{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:00:33Z","timestamp":1790236833660,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Sichuan Science and Technology Program","award":["2024NSFSC0050"],"award-info":[{"award-number":["2024NSFSC0050"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFC3600600"],"award-info":[{"award-number":["2022YFC3600600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Telomere length (TL) is a well-established biomarker of cellular senescence, yet the metabolic profile of TL and its associations with aging-related phenotypes and responses to modifiable lifestyle factors remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TL was measured using quantitative real-time polymerase chain reaction (qPCR) in 282 participants from the West China Health and Aging Cohort (WCHAC). Plasma metabolites were analyzed using liquid chromatography-tandem mass spectrometry. TL-associated metabolic signatures (Met-TL) were identified through elastic net regression models. Associations between Met-TL and aging-related phenotypes and modifiable lifestyle factors were evaluated using linear and logistic regression models in a larger, non-overlapping sample of 5957 WCHAC participants. Furthermore, we employed mediation analysis to explore the mediating effects of Met-TL between lifestyle factors and aging-related diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified a plasma metabolite signature comprising 26 metabolites explaining 17.5% of TL variance. Met-TL significantly associated with aging-related phenotypes (44 Bonferroni-corrected associations) and modifiable lifestyle factors (4 associations). Notably, Met-TL showed robust associations with steatohepatitis and hepatic biomarkers. Mediation analysis revealed that Met-TL partially explained the protective association between healthy lifestyle and steatohepatitis, with a mediation proportion of 8.2%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings provide novel insights into the metabolic profile of TL in older adults. The Met-TL may serve as a promising biomarker of cellular aging, particularly in identifying liver dysfunction, facilitating the development of personalized aging monitoring and anti-aging intervention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gerona\/glag209","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:12:34Z","timestamp":1787926354000},"source":"Crossref","is-referenced-by-count":0,"title":["Metabolomic profiling of telomere length: associations with aging-related phenotypes and modifiable lifestyle factors in Chinese older adults"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4510-9697","authenticated-orcid":false,"given":"Tianpei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University , 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