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In Caenorhabditis elegans, these dynein functions have been extensively studied in the early embryo but remain poorly explored in other developmental contexts. Here, we use a hypomorphic dynein mutant to investigate the motor's contribution to asymmetric stem cell\u2013like divisions in the larval epidermis. Live imaging of seam cell divisions that precede formation of the seam syncytium shows that mutant cells properly assemble but frequently misorient their spindle. Misoriented divisions misplace daughter cells from the seam cell row, generate anucleate compartments due to aberrant cytokinesis, and disrupt asymmetric cell fate inheritance. Consequently, the seam becomes disorganized and populated with extra cells that have lost seam identity, leading to fatal epidermal rupture. We show that dynein orients the spindle through the cortical GOA-1G\u03b1\u2013LIN-5NuMA pathway by directing the migration of prophase centrosomes along the anterior\u2013posterior axis. Spindle misorientation in the dynein mutant can be partially rescued by elongating cells, implying that dynein-dependent force generation and cell shape jointly promote correct asymmetric division of epithelial stem cells.<\/jats:p>","DOI":"10.1093\/genetics\/iyae005","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T07:19:36Z","timestamp":1705043976000},"source":"Crossref","is-referenced-by-count":0,"title":["Dynein directs prophase centrosome migration to control the stem cell division axis in the developing <i>Caenorhabditis elegans<\/i> epidermis"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-7445","authenticated-orcid":false,"given":"C\u00e1tia","family":"Carvalho","sequence":"first","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , Porto 4200-135 ,","place":["Portugal"]},{"name":"IBMC\u2014Instituto de Biologia Molecular e Celular, Universidade do Porto , Porto 4200-135 ,","place":["Portugal"]},{"name":"ICBAS\u2014Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto , Porto 4050-313 ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1726-6011","authenticated-orcid":false,"given":"Daniel J","family":"Barbosa","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , Porto 4200-135 ,","place":["Portugal"]},{"name":"IBMC\u2014Instituto de Biologia Molecular e Celular, Universidade do Porto , Porto 4200-135 ,","place":["Portugal"]},{"name":"1H-Toxrun\u2014One Health Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL , Gandra 4585-116 ,","place":["Portugal"]}]},{"given":"Ricardo","family":"Celestino","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , Porto 4200-135 ,","place":["Portugal"]},{"name":"IBMC\u2014Instituto de Biologia Molecular e Celular, Universidade do Porto , Porto 4200-135 ,","place":["Portugal"]}]},{"given":"Esther","family":"Zanin","sequence":"additional","affiliation":[{"name":"Department Biologie, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg , Erlangen 91058 ,","place":["Germany"]}]},{"given":"Ana","family":"Xavier Carvalho","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , Porto 4200-135 ,","place":["Portugal"]},{"name":"IBMC\u2014Instituto de Biologia Molecular e Celular, Universidade do Porto , Porto 4200-135 ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-2977","authenticated-orcid":false,"given":"Reto","family":"Gassmann","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, 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