{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:16:22Z","timestamp":1768896982583,"version":"3.49.0"},"reference-count":94,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":263,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Botrytis cinerea is responsible for the gray mold disease, severely affecting Vitis vinifera grapevine and hundreds of other economically important crops. However, many mechanisms of this fruit-pathogen interaction remain unknown. The combined analysis of the transcriptome and metabolome of green fruits infected with B. cinerea from susceptible and tolerant genotypes was never performed in any fleshy fruit, mostly because green fruits are widely accepted to be resistant to this fungus. In this work, peppercorn-sized fruits were infected in the field or mock-treated, and berries were collected at green (EL32) stage from a susceptible (Trincadeira) and a tolerant (Syrah) variety. RNAseq and GC\u2013MS data suggested that Syrah exhibited a pre-activated\/basal defense relying on specific signaling pathways, hormonal regulation, namely jasmonate and ethylene metabolisms, and linked to phenylpropanoid metabolism. In addition, putative defensive metabolites such as shikimic, ursolic\/ oleanolic, and trans-4-hydroxy cinnamic acids, and epigallocatechin were more abundant in Syrah than Trincadeira before infection. On the other hand, Trincadeira underwent relevant metabolic reprogramming upon infection but was unable to contain disease progression. RNA-seq analysis of the fungus in planta revealed an opposite scenario with higher gene expression activity within B. cinerea during infection of the tolerant cultivar and less activity in infected Trincadeira berries. The results suggested an activated virulence state during interaction with the tolerant cultivar without visible disease symptoms. Together, this study brings novel insights related to early infection strategies of B. cinerea and the green berry defense against necrotrophic fungi.<\/jats:p>","DOI":"10.1093\/hr\/uhac217","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T23:57:49Z","timestamp":1663804669000},"source":"Crossref","is-referenced-by-count":12,"title":["Virulence-related metabolism is activated in <i>Botrytis cinerea<\/i> mostly in the interaction with tolerant green grapes that remain largely unaffected in contrast with susceptible green grapes"],"prefix":"10.1093","volume":"9","author":[{"given":"Fl\u00e1vio","family":"Soares","sequence":"first","affiliation":[{"name":"University of Lisbon BioISI - Biosystems and Integrative Sciences Institute, Faculty of Sciences, , Campo Grande, 1749-016 Lisboa, Portugal"}]},{"given":"Diana","family":"Pimentel","sequence":"additional","affiliation":[{"name":"University of Lisbon BioISI - Biosystems and Integrative Sciences Institute, Faculty of Sciences, , Campo Grande, 1749-016 Lisboa, Portugal"}]},{"given":"Alexander","family":"Erban","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Pflanzenphysiologie , 14476 Potsdam-Golm, Germany"}]},{"given":"Catarina","family":"Neves","sequence":"additional","affiliation":[{"name":"University of Lisbon BioISI - Biosystems and Integrative Sciences Institute, Faculty of Sciences, , Campo Grande, 1749-016 Lisboa, Portugal"}]},{"given":"Pedro","family":"Reis","sequence":"additional","affiliation":[{"name":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food-Research Center , Associated Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisbon, Portugal"}]},{"given":"Marcelo","family":"Pereira","sequence":"additional","affiliation":[{"name":"University of Lisbon BioISI - Biosystems and Integrative Sciences Institute, Faculty of Sciences, , Campo Grande, 1749-016 Lisboa, Portugal"}]},{"given":"Cecilia","family":"Rego","sequence":"additional","affiliation":[{"name":"LEAF\u2014Linking Landscape, Environment, Agriculture and Food-Research Center , Associated Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisbon, Portugal"}]},{"given":"Margarida","family":"Gama-Carvalho","sequence":"additional","affiliation":[{"name":"University of Lisbon BioISI - Biosystems and Integrative Sciences Institute, Faculty of Sciences, , Campo Grande, 1749-016 Lisboa, Portugal"}]},{"given":"Joachim","family":"Kopka","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Pflanzenphysiologie , 14476 Potsdam-Golm, Germany"}]},{"given":"Ana Margarida","family":"Fortes","sequence":"additional","affiliation":[{"name":"University of Lisbon BioISI - Biosystems and Integrative Sciences Institute, Faculty of Sciences, , Campo Grande, 1749-016 Lisboa, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"2022120508235227800_ref1","article-title":"Grapevine pathogenic microorganisms: