{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T22:46:47Z","timestamp":1776293207576,"version":"3.50.1"},"reference-count":107,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011925","name":"ESHRE","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"Abstract<\/jats:title>\n \n STUDY QUESTION<\/jats:title>\n Which research topics in the area of infertility should be prioritized in the allocation of research resources?<\/jats:p>\n <\/jats:sec>\n \n SUMMARY ANSWER<\/jats:title>\n Twelve research priorities were formulated, spanning the following areas: preventing infertility and preserving fertility, gynaecological diseases, male infertility, optimizing fertility treatments, optimizing psychosocial support and deepening knowledge on preimplantation development and early pregnancy.<\/jats:p>\n <\/jats:sec>\n \n WHAT IS KNOWN ALREADY<\/jats:title>\n Many research gaps related to infertility and its management remain understudied and underfunded, making it important to set priorities to ensure appropriate allocation of research resources.<\/jats:p>\n <\/jats:sec>\n \n STUDY DESIGN, SIZE, DURATION<\/jats:title>\n The European Society of Human Reproduction and Embryology (ESHRE) appointed a multidisciplinary working group, including a patient representative, to develop a list of research priorities related to infertility, which are relevant to researchers and institutions that fund research.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n A list of research topics was collated based on the recommendations for future research formulated in ESHRE\u2019s evidence-based guidelines and suggestions submitted by ESHRE\u2019s Special Interest Groups as call topics for the ESHRE research grants. A scoring tool was developed to assess the expected impact of research on each topic on individuals, society and scientific advancement. Topics were scored independently by the working group members and the 12 topics with the highest scores were selected for presentation in this paper.<\/jats:p>\n <\/jats:sec>\n \n MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n Using our newly developed scoring tool, we have identified 12 research priorities that broadly fall under six areas. These are preventing infertility and preserving fertility, gynaecological diseases, male infertility, optimizing fertility treatments (two priorities per area selected), optimizing psychosocial support (one priority selected) and deepening knowledge on preimplantation development and early pregnancy (three priorities selected).<\/jats:p>\n <\/jats:sec>\n \n LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n The impact scoring tool would benefit from further testing and refinement in future projects. The scoring of some impact indicators is heavily based on the judgment and expertise of the scorers, which was accounted for by ensuring representation of knowledge and experience from all relevant disciplines and subject areas as well as the patient perspective within the working group.<\/jats:p>\n <\/jats:sec>\n \n WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n This paper may serve to stimulate further thought and discussion within the infertility research community on the potential impact of proposed and ongoing research. It will furthermore inform and encourage policy makers involved in research funding allocation and contribute to a more efficient and purposeful allocation of research resources towards infertility research.<\/jats:p>\n <\/jats:sec>\n \n STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n The technical support for this project was provided by ESHRE. A.C. reports employment at Juno Genetics. Y.C. reports a grant from Guerbet and honoraria from Ferring, Merck, Abbot, Nordic Pharma and Organon. G.C. reports consulting fees from Gedeon Richter and honoraria from Cooper Surgical. S.G. reports the development of www.myjourney.pt licensed under a CC BY-NC-SA 4.0 licence. J.K.-B. reports grants from the NIHR Evaluation and Studies Coordinating Centre, the Gates Foundation, the Economic and Social Research Council, BAYER Consumer Health and MRC Confidence in Concept; honoraria from Ferring and Cooper Surgical; travel support from Ferring, Cooper Surgical, Congressworks LLP, Deutsche Gesellschaft f\u00fcr Andrologie e. V., BAYER, University of Munster and ESHRE; a patent for microchannel sperm cell preparation; and a leadership or fiduciary role in the Association of Clinical and Reproductive Scientists. A.P. reports grants (to her institution) and consulting fees from Gedeon Richter, Ferring, Merck A\/S and Cryos; honoraria from Gedeon Richter, Ferring, Merck A\/S and Organon; and travel support (to her institution) from Gedeon Richter. H.S.N. reports grants from Freya Biosciences ApS, Ferring Pharmaceuticals, BioInnovation Institute, Ministry of Education, Novo Nordic Foundation, Augustinus Fonden, Oda og Hans Svenningsens Fond, Demant Fonden, Ole Kirks Fond and the Independent Research Fund Denmark; speaker\u2019s fees from Ferring, Merck A\/S, Astra Zeneca, Cook Medical, Gedeon Richter, Ibsa Nordic, Novo Nordisk A\/S; co-development of an app with the Maternity Foundation; and co-founding a project with Lulu Health. The remaining authors (J.T., A.A., I.D., C.F., M.G., A.S.L., M.M.-R., V.N., A.O., N.R., M.S.-L., P.T., N.V., S.V. and K.S.) have nothing to declare.