{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:39:42Z","timestamp":1773790782862,"version":"3.50.1"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Germline mutations are the ultimate source of genetic variation and the raw material for organismal evolution. Despite their significance, the frequency and genomic locations of mutations, as well as potential sex bias, are yet to be widely investigated in most species. To address these gaps, we conducted whole-genome sequencing of 12 great reed warblers (Acrocephalus arundinaceus) in a pedigree spanning 3 generations to identify single-nucleotide de novo mutations (DNMs) and estimate the germline mutation rate. We detected 82 DNMs within the pedigree, primarily enriched at CpG sites but otherwise randomly located along the chromosomes. Furthermore, we observed a pronounced sex bias in DNM occurrence, with male warblers exhibiting three times more mutations than females. After correction for false negatives and adjusting for callable sites, we obtained a mutation rate of 7.16 \u00d7 10\u22129 mutations per site per generation (m\/s\/g) for the autosomes and 5.10 \u00d7 10\u22129\u2005m\/s\/g for the Z chromosome. To demonstrate the utility of species-specific mutation rates, we applied our autosomal mutation rate in models reconstructing the demographic history of the great reed warbler. We uncovered signs of drastic population size reductions predating the last glacial period (LGP) and reduced gene flow between western and eastern populations during the LGP. In conclusion, our results provide one of the few direct estimates of the mutation rate in wild songbirds and evidence for male-driven mutations in accordance with theoretical expectations.<\/jats:p>","DOI":"10.1093\/gbe\/evad180","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:10:00Z","timestamp":1696349400000},"source":"Crossref","is-referenced-by-count":5,"title":["Evidence of Site-Specific and Male-Biased Germline Mutation Rate in a Wild Songbird"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7371-9612","authenticated-orcid":false,"given":"Hongkai","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biology, Lund University , Lund , Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1895-3622","authenticated-orcid":false,"given":"Max","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Department of Biology, Lund University , Lund , Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-1101","authenticated-orcid":false,"given":"Maja","family":"Tarka","sequence":"additional","affiliation":[{"name":"Department of Biology, Lund University , Lund , Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0056-6616","authenticated-orcid":false,"given":"Dennis","family":"Hasselquist","sequence":"additional","affiliation":[{"name":"Department of Biology, Lund University , Lund , Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6694-8169","authenticated-orcid":false,"given":"Bengt","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Biology, Lund University , Lund , Sweden"}]}],"member":"286","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"2023110617300132700_evad180-B1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search 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