understanding infection strategies and host response scenarios","volume":"7","author":"Armijo","year":"2016","journal-title":"Plant Sci"},{"key":"2022120508235227800_ref2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.foodres.2017.11.052","article-title":"Postharvest dehydration induces variable changes in the primary metabolism of grape berries","volume":"105","author":"Conde","year":"2018","journal-title":"Food Res Int"},{"key":"2022120508235227800_ref3","article-title":"Emerging trends in molecular interactions between plants and the broad host range fungal pathogens Botrytis cinerea and Sclerotinia sclerotiorum","volume":"7","author":"Mbengue","year":"2016","journal-title":"Plant Sci"},{"key":"2022120508235227800_ref4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/07388551.2016.1271767","article-title":"Mechanisms and strategies of plant defense against Botrytis cinerea","volume":"37","author":"AbuQamar","year":"2017","journal-title":"Crit Rev Biotechnol"},{"key":"2022120508235227800_ref5","article-title":"Infection strategies deployed by Botrytis cinerea, Fusarium acuminatum, and Rhizopus stolonifer as a function of tomato fruit ripening Stage","volume":"10","author":"Petrasch","year":"2019","journal-title":"Plant Sci"},{"key":"2022120508235227800_ref6","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44279","article-title":"Plant\u2013necrotroph co-transcriptome networks illuminate a metabolic battlefield","volume":"8","author":"Zhang","year":"2019","journal-title":"elife"},{"key":"2022120508235227800_ref7","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4161\/viru.29798","article-title":"The role of effectors and host immunity in plant\u2013necrotrophic fungal interactions","volume":"5","author":"Wang","year":"2014","journal-title":"Virulence"},{"key":"2022120508235227800_ref8","first-page":"749","article-title":"PAMPs, PRRs, effectors and R-genes associated with citrus\u2013pathogen interactions","volume":"119","author":"Dalio","year":"2017","journal-title":"Ann Bot"},{"key":"2022120508235227800_ref9","doi-asserted-by":"crossref","first-page":"13798","DOI":"10.1038\/s41598-020-70485-1","article-title":"RLP23 is required for Arabidopsis immunity against the grey mould pathogen Botrytis cinerea","volume":"10","author":"Ono","year":"2020","journal-title":"Sci Rep"},{"key":"2022120508235227800_ref10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1104\/pp.113.230698","article-title":"Fungal Endopolygalacturonases are recognized as microbe-associated molecular patterns by the Arabidopsis receptor-like protein RESPONSIVENESS TO BOTRYTIS POLYGALACTURONASES1","volume":"164","author":"Zhang","year":"2014","journal-title":"Plant Physiol"},{"key":"2022120508235227800_ref11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature05286","article-title":"The plant immune system","volume":"444","author":"Jones","year":"2006","journal-title":"Nature"},{"key":"2022120508235227800_ref12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-arplant-043014-114623","article-title":"Fungal effectors and plant susceptibility","volume":"66","author":"Lo Presti","year":"2015","journal-title":"Annu Rev Plant Biol"},{"key":"2022120508235227800_ref13","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1094\/PHYTO.2003.93.12.1505","article-title":"Osmotin and thaumatin from grape: a putative general defense mechanism against pathogenic fungi","volume":"93","author":"Monteiro","year":"2003","journal-title":"Phytopathology"},{"key":"2022120508235227800_ref14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1104\/pp.106.079467","article-title":"Reactive oxygen species Signaling in response to pathogens","volume":"141","author":"Torres","year":"2006","journal-title":"Plant Physiol"},{"key":"2022120508235227800_ref15","first-page":"1","article-title":"Plant defences against fungal attack: perception and signal transduction","author":"Xiao","year":"2019","journal-title":"In: eLS American Cancer Society"},{"key":"2022120508235227800_ref16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.plantsci.2019.01.024","article-title":"The study of hormonal metabolism of Trincadeira and Syrah cultivars indicates new roles of salicylic acid, jasmonates, ABA and IAA during grape ripening and upon infection with Botrytis cinerea","volume":"283","author":"Coelho","year":"2019","journal-title":"Plant Sci"},{"key":"2022120508235227800_ref17","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1094\/PHYTO.2004.94.8.850","article-title":"Botrytis cinerea infection of grape flowers: light and electron Microscopical studies of infection sites","volume":"94","author":"Viret","year":"2004","journal-title":"Phytopathology"},{"key":"2022120508235227800_ref18","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/pce.12937","article-title":"Molecular