<\/jats:p>\n <\/jats:sec>\n \n TRIAL REGISTRATION NUMBER<\/jats:title>\n N\/A<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humrep\/deaf150","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T23:28:02Z","timestamp":1755041282000},"page":"1829-1842","source":"Crossref","is-referenced-by-count":6,"title":["ESHRE\u2019s key research priorities in infertility: maximizing impact on science, people and society"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0883-7372","authenticated-orcid":false,"given":"Johanna","family":"Tassot","sequence":"first","affiliation":[{"name":"European Society of Human Reproduction and Embryology, Central Office , Strombeek-Bever,","place":["Belgium"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-912X","authenticated-orcid":false,"given":"Aisling","family":"Ahlstrom","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance, Livio Gothenburg , Gothenburg,","place":["Sweden"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0109-323X","authenticated-orcid":false,"given":"Antonio","family":"Capalbo","sequence":"additional","affiliation":[{"name":"Unit of Medical Genetics, Center for Advanced Studies and Technology (CAST), \u201cG. d\u2018Annunzio\u201d University of Chieti-Pescara , Chieti,","place":["Italy"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7687-4597","authenticated-orcid":false,"given":"Ying","family":"Cheong","sequence":"additional","affiliation":[{"name":"Human Development and Health, Faculty of Medicine, University of Southampton , Southampton,","place":["UK"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1635-9205","authenticated-orcid":false,"given":"Giovanni","family":"Coticchio","sequence":"additional","affiliation":[{"name":"IVIRMA Global Research Alliance, IVIRMA ITALIA , Rome,","place":["Italy"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8522-2512","authenticated-orcid":false,"given":"Ilse","family":"Delbaere","sequence":"additional","affiliation":[{"name":"VIVES University of Applied Sciences, Research Group Health Promotion , Kortrijk,","place":["Belgium"]}]},{"given":"Christina","family":"Fadler","sequence":"additional","affiliation":[{"name":"Fertility Europe , Brussels,","place":["Belgium"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-2004","authenticated-orcid":false,"given":"Sofia","family":"Gameiro","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Research Centre Wales, School of Psychology, Cardiff University , Cardiff, Wales"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9928-9673","authenticated-orcid":false,"given":"Mari\u00ebtte","family":"Goddijn","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine, Department Obstetrics and Gynecology, Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam , Amsterdam,","place":["The Netherlands"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2833-8970","authenticated-orcid":false,"given":"Jackson","family":"Kirkman-Brown","sequence":"additional","affiliation":[{"name":"Centre for Human Reproductive Science, School of Medical Sciences, College of Medicine & Health, University of Birmingham , Birmingham,","place":["UK"]},{"name":"Birmingham Women\u2019s Fertility Centre, Birmingham Women\u2019s Hospital, Edgbaston , Birmingham,","place":["UK"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-2802","authenticated-orcid":false,"given":"Antonio Simone","family":"Lagan\u00e0","sequence":"additional","affiliation":[{"name":"Unit of Obstetrics and Gynecology, \u201cPaolo Giaccone\u201d Hospital, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo , Palermo,","place":["Italy"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7542-0497","authenticated-orcid":false,"given":"Mariana","family":"Moura-Ramos","sequence":"additional","affiliation":[{"name":"Clinical Psychology Unit, Unidade Local de Sa\u00fade de Coimbra , Coimbra,","place":["Portugal"]},{"name":"Center for Research in Neuropsychology and Cognitive-Behavioural Intervention, University of Coimbra , Coimbra,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-1366","authenticated-orcid":false,"given":"Verena","family":"Nordhoff","sequence":"additional","affiliation":[{"name":"Centre of Reproductive Medicine and Andrology, University Hospital of M\u00fcnster (UKM) , M\u00fcnster,","place":["Germany"]}]},{"given":"Ariana","family":"Orli\u0107","sequence":"additional","affiliation":[{"name":"European Society of Human Reproduction and Embryology, Central Office , Strombeek-Bever,","place":["Belgium"]},{"name":"Faculty of Health, Medicine and Life Sciences, Maastricht University , Maastricht,","place":["The Netherlands"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8340-104X","authenticated-orcid":false,"given":"Anja","family":"Pinborg","sequence":"additional","affiliation":[{"name":"Fertility Clinic, Department of Gynecology, Fertility and Obstetrics, Rigshospitalet, Copenhagen University Hospital , Copenhagen,","place":["Denmark"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-1111","authenticated-orcid":false,"given":"Nathalie","family":"Rives","sequence":"additional","affiliation":[{"name":"Univ Rouen Normandie, Inserm U1239, NorDIC, Team \u201cAdrenal and Gonadal Pathophysiology\u201d, Rouen University Hospital, Biology of Reproduction-CECOS Laboratory , Rouen,","place":["France"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8002-4648","authenticated-orcid":false,"given":"Mariana","family":"Sousa-Leite","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Research Centre Wales, School