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Among the vast number of synthetic cannabinoids, designed to be tested in clinical trials, JWH-018 was the first novel psychoactive substance found in the recreational drug marketplace. The consumption of JWH-018 shows typical effects of CB1 agonists including sedation, cognitive dysfunction, tachycardia, postural hypotension, dry mouth, ataxia and psychotropic effects, but appeared to be more potent than \u03949-THC. However, studies on human cells have shown that JWH-018 toxicity depends on the cellular line used. Despite these studies, the underlying molecular mechanisms to JWH-018 action has not been clarified yet. To understand the impact of JWH-018 at molecular and cellular level, we used Saccharomyces cerevisiae as a model. The results showed an increase in yeast growth rate in the presence of this synthetic cannabinoid due to an enhancement in the glycolytic flux at expense of a decrease in pentose phosphate pathway, judging by 2D-Gel proteomic analysis, qRT-PCR experiments and ATP measurements. Overall, our results provide insights into molecular mechanisms of JWH-018 action, also indicating that Saccharomyces cerevisiae is a good model to study synthetic cannabinoids.<\/jats:p>","DOI":"10.1093\/femsyr\/foz042","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T03:14:00Z","timestamp":1560914040000},"source":"Crossref","is-referenced-by-count":3,"title":["The synthetic cannabinoid JWH-018 modulates <i>Saccharomyces cerevisiae<\/i> energetic metabolism"],"prefix":"10.1093","volume":"19","author":[{"given":"Carla","family":"Ferreira","sequence":"first","affiliation":[{"name":"Molecular Pathology and Forensic Biochemistry Laboratory, Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, P-2825-084 Caparica, Portugal"},{"name":"Laborat\u00f3rio de Ci\u00eancias Forenses e Psicol\u00f3gicas Egas Moniz, Campus Universit\u00e1rio \u2013 Quinta da Granja, Monte de Caparica, P-2825-084 Caparica, Portugal"},{"name":"Faculty of Medicine of Porto University, Al. Prof. Hern\u00e2ni Monteiro, P-4200\u2013319 Porto, Portugal"}]},{"given":"Joana","family":"Couceiro","sequence":"additional","affiliation":[{"name":"Molecular Pathology and Forensic Biochemistry Laboratory, Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, P-2825-084 Caparica, Portugal"},{"name":"Laborat\u00f3rio de Ci\u00eancias Forenses e Psicol\u00f3gicas Egas Moniz, Campus Universit\u00e1rio \u2013 Quinta da Granja, Monte de Caparica, P-2825-084 Caparica, Portugal"}]},{"given":"Carlos","family":"Fam\u00edlia","sequence":"additional","affiliation":[{"name":"Molecular Pathology and Forensic Biochemistry Laboratory, Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, P-2825-084 Caparica, Portugal"},{"name":"Laborat\u00f3rio de Ci\u00eancias Forenses e Psicol\u00f3gicas Egas Moniz, Campus Universit\u00e1rio \u2013 Quinta da Granja, Monte de Caparica, P-2825-084 Caparica, Portugal"}]},{"given":"Carolina","family":"Jardim","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, P-2780\u2013901 Oeiras, Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica, Universidade Nova de Lisboa, Av. da Rep\u00fablica, P-2780-157 Oeiras, Portugal"}]},{"given":"Pedro","family":"Antas","sequence":"additional","affiliation":[{"name":"CEDOC \u2013 Chronic Diseases Research Center, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, P-1150-082 Lisboa, Portugal"}]},{"given":"Cl\u00e1udia N","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, P-2780\u2013901 Oeiras, Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica, Universidade Nova de Lisboa, Av. da Rep\u00fablica, P-2780-157 Oeiras, Portugal"},{"name":"CEDOC \u2013 Chronic Diseases Research Center, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, P-1150-082 Lisboa, Portugal"}]},{"given":"Tiago F","family":"Outeiro","sequence":"additional","affiliation":[{"name":"CEDOC \u2013 Chronic Diseases Research Center, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, P-1150-082 Lisboa, Portugal"},{"name":"Department of Experimental Neurodegeneration, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center G\u00f6ttingen, Waldweg 33. 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