analysis of the early interaction between the grapevine flower and Botrytis cinerea reveals that prompt activation of specific host pathways leads to fungus quiescence","volume":"40","author":"Haile","year":"2017","journal-title":"Plant Cell Environ"},{"key":"2022120508235227800_ref19","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1046\/j.1365-2958.2003.03866.x","article-title":"The tetraspanin BcPls1 is required for appressorium-mediated penetration of Botrytis cinerea into host plant leaves","volume":"51","author":"Gourgues","year":"2004","journal-title":"Mol Microbiol"},{"key":"2022120508235227800_ref20","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.tplants.2018.03.016","article-title":"Many shades of Grey in Botrytis\u2013host plant interactions","volume":"23","author":"Veloso","year":"2018","journal-title":"Trends Plant Sci"},{"key":"2022120508235227800_ref21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142221","article-title":"Large-scale Transcriptome analysis of cucumber and Botrytis cinerea during infection","volume":"10","author":"Kong","year":"2015","journal-title":"PLoS One"},{"key":"2022120508235227800_ref22","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmpp.2020.101514","article-title":"RNA sequencing-based transcriptome analysis of kiwifruit infected by Botrytis cinerea","volume":"111","author":"Zambounis","year":"2020","journal-title":"Physiol Mol Plant Pathol"},{"key":"2022120508235227800_ref23","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1094\/MPMI-05-20-0109-A","article-title":"Transcriptome profiling data of Botrytis cinereaInfection on whole PlantSolanum lycopersicum","volume":"33","author":"Srivastava","year":"2020","journal-title":"MPMI"},{"key":"2022120508235227800_ref24","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1094\/MPMI-02-15-0039-R","article-title":"Analysis of the molecular dialogue between Gray Mold (Botrytis cinerea) and grapevine (Vitis vinifera) reveals a clear shift in Defense mechanisms during berry ripening","volume":"28","author":"Kelloniemi","year":"2015","journal-title":"MPMI"},{"key":"2022120508235227800_ref25","first-page":"1704","article-title":"Dual Transcriptome and metabolic analysis of Vitis vinifera cv. Pinot noir berry and Botrytis cinerea during quiescence and egressed infection","volume":"10","author":"Haile","year":"2019","journal-title":"Plant Sci"},{"key":"2022120508235227800_ref26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140444","article-title":"A mechanistic model of Botrytis cinerea on grapevines that includes weather, vine growth stage, and the Main infection pathways","volume":"10","author":"Gonz\u00e1lez-Dom\u00ednguez","year":"2015","journal-title":"PLoS One"},{"key":"2022120508235227800_ref27","doi-asserted-by":"crossref","first-page":"7237","DOI":"10.1021\/jf200664t","article-title":"Metabolic influence of Botrytis cinerea infection in Champagne Base wine","volume":"59","author":"Hong","year":"2011","journal-title":"J Agric Food Chem"},{"key":"2022120508235227800_ref28","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/jxb\/eru517","article-title":"Transcriptome and metabolome reprogramming in Vitis vinifera cv. Trincadeira berries upon infection with Botrytis cinerea","volume":"66","author":"Agudelo-Romero","year":"2015","journal-title":"J Exp Bot"},{"key":"2022120508235227800_ref29","article-title":"Insights into molecular and metabolic events associated with fruit response to post-harvest fungal pathogens","volume":"6","author":"Alkan","year":"2015","journal-title":"Plant Sci"},{"key":"2022120508235227800_ref30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1755-0238.1995.tb00086.x","article-title":"Growth stages of the grapevine: adoption of a system for identifying grapevine growth stages","volume":"1","author":"Coombe","year":"1995","journal-title":"Aust J Grape Wine Res"},{"key":"2022120508235227800_ref31","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4161\/psb.4.2.7580","article-title":"Very long chain fatty acid and lipid signaling in the response of plants to pathogens","volume":"4","author":"Raffaele","year":"2009","journal-title":"Plant Signal Behav"},{"key":"2022120508235227800_ref32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40659-018-0195-2","article-title":"The physiological and molecular mechanism of brassinosteroid in response to stress: a review","volume":"51","author":"Anwar","year":"2018","journal-title":"Biol