{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:35:58Z","timestamp":1762673758494},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1093\/glycob\/cwq020","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:18:47Z","timestamp":1267057127000},"page":"812-823","source":"Crossref","is-referenced-by-count":69,"title":["Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans"],"prefix":"10.1093","volume":"20","author":[{"given":"D Cameron","family":"Dunlop","sequence":"first","affiliation":[]},{"given":"Camille","family":"Bonomelli","sequence":"additional","affiliation":[]},{"given":"Fatma","family":"Mansab","sequence":"additional","affiliation":[]},{"given":"Snezana","family":"Vasiljevic","sequence":"additional","affiliation":[]},{"given":"Katie J","family":"Doores","sequence":"additional","affiliation":[]},{"given":"Mark R","family":"Wormald","sequence":"additional","affiliation":[]},{"given":"Angelina S","family":"Palma","sequence":"additional","affiliation":[]},{"given":"Ten","family":"Feizi","sequence":"additional","affiliation":[]},{"given":"David J","family":"Harvey","sequence":"additional","affiliation":[]},{"given":"Raymond A","family":"Dwek","sequence":"additional","affiliation":[]},{"given":"Max","family":"Crispin","sequence":"additional","affiliation":[]},{"given":"Christopher N","family":"Scanlan","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"key\n\t\t\t\t20170508192700_ref1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1107\/S0907444906029799","article-title":"A time- and cost-efficient system for high-level protein production in mammalian cells","volume":"62","author":"Aricescu","year":"2006","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"key\n\t\t\t\t20170508192700_ref2","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1128\/JVI.00293-08","article-title":"A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120","volume":"82","author":"Astronomo","year":"2008","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170508192700_ref3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0076-6879(90)85038-P","article-title":"Isolation, characterization, and properties of Saccharomyces cerevisiae mnn mutants with nonconditional protein glycosylation defects","volume":"185","author":"Ballou","year":"1990","journal-title":"Methods Enzymol"},{"key":"key\n\t\t\t\t20170508192700_ref4","doi-asserted-by":"crossref","first-page":"17033","DOI":"10.1073\/pnas.0407902101","article-title":"Printed covalent glycan array for ligand profiling of diverse glycan binding proteins","volume":"101","author":"Blixt","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170508192700_ref5","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/rcm.1290091112","article-title":"Ion exchange and purification of carbohydrates on a Nafion(r) membrane as a new sample pretreatment for matrix- assisted laser desorption-ionization mass spectrometry","volume":"9","author":"B\u00f6rnsen","year":"1995","journal-title":"Rapid Commun Mass Spectrom"},{"key":"key\n\t\t\t\t20170508192700_ref7","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1128\/JVI.00761-09","article-title":"Unusual molecular architecture of the machupo virus attachment glycoprotein","volume":"83","author":"Bowden","year":"2009","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170508192700_ref6","doi-asserted-by":"crossref","first-page":"11628","DOI":"10.1128\/JVI.01344-08","article-title":"Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: A template for antiviral and vaccine design","volume":"82","author":"Bowden","year":"2008","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170508192700_ref8","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/nri891","article-title":"Antibodies, viruses and vaccines","volume":"2","author":"Burton","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20170508192700_ref9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ni0304-233","article-title":"HIV vaccine design and the neutralizing antibody problem","volume":"5","author":"Burton","year":"2004","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20170508192700_ref10","doi-asserted-by":"crossref","first-page":"14943","DOI":"10.1073\/pnas.0505126102","article-title":"Antibody vs. HIV in a clash of evolutionary titans","volume":"102","author":"Burton","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170508192700_ref12","doi-asserted-by":"crossref","first-page":"13372","DOI":"10.1073\/pnas.0505763102","article-title":"Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12","volume":"102","author":"Calarese","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170508192700_ref11","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1126\/science.1083182","article-title":"Antibody domain exchange is an immunological solution to carbohydrate cluster recognition","volume":"300","author":"Calarese","year":"2003","journal-title":"Science."},{"key":"key\n\t\t\t\t20170508192700_ref13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.str.2007.01.011","article-title":"Glycoprotein structural genomics: Solving the glycosylation problem","volume":"15","author":"Chang","year":"2007","journal-title":"Structure"},{"key":"key\n\t\t\t\t20170508192700_ref14","doi-asserted-by":"crossref","first-page":"21684","DOI":"10.1074\/jbc.M109.006254","article-title":"A human embryonic kidney 293T cell line mutated at the Golgi \u03b1-mannosidase II locus","volume":"284","author":"Crispin","year":"2009","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170508192700_ref15","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/glycob\/cwj119","article-title":"Inhibition of hybrid- and complex-type glycosylation reveals the presence of the GlcNAc transferase I-independent fucosylation pathway","volume":"16","author":"Crispin","year":"2006","journal-title":"Glycobiology"},{"key":"key\n\t\t\t\t20170508192700_ref16","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.jasms.2004.07.008","article-title":"Characterization of glycopeptides from HIV-I(SF2) gp120 by liquid chromatography mass spectrometry","volume":"15","author":"Cutalo","year":"2004","journal-title":"J Am Soc Mass Spectrom"},{"key":"key\n\t\t\t\t20170508192700_ref17","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1128\/JVI.00093-06","article-title":"Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: Evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses","volume":"80","author":"Deeks","year":"2006","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170508192700_ref18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF01049915","article-title":"A systematic nomenclature for carbohydrate fragmentations in FAB-MS\/MS spectra of glycoconjugates","volume":"5","author":"Domon","year":"1988","journal-title":"Glycoconjugate J"},{"key":"key\n\t\t\t\t20170508192700_ref19","doi-asserted-by":"crossref","first-page":"9560","DOI":"10.1021\/ja047720g","article-title":"Toward fully synthetic carbohydrate-based HIV antigen design: On the critical role of bivalency","volume":"126","author":"Dudkin","year":"2004","journal-title":"J Am Chem Soc"},{"key":"key\n\t\t\t\t20170508192700_ref20","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1097\/QAD.0b013e328314b5df","article-title":"Antigenic mimicry of the HIV envelope by AIDS-associated pathogens","volume":"22","author":"Dunlop","year":"2008","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20170508192700_ref21","doi-asserted-by":"crossref","first-page":"18514","DOI":"10.1073\/pnas.0504658102","article-title":"Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection","volume":"102","author":"Frost","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170508192700_ref23","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1432-1033.1990.tb19409.x","article-title":"Glycosylation of the envelope glycoprotein from a polytropic murine retrovirus in two different host cells","volume":"193","author":"Geyer","year":"1990","journal-title":"Eur J Biochem"},{"key":"key\n\t\t\t\t20170508192700_ref24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-4615-1823-5_8","article-title":"Adjuvant properties of aluminum and calcium compounds","volume":"6","author":"Gupta","year":"1995","journal-title":"Pharm Biotechnol"},{"key":"key\n\t\t\t\t20170508192700_ref25","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jasms.2005.01.004","article-title":"Fragmentation of negative ions from carbohydrates: Part 1. Use of nitrate and other anionic adducts for the production of negative ion electrospray spectra from N-linked carbohydrates","volume":"16","author":"Harvey","year":"2005","journal-title":"J Am Soc Mass Spectrom"},{"key":"key\n\t\t\t\t20170508192700_ref26","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jasms.2005.01.005","article-title":"Fragmentation of negative ions from carbohydrates: Part 2. Fragmentation of high-mannose N-linked glycans","volume":"16","author":"Harvey","year":"2005","journal-title":"J Am Soc Mass Spectrom"},{"key":"key\n\t\t\t\t20170508192700_ref27","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jasms.2005.01.006","article-title":"Fragmentation of negative ions from carbohydrates: Part 3. Fragmentation of hybrid and complex N-linked glycans","volume":"16","author":"Harvey","year":"2005","journal-title":"J Am Soc Mass Spectrom"},{"key":"key\n\t\t\t\t20170508192700_ref28","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/pmic.200401248","article-title":"Structural determination of N-linked glycans by matrix-assisted laser desorption\/ionization and electrospray ionization mass spectrometry","volume":"5","author":"Harvey","year":"2005","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20170508192700_ref30","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1002\/pmic.200900096","article-title":"Proposal for a standard system for drawing structural diagrams of N- and O-linked carbohydrates and related compounds","volume":"9","author":"Harvey","year":"2009","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20170508192700_ref29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ab.2008.01.025","article-title":"Structural and quantitative analysis of N-linked glycans by matrix-assisted laser desorption ionization and negative ion nanospray mass spectrometry","volume":"376","author":"Harvey","year":"2008","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20170508192700_ref31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/nm.1974","article-title":"Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques","volume":"15","author":"Hessell","year":"2009","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170508192700_ref32","doi-asserted-by":"crossref","first-page":"e1000433","DOI":"10.1371\/journal.ppat.1000433","article-title":"Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers","volume":"5","author":"Hessell","year":"2009","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20170508192700_ref33","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1006\/abio.1997.2199","article-title":"Sequencing of N-linked oligosaccharides directly from protein gels: In-gel deglycosylation followed by matrix-assisted laser desorption\/ionization mass spectrometry and normal-phase high-performance liquid chromatography","volume":"250","author":"K\u00fcster","year":"1997","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20170508192700_ref34","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/anie.200353105","article-title":"Reactivity-based one-pot synthesis of oligomannoses: Defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody","volume":"43","author":"Lee","year":"2004","journal-title":"Angew Chem Int Ed Engl"},{"key":"key\n\t\t\t\t20170508192700_ref35","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1128\/JVI.00412-08","article-title":"An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing human immunodeficiency virus type 1 antibody 2G12 and elicits mannose-specific gp120-binding antibodies","volume":"82","author":"Luallen","year":"2008","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170508192700_ref36","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/72318","article-title":"Protection of macaques against vaginal transmission of a pathogenic HIV-1\/SIV chimeric virus by passive infusion of neutralizing antibodies","volume":"6","author":"Mascola","year":"2000","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170508192700_ref37","first-page":"694","article-title":"Antibodies against defined carbohydrate structures of Candida albicans protect H9 cells against infection with human immunodeficiency