{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:17:15Z","timestamp":1772687835766,"version":"3.50.1"},"reference-count":100,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T00:00:00Z","timestamp":1575676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG054538"],"award-info":[{"award-number":["R01AG054538"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Declining cognitive functions in older individuals have enormous emotional, clinical, and public health consequences. Thus, therapeutics for preserving function and keeping older adults living independently are imperative. Aging is associated dysbiosis, defined as a loss of number and diversity in gut microbiota, which has been linked with various aspects of cognitive functions. Therefore, the gut microbiome has the potential to be an important therapeutic target for symptoms of cognitive impairment. In this review, we summarize the current literature regarding the potential for gut-targeted therapeutic strategies for prevention\/treatment of the symptoms of cognitive impairment. Specifically, we discuss four primary therapeutic strategies: wild-type and genetically modified probiotics, fecal microbiota transplantation, physical exercise, and high-fiber diets and specifically link these therapies to reducing inflammation. These strategies may hold promise as treatment paradigm symptoms related to cognitive impairment.<\/jats:p>","DOI":"10.1093\/gerona\/glz281","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T07:43:10Z","timestamp":1575704590000},"page":"1242-1250","source":"Crossref","is-referenced-by-count":63,"title":["The Gut Microbiome as a Therapeutic Target for Cognitive Impairment"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3307-3471","authenticated-orcid":false,"given":"Yi","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Care, School of Medicine"},{"name":"Integrative Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, Alabama"}]},{"given":"Liliana C","family":"Baptista","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Care, School of Medicine"},{"name":"Integrative Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, Alabama"}]},{"given":"Lisa M","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Care, School of Medicine"},{"name":"Integrative Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, Alabama"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9329-0873","authenticated-orcid":false,"given":"Patricia","family":"Jumbo-Lucioni","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical, Social and Administrative Sciences, McWhorter School of Pharmacy, Samford University, Homewood, Alabama"}]},{"given":"Lori L","family":"McMahon","sequence":"first","affiliation":[{"name":"Integrative Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, Alabama"},{"name":"Department of Cell, Developmental, and Integrative Biology, School of Medicine"},{"name":"Comprehensive Neuroscience Center, University of Alabama at Birmingham, Birmingham, Alabama"}]},{"given":"Thomas W","family":"Buford","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Care, School of Medicine"},{"name":"Integrative Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, Alabama"}]},{"given":"Christy S","family":"Carter","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gerontology, Geriatrics and Palliative Care, School of Medicine"},{"name":"Integrative Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, Alabama"}]}],"member":"286","published-online":{"date-parts":[[2019,12,7]]},"reference":[{"key":"2020061812135066300_CIT0001","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3233\/JAD-170963","article-title":"Different cognitive frailty models and health- and cognitive-related outcomes in older age: 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