Res"},{"key":"2022120508235227800_ref33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature06148","article-title":"The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla","volume":"449","author":"Jaillon","year":"2007","journal-title":"Nature"},{"key":"2022120508235227800_ref34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/mpp.12384","article-title":"A gapless genome sequence of the fungus Botrytis cinerea","volume":"18","author":"van Kan","year":"2017","journal-title":"Mol Plant Pathol"},{"key":"2022120508235227800_ref35","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/bioinformatics\/btg455","article-title":"FatiGO: a web tool for finding significant associations of gene ontology terms with groups of genes","volume":"20","author":"Al-Shahrour","year":"2004","journal-title":"Bioinformatics"},{"key":"2022120508235227800_ref36","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1094\/MPMI-21-5-0507","article-title":"Plant receptor-like serine threonine kinases: roles in signaling and plant defense","volume":"21","author":"Afzal","year":"2008","journal-title":"Mol Plant-Microbe Interact"},{"key":"2022120508235227800_ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(04)34001-5","article-title":"Leucine-rich repeat receptor kinases in plants: structure, function, and signal transduction pathways","volume":"234","author":"Torii","year":"2004","journal-title":"Int Rev Cytol"},{"key":"2022120508235227800_ref38","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2016.00353","article-title":"Structural and functional analysis of the GRAS gene family in grapevine indicates a role of GRAS proteins in the control of development and stress Responses","volume":"7","author":"Grimplet","year":"2016","journal-title":"Front Plant Sci"},{"key":"2022120508235227800_ref39","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1105\/tpc.104.025833","article-title":"Antagonistic interaction between Abscisic acid and Jasmonate-ethylene Signaling pathways modulates Defense gene expression and disease resistance in Arabidopsis","volume":"16","author":"Anderson","year":"2004","journal-title":"Plant Cell"},{"key":"2022120508235227800_ref40","article-title":"\u2018Omics\u2019 and plant responses to Botrytis cinerea","volume":"7","author":"AbuQamar","year":"2016","journal-title":"Plant Sci"},{"key":"2022120508235227800_ref41","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1094\/MPMI-18-0602","article-title":"Functional analysis of the cytochrome P450 monooxygenase gene bcbot1 of Botrytis cinerea indicates that botrydial is a strain-specific virulence factor","volume":"18","author":"Siewers","year":"2005","journal-title":"Mol Plant-Microbe Interact"},{"key":"2022120508235227800_ref42","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1094\/MPMI-11-16-0227-R","article-title":"Comparative proteomics reveals the potential targets of BcNoxR, a putative regulatory subunit of NADPH oxidase of Botrytis cinerea","volume":"29","author":"Li","year":"2016","journal-title":"MPMI"},{"key":"2022120508235227800_ref43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2007.00930.x","article-title":"Botrytis cinerea virulence factors: new insights into a necrotrophic and polyphageous pathogen","volume":"277","author":"Choquer","year":"2007","journal-title":"FEMS Microbiol Lett"},{"key":"2022120508235227800_ref44","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fpls.2014.00435","article-title":"Genome-wide transcriptional profiling of Botrytis cinerea genes targeting plant cell walls during infections of different hosts","volume":"5","author":"Blanco-Ulate","year":"2014","journal-title":"Front Plant Sci"},{"key":"2022120508235227800_ref45","doi-asserted-by":"crossref","first-page":"22044","DOI":"10.1073\/pnas.1009845107","article-title":"Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model","volume":"107","author":"Becker","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022120508235227800_ref46","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/mpp.12794","article-title":"Grey mould of strawberry, a devastating disease caused by the ubiquitous necrotrophic fungal pathogen Botrytis cinerea","volume":"20","author":"Petrasch","year":"2019","journal-title":"Mol Plant Pathol"},{"key":"2022120508235227800_ref47","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1469-8137.2006.01777.x","article-title":"Calcium in plant defence-signalling pathways","volume":"171","author":"Lecourieux","year":"2006","journal-title":"New Phytol"},{"key":"2022120508235227800_ref48","first-page":"427","article-title":"Calmodulin gene expression in response to mechanical wounding and Botrytis cinerea infection in tomato fruit","volume":"3","author":"Peng","year":"2014","journal-title":"Plan Theory"},{"key":"2022120508235227800_ref49","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1104\/pp.111.192575","article-title":"Plasma