virus-1 in vitro","volume":"4","author":"Muller","year":"1991","journal-title":"J Acquir Immune Defic Syndr"},{"key":"key\n\t\t\t\t20170508192700_ref55","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1074\/jbc.M511461200","article-title":"Ligands for the beta-glucan receptor, Dectin-1, assigned using \u2018designer' microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides","volume":"281","author":"Palma","year":"2006","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170508192700_ref38","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.immunol.24.021605.090557","article-title":"GP120: Target for neutralizing HIV-1 antibodies","volume":"24","author":"Pantophlet","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20170508192700_ref39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0165-2478(97)00043-6","article-title":"Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design","volume":"57","author":"Parren","year":"1997","journal-title":"Immunol Lett"},{"key":"key\n\t\t\t\t20170508192700_ref40","first-page":"S137","article-title":"The neutralizing antibody response to HIV-1: Viral evasion and escape from humoral immunity","volume-title":"Aids","author":"Parren","year":"1999"},{"key":"key\n\t\t\t\t20170508192700_ref41","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/glycob\/9.4.343","article-title":"A statistical analysis of N- and O-glycan linkage conformations from crystallographic data","volume":"9","author":"Petrescu","year":"1999","journal-title":"Glycobiology"},{"key":"key\n\t\t\t\t20170508192700_ref42","doi-asserted-by":"crossref","first-page":"13419","DOI":"10.1073\/pnas.212519299","article-title":"Structure and function in rhodopsin: High-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line","volume":"99","author":"Reeves","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170508192700_ref43","doi-asserted-by":"crossref","first-page":"7293","DOI":"10.1128\/JVI.76.14.7293-7305.2002","article-title":"The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120","volume":"76","author":"Sanders","year":"2002","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170508192700_ref45","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/nature05818","article-title":"Exploiting the defensive sugars of HIV-1 for drug and vaccine design","volume":"446","author":"Scanlan","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170508192700_ref44","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1128\/JVI.76.14.7306-7321.2002","article-title":"The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of \u03b11\u21922mannose residues on the outer face of gp120","volume":"76","author":"Scanlan","year":"2002","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170508192700_ref46","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jmb.2007.06.027","article-title":"Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody","volume":"372","author":"Scanlan","year":"2007","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20170508192700_ref47","doi-asserted-by":"crossref","first-page":"7337","DOI":"10.1128\/JVI.00110-09","article-title":"Human immunodeficiency virus type 1 elite neutralizers: Individuals with broad and potent neutralizing activity identified by using a high- throughput neutralization assay together with an analytical selection algorithm","volume":"83","author":"Simek","year":"2009","journal-title":"J Virol"},{"key":"key\n\t\t\t\t20170508192700_ref48","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0006-291X(91)91979-M","article-title":"Recognition of human immunodeficiency virus glycoproteins by natural anti-carbohydrate antibodies in human serum","volume":"177","author":"Tomiyama","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170508192700_ref49","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1126\/science.1178746","article-title":"Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target","volume":"326","author":"Walker","year":"2009","journal-title":"Science"},{"key":"key\n\t\t\t\t20170508192700_ref50","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature01470","article-title":"Antibody neutralization and escape by HIV-1","volume":"422","author":"Wei","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170508192700_ref51","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1085-9489.2005.0010202.x","article-title":"The immunobiology of Guillain-Barre syndromes","volume":"10","author":"Willison","year":"2005","journal-title":"J Peripher Nerv Syst"},{"key":"key\n\t\t\t\t20170508192700_ref52","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1046\/j.1432-1327.1998.2580372.x","article-title":"The high degree of internal flexibility observed for an oligomannose oligosaccharide does not alter the overall topology of the molecule","volume":"258","author":"Woods","year":"1998","journal-title":"Eur J Biochem"},{"key":"key\n\t\t\t\t20170508192700_ref53","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1021\/cr990368i","article-title":"Conformational studies of oligosaccharides and glycopeptides: Complementarity of NMR, X-ray crystallography, and molecular modelling","volume":"102","author":"Wormald","year":"2002","journal-title":"Chem Rev"},{"key":"key\n\t\t\t\t20170508192700_ref54","doi-asserted-by":"crossref","first-page":"11194","DOI":"10.1021\/bi000432m","article-title":"Mass spectrometric characterization of the glycosylation pattern of HIV-gp120 expressed in CHO cells","volume":"39","author":"Zhu","year":"2000","journal-title":"Biochemistry"}],"container-title":["Glycobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/glycob\/article-pdf\/20\/7\/812\/16653688\/cwq020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T04:07:04Z","timestamp":1503547624000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/glycob\/article-lookup\/doi\/10.1093\/glycob\/cwq020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,24]]},"references-count":54,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2010,2,24]]},"published-print":{"date-parts":[[2010,7]]}},"URL":"https:\/\/doi.org\/10.1093\/glycob\/cwq020","relation":{},"ISSN":["1460-2423","0959-6658"],"issn-type":[{"value":"1460-2423","type":"electronic"},{"value":"0959-6658","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2,24]]}}}