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The high proliferative and invasive nature of GB, as well as its acquired resistance to chemotherapy, makes this type of cancer extremely lethal shortly after diagnosis. Long non-protein coding RNAs (lncRNA) are a class of regulatory RNAs whose levels can be dysregulated in the context of diseases, unbalancing several physiological processes. The lncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA-MVIH), overexpressed in several cancers, was described to co-precipitate with phosphoglycerate kinase 1 (PGK1), preventing secretion of this enzyme to the extracellular environment and promoting cell migration and invasion. We hypothesized that, by silencing the expression of lncRNA-MVIH, the secretion of PGK1 would increase, reducing GB cell migration and invasion capabilities. We observed that lncRNA-MVIH silencing in human GB cells significantly decreased glycolysis, cell growth, migration, and invasion and sensitized GB cells to cediranib. However, no increase in extracellular PGK1 was observed as a consequence of lncRNA-MVIH silencing, and therefore, we investigated the possibility of a mechanism of miRNA sponge of lncRNA-MVIH being in place. We found that the levels of miR-302a loaded onto RISC increased in GB cells after lncRNA-MVIH silencing, with the consequent downregulation of several miR-302a molecular targets. Our findings suggest a new mechanism of action of lncRNA-MVIH as a sponge of miR-302a. We suggest that lncRNA-MVIH knockdown may be a promising strategy to address GB invasiveness and chemoresistance, holding potential towards its future application in a clinical context.<\/jats:p>","DOI":"10.1093\/hmg\/ddab009","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T12:22:14Z","timestamp":1610108534000},"page":"46-64","source":"Crossref","is-referenced-by-count":9,"title":["Downregulation of long non-protein coding RNA MVIH impairs glioblastoma cell proliferation and invasion through an miR-302a-dependent mechanism"],"prefix":"10.1093","volume":"30","author":[{"given":"Ana M","family":"Cardoso","sequence":"first","affiliation":[{"name":"CNC \u2013 Center for Neuroscience and Cell Biology, CIBB \u2013 Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, IIIUC \u2013 Institute for Interdisciplinary Research, Coimbra, Portugal"}]},{"given":"Catarina M","family":"Morais","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"given":"Olinda","family":"Rebelo","sequence":"additional","affiliation":[{"name":"Neuropathology Laboratory, Neurology Service, University Hospital of Coimbra, 3004-561 Coimbra, Portugal"}]},{"given":"Herm\u00ednio","family":"T\u00e3o","sequence":"additional","affiliation":[{"name":"Neurosurgery Service, University Hospital of Coimbra, 33004-561 Coimbra, Portugal"}]},{"given":"Marcos","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Neurosurgery Service, University Hospital of Coimbra, 33004-561 Coimbra, Portugal"},{"name":"Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Maria C","family":"Pedroso de Lima","sequence":"additional","affiliation":[{"name":"CNC \u2013 Center for Neuroscience and Cell Biology, CIBB \u2013 Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, IIIUC \u2013 Institute for Interdisciplinary Research, Coimbra, Portugal"}]},{"given":"Am\u00e1lia S","family":"Jurado","sequence":"additional","affiliation":[{"name":"CNC \u2013 Center for Neuroscience and Cell Biology, CIBB \u2013 Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, IIIUC \u2013 Institute for Interdisciplinary Research, Coimbra, Portugal"},{"name":"Department of Life Sciences, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"issue":"6348","key":"2021040906161788200_ref1","doi-asserted-by":"crossref","first-page":"eaal2380","DOI":"10.1126\/science.aal2380","article-title":"Epigenetic plasticity and the hallmarks of cancer","volume":"357","author":"Flavahan","year":"2017","journal-title":"Science (New York, N.Y.)"},{"issue":"1","key":"2021040906161788200_ref2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.gpb.2015.09.006","article-title":"Roles, functions, and mechanisms of long non-coding RNAs in cancer","volume":"14","author":"Fang","year":"2016","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"2021040906161788200_ref3","doi-asserted-by":"crossref","first-page":"4723193","DOI":"10.1155\/2017\/4723193","article-title":"Molecular crosstalking among noncoding RNAs: A new network layer of genome regulation in cancer","volume":"2017","author":"Ragusa","year":"2017","journal-title":"Int J Genomics"},{"issue":"1","key":"2021040906161788200_ref4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng1285","article-title":"Complete sequencing and characterization of 21,243 full-length human cDNAs","volume":"36","author":"Ota","year":"2004","journal-title":"Nat. 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