membrane calcium ATPases are important components of receptor-mediated Signaling in plant immune responses and development","volume":"159","author":"Frei dit Frey","year":"2012","journal-title":"Plant Physiol"},{"key":"2022120508235227800_ref50","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1105\/tpc.111.087346","article-title":"Transcription dynamics in plant immunity","volume":"23","author":"Moore","year":"2011","journal-title":"Plant Cell"},{"key":"2022120508235227800_ref51","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1105\/tpc.014167","article-title":"The BOTRYTIS SUSCEPTIBLE1 gene encodes an R2R3MYB transcription factor protein that is required for biotic and abiotic stress responses in Arabidopsis","volume":"15","author":"Mengiste","year":"2003","journal-title":"Plant Cell"},{"key":"2022120508235227800_ref52","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1104\/pp.111.192641","article-title":"Arabidopsis WRKY33 is a key transcriptional regulator of hormonal and metabolic responses toward Botrytis cinerea infection","volume":"159","author":"Birkenbihl","year":"2012","journal-title":"Plant Physiol"},{"key":"2022120508235227800_ref53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004800","article-title":"Novel disease susceptibility factors for fungal Necrotrophic pathogens in Arabidopsis","volume":"11","author":"Dob\u00f3n","year":"2015","journal-title":"PLoS Pathog"},{"key":"2022120508235227800_ref54","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2014.00017","article-title":"Regulation of primary plant metabolism during plant-pathogen interactions and its contribution to plant defense","volume":"5","author":"Rojas","year":"2014","journal-title":"Front Plant Sci"},{"key":"2022120508235227800_ref55","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.plaphy.2018.03.033","article-title":"An altered tocopherol composition in chloroplasts reduces plant resistance to Botrytis cinerea","volume":"127","author":"Cela","year":"2018","journal-title":"Plant Physiol Biochem"},{"key":"2022120508235227800_ref56","doi-asserted-by":"crossref","first-page":"7998","DOI":"10.1021\/jf502033s","article-title":"Changes in the Triterpenoid content of Cuticular waxes during fruit ripening of eight grape (Vitis vinifera) cultivars grown in the upper Rhine Valley","volume":"62","author":"Pensec","year":"2014","journal-title":"J Agric Food Chem"},{"key":"2022120508235227800_ref57","doi-asserted-by":"crossref","DOI":"10.1016\/j.scienta.2019.108636","article-title":"Antifungal efficacy of ursolic acid in control of Alternaria alternata causing black spot rot on apple fruit and possible mechanisms involved","volume":"256","author":"Shu","year":"2019","journal-title":"Sci Hortic"},{"key":"2022120508235227800_ref58","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/ppl.12256","article-title":"Epigallocatechin-3-gallate functions as a physiological regulator by modulating the jasmonic acid pathway","volume":"153","author":"Hong","year":"2015","journal-title":"Physiol Plant"},{"key":"2022120508235227800_ref59","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.postharvbio.2007.08.008","article-title":"Hexanal reduces infection of tomatoes by Botrytis cinerea whilst maintaining quality","volume":"47","author":"Utto","year":"2008","journal-title":"Postharvest Biol Technol"},{"key":"2022120508235227800_ref60","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1038\/s41598-018-19776-2","article-title":"Downy mildew symptoms on grapevines can be reduced by volatile organic compounds of resistant genotypes","volume":"8","author":"Lazazzara","year":"2018","journal-title":"Sci Rep"},{"key":"2022120508235227800_ref61","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/1365-2745.12340","article-title":"Plant volatiles cause direct, induced and associational resistance in common bean to the fungal pathogenColletotrichum lindemuthianum","volume":"103","author":"Quintana-Rodriguez","year":"2015","journal-title":"J Ecol"},{"key":"2022120508235227800_ref62","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1111\/pce.12330","article-title":"Ecology of plant volatiles: taking a plant community perspective","volume":"37","author":"Pierik","year":"2014","journal-title":"Plant Cell Environ"},{"key":"2022120508235227800_ref63","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.fgb.2017.07.004","article-title":"Temporal transcriptome analysis of the white-rot fungus Obba rivulosa shows expression of a constitutive set of plant cell wall degradation targeted genes during growth on solid spruce wood","volume":"112","author":"Marinovi\u0107","year":"2018","journal-title":"Fungal Genet