"2025100910271080200_bib32","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/jof6010023","article-title":"An overview on conventional and non-conventional therapeutic approaches for the treatment of candidiasis and underlying resistance mechanisms in clinical strains","volume":"6","author":"Salazar","year":"2020","journal-title":"J Fungi (Basel)"},{"key":"2025100910271080200_bib43_934_070225","doi-asserted-by":"crossref","first-page":"e1004211","DOI":"10.1371\/journal.ppat.1004211","article-title":"Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes","volume":"10","author":"Schwarzm\u00fcller","year":"2014","journal-title":"PLoS Pathog"},{"key":"2025100910271080200_bib33","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.4049\/jimmunol.1003730","article-title":"The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation","volume":"187","author":"Seider","year":"2011","journal-title":"J Immunol"},{"key":"2025100910271080200_bib34","doi-asserted-by":"publisher","first-page":"3488","DOI":"10.1128\/AEM.04241-13","article-title":"Nuclear localization of Haa1, which is linked to its phosphorylation status, mediates lactic acid tolerance in Saccharomyces cerevisiae","volume":"80","author":"Sugiyama","year":"2014","journal-title":"Appl Environ Microb"},{"key":"2025100910271080200_bib35","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/jof4020060","article-title":"Adhesins in Candida glabrata","volume":"4","author":"Timmermans","year":"2018","journal-title":"J Fungi (Basel)"},{"key":"2025100910271080200_bib36","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/S0022-1910(99)00223-1","article-title":"Involvement of both granular cells and plasmatocytes in phagocytic reactions in the greater wax moth, Galleria mellonella","volume":"46","author":"Tojo","year":"2000","journal-title":"J Insect Physiol"},{"key":"2025100910271080200_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/jof5010003","article-title":"Immune response of Galleria mellonella against Human fungal pathogens","volume":"5","author":"Trevijano-Contador","year":"2018","journal-title":"J Fungi (Basel)"},{"key":"2025100910271080200_bib38","doi-asserted-by":"publisher","first-page":"e24759","DOI":"10.1371\/journal.pone.0024759","article-title":"Intestinal resident yeast Candida glabrata requires Cyb2p-mediated lactate assimilation to adapt in mouse intestine","volume":"6","author":"Ueno","year":"2011","journal-title":"PLoS One"},{"key":"2025100910271080200_bib39","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1128\/EC.00414-06","article-title":"Development of a highly efficient gene targeting system induced by transient repression of YKU80 expression in Candida glabrata","volume":"6","author":"Ueno","year":"2007","journal-title":"Euk Cell"},{"key":"2025100910271080200_bib40","doi-asserted-by":"publisher","first-page":"e00065","DOI":"10.1128\/mSphere.00065-15","article-title":"Upregulation of the Adhesin gene EPA1 mediated by PDR1 in Candida glabrata leads to enhanced host colonization","volume":"1","author":"Vale-Silva","year":"2016","journal-title":"mSphere"},{"key":"2025100910271080200_bib41","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1099\/mic.0.27256-0","article-title":"Systematic identification in silico of covalently bound cell wall proteins and analysis of protein-polysaccharide linkages of the human pathogen Candida glabrata","volume":"150","author":"Weig","year":"2004","journal-title":"Microbiology"},{"key":"2025100910271080200_bib42","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1111\/mmi.14488","article-title":"De novo genome assembly of Candida glabrata reveals cell wall protein complement and structure of dispersed tandem repeat arrays","volume":"113","author":"Xu","year":"2020","journal-title":"Mol Microbiol"}],"container-title":["FEMS Yeast Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/femsyr\/advance-article-pdf\/doi\/10.1093\/femsyr\/foaf054\/64313973\/foaf054.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsyr\/article-pdf\/doi\/10.1093\/femsyr\/foaf054\/64313973\/foaf054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsyr\/article-pdf\/doi\/10.1093\/femsyr\/foaf054\/64313973\/foaf054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T14:27:21Z","timestamp":1760020041000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsyr\/article\/doi\/10.1093\/femsyr\/foaf054\/8257570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":43,"URL":"https:\/\/doi.org\/10.1093\/femsyr\/foaf054","relation":{},"ISSN":["1567-1364"],"issn-type":[{"type":"electronic","value":"1567-1364"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2025]]},"article-number":"foaf054"}}