{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:21:52Z","timestamp":1776709312587,"version":"3.51.2"},"reference-count":336,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":149,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CA19144"],"award-info":[{"award-number":["CA19144"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["271522021"],"award-info":[{"award-number":["271522021"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["413120531"],"award-info":[{"award-number":["413120531"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["7017-00288"],"award-info":[{"award-number":["7017-00288"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Venoms have evolved &amp;gt;100 times in all major animal groups, and their components, known as toxins, have been fine-tuned over millions of years into highly effective biochemical weapons. There are many outstanding questions on the evolution of toxin arsenals, such as how venom genes originate, how venom contributes to the fitness of venomous species, and which modifications at the genomic, transcriptomic, and protein level drive their evolution. These questions have received particularly little attention outside of snakes, cone snails, spiders, and scorpions. Venom compounds have further become a source of inspiration for translational research using their diverse bioactivities for various applications. We highlight here recent advances and new strategies in modern venomics and discuss how recent technological innovations and multi-omic methods dramatically improve research on venomous animals. The study of genomes and their modifications through CRISPR and knockdown technologies will increase our understanding of how toxins evolve and which functions they have in the different ontogenetic stages during the development of venomous animals. Mass spectrometry imaging combined with spatial transcriptomics, in situ hybridization techniques, and modern computer tomography gives us further insights into the spatial distribution of toxins in the venom system and the function of the venom apparatus. All these evolutionary and biological insights contribute to more efficiently identify venom compounds, which can then be synthesized or produced in adapted expression systems to test their bioactivity. Finally, we critically discuss recent agrochemical, pharmaceutical, therapeutic, and diagnostic (so-called translational) aspects of venoms from which humans benefit.<\/jats:p>","DOI":"10.1093\/gigascience\/giac048","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T11:33:38Z","timestamp":1728992018000},"source":"Crossref","is-referenced-by-count":81,"title":["Modern venomics\u2014Current insights, novel methods, and future perspectives in biological and applied animal venom research"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7462-8226","authenticated-orcid":false,"given":"Bjoern M","family":"von\u00a0Reumont","sequence":"first","affiliation":[{"name":"Goethe University Frankfurt, Institute for Cell Biology and Neuroscience, Department for Applied Bioinformatics , 60438 Frankfurt am Main,","place":["Germany"]},{"name":"LOEWE Centre for Translational Biodiversity Genomics, Senckenberg Frankfurt , Senckenberganlage 25, 60235 Frankfurt,","place":["Germany"]},{"name":"Justus Liebig University Giessen, Institute for Insectbiotechnology , Heinrich Buff Ring 26-32, 35396 Giessen,","place":["Germany"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-8465","authenticated-orcid":false,"given":"Gregor","family":"Anderluh","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry , 1000 Ljubljana,","place":["Slovenia"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1328-1732","authenticated-orcid":false,"given":"Agostinho","family":"Antunes","sequence":"additional","affiliation":[{"name":"CIIMAR\/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto de Leix\u00f5es , Av. General Norton de Matos, s\/n, 4450\u2013208 Porto,","place":["Portugal"]},{"name":"Department of Biology, Faculty of Sciences, University of Porto , Rua do Campo Alegre, 4169-007 Porto,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7588-2277","authenticated-orcid":false,"given":"Naira","family":"Ayvazyan","sequence":"additional","affiliation":[{"name":"Orbeli Institute of Physiology of NAS RA , Orbeli ave. 22, 0028 Yerevan,","place":["Armenia"]}]},{"given":"Dimitris","family":"Beis","sequence":"additional","affiliation":[{"name":"Developmental Biology, Centre for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens , Athens 11527,","place":["Greece"]}]},{"given":"Figen","family":"Caliskan","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science and Letters, Eskisehir Osmangazi University , TR-26040 Eskisehir,","place":["Turkey"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-1887","authenticated-orcid":false,"given":"Ana","family":"Crnkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry , 1000 Ljubljana,","place":["Slovenia"]}]},{"given":"Maik","family":"Damm","sequence":"additional","affiliation":[{"name":"Technische Universit\u00e4t Berlin, Department of Chemistry , Stra\u00dfe des 17. Juni 135, 10623 Berlin,","place":["Germany"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-1484","authenticated-orcid":false,"given":"Sebastien","family":"Dutertre","sequence":"additional","affiliation":[{"name":"IBMM, Univ Montpellier, CNRS, ENSCM , 34095 Montpellier,","place":["France"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-0137","authenticated-orcid":false,"given":"Lars","family":"Ellgaard","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Copenhagen , DK-2200 Copenhagen,","place":["Denmark"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-1453","authenticated-orcid":false,"given":"Goran","family":"Gajski","sequence":"additional","affiliation":[{"name":"Institute for Medical Research and Occupational Health, Mutagenesis Unit , Ksaverska cesta 2, 10000 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