Biol"},{"key":"2022120508235227800_ref64","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1469-8137.2011.03802.x","article-title":"BcSpl1, a cerato-platanin family protein, contributes to Botrytis cinerea virulence and elicits the hypersensitive response in the host","volume":"192","author":"Fr\u00edas","year":"2011","journal-title":"New Phytol"},{"key":"2022120508235227800_ref65","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.3390\/ijms23063034","article-title":"Botrytis cinerea loss and restoration of virulence during in vitro culture follows flux in global DNA methylation","volume":"23","author":"Breen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2022120508235227800_ref66","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.funbio.2011.06.009","article-title":"LongSAGE gene-expression profiling of Botrytis cinerea germination suppressed by resveratrol, the major grapevine phytoalexin","volume":"115","author":"Zheng","year":"2011","journal-title":"Fungal Biol"},{"key":"2022120508235227800_ref67","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/fqsafe\/fyy016","article-title":"Pathogenic mechanisms and control strategies of Botrytis cinerea causing post-harvest decay in fruits and vegetables","volume":"2","author":"Hua","year":"2018","journal-title":"Food Qual Saf"},{"key":"2022120508235227800_ref68","article-title":"Transcriptional modulation of polyamine metabolism in fruit species under abiotic and biotic Stress","volume":"10","author":"Fortes","year":"2019","journal-title":"Plant Sci"},{"key":"2022120508235227800_ref69","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-313X.2009.03794.x","article-title":"The ABC transporter BcatrB from Botrytis cinerea exports camalexin and is a virulence factor on Arabidopsis thaliana","volume":"58","author":"Stefanato","year":"2009","journal-title":"Plant J"},{"key":"2022120508235227800_ref70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-10860-3","article-title":"MFS transporter from Botrytis cinerea provides tolerance to glucosinolate-breakdown products and is required for pathogenicity","volume":"10","author":"Vela-Corc\u00eda","year":"2019","journal-title":"Nat Commun"},{"key":"2022120508235227800_ref71","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/mpp.12788","article-title":"A novel Botrytis cinerea-specific gene BcHBF1 enhances virulence of the grey mould fungus via promoting host penetration and invasive hyphal development","volume":"20","author":"Liu","year":"2019","journal-title":"Mol Plant Pathol"},{"key":"2022120508235227800_ref72","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1186\/s12870-019-2139-6","article-title":"Genome-wide characterization of the rose (Rosa chinensis) WRKY family and role of RcWRKY41 in gray mold resistance","volume":"19","author":"Liu","year":"2019","journal-title":"BMC Plant Biol"},{"key":"2022120508235227800_ref73","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/j.1469-8137.2009.02890.x","article-title":"Dynamic carbon transfer during pathogenesis of sunflower by the necrotrophic fungus Botrytis cinerea: from plant hexoses to mannitol","volume":"183","author":"Dulermo","year":"2009","journal-title":"New Phytol"},{"key":"2022120508235227800_ref74","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1046\/j.1365-2958.2003.03412.x","article-title":"The glyoxylate cycle is required for temporal regulation of virulence by the plant pathogenic fungus Magnaporthe grisea","volume":"47","author":"Wang","year":"2003","journal-title":"Mol Microbiol"},{"key":"2022120508235227800_ref75","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1534\/genetics.120.303070","article-title":"Pathogen genetic control of Transcriptome variation in theArabidopsis thaliana\u2013Botrytis cinereaPathosystem","volume":"215","author":"Soltis","year":"2020","journal-title":"Genetics"},{"key":"2022120508235227800_ref76","article-title":"Increase in ribosomal proteins activity: translational reprogramming in Vanilla planifolia jacks., against Fusarium infection","author":"MTS de la","year":"2019","journal-title":"bioRxiv"},{"key":"2022120508235227800_ref77","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1094\/MPMI-01-13-0005-R","article-title":"Host-induced gene silencing in barley powdery mildew reveals a class of Ribonuclease-like effectors","volume":"26","author":"Pliego","year":"2013","journal-title":"MPMI"},{"key":"2022120508235227800_ref78","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/1471-2229-11-149","article-title":"Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening","volume":"11","author":"Fortes","year":"2011","journal-title":"BMC Plant Biol"},{"key":"2022120508235227800_ref79","article-title":"FastQC: a quality control tool for high throughput sequence data","author":"Andrews","year":"2010"},{"key":"2022120508235227800_ref80","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"key":"2022120508235227800_ref81","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"2022120508235227800_ref82","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2022120508235227800_ref83","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/1756-0500-5-213","article-title":"Comparative analysis of grapevine whole-genome gene predictions, functional annotation, categorization and integration of the predicted gene sequences","volume":"5","author":"Grimplet","year":"2012","journal-title":"BMC Research Notes"},{"key":"2022120508235227800_ref84","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/978-1-4939-0844-8_14","article-title":"Profiling methods to identify cold-regulated primary metabolites using gas chromatography coupled to mass spectrometry","volume":"1166","author":"Dethloff","year":"2014","journal-title":"Methods Mol Biol"},{"key":"2022120508235227800_ref85","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.plaphy.2013.02.024","article-title":"Study of polyamines during grape ripening indicate an important role of polyamine catabolism","volume":"67","author":"Agudelo-Romero","year":"2013","journal-title":"Plant Physiol Biochem"},{"key":"2022120508235227800_ref86","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1093\/bioinformatics\/bti236","article-title":"GMD@CSB.DB: the Golm Metabolome database","volume":"21","author":"Kopka","year":"2005","journal-title":"Bioinformatics"},{"key":"2022120508235227800_ref87","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s11306-010-0198-7","article-title":"Decision tree supported substructure prediction of metabolites from GC-MS profiles","volume":"6","author":"Hummel","year":"2010","journal-title":"Metabolomics"},{"key":"2022120508235227800_ref88","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/bioinformatics\/btn023","article-title":"TagFinder for the quantitative analysis of gas chromatography--mass spectrometry (GC-MS)-based metabolite profiling experiments","volume":"24","author":"Luedemann","year":"2008","journal-title":"Bioinformatics"},{"key":"2022120508235227800_ref89","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jchromb.2008.04.042","article-title":"Retention index thresholds for compound matching in GC-MS metabolite profiling","volume":"871","author":"Strehmel","year":"2008","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"2022120508235227800_ref90","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11101-012-9241-9","article-title":"Fruit cuticular waxes as a source of biologically active triterpenoids","volume":"11","author":"Szakiel","year":"2012","journal-title":"Phytochem Rev"},{"key":"2022120508235227800_ref91","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.phytol.2019.02.009","article-title":"Triterpenoid profiles of the leaves of wild and domesticated grapevines","volume":"30","author":"Burdziej","year":"2019","journal-title":"Phytochem Lett"},{"key":"2022120508235227800_ref92","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-1-4939-7819-9_16","article-title":"Acquisition of Volatile Compounds by gas chromatography-mass spectrometry (GC-MS)","volume":"1778","author":"Vallarino","year":"2018","journal-title":"Methods Mol Biol"},{"key":"2022120508235227800_ref93","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1021\/ac900036d","article-title":"MetAlign: interface-driven, versatile metabolomics tool for hyphenated full-scan mass spectrometry data preprocessing","volume":"81","author":"Lommen","year":"2009","journal-title":"Anal Chem"},{"key":"2022120508235227800_ref94","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","author":"Gu","year":"2016"}],"container-title":["Horticulture Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hr\/advance-article-pdf\/doi\/10.1093\/hr\/uhac217\/45967793\/uhac217.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hr\/article-pdf\/doi\/10.1093\/hr\/uhac217\/47546943\/uhac217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hr\/article-pdf\/doi\/10.1093\/hr\/uhac217\/47546943\/uhac217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T08:24:51Z","timestamp":1670228691000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hr\/article\/doi\/10.1093\/hr\/uhac217\/6710369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":94,"URL":"https:\/\/doi.org\/10.1093\/hr\/uhac217","relation":{},"ISSN":["2052-7276"],"issn-type":[{"value":"2052-7276","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022]]},"published":{"date-parts":[[2022]]},"article-number":"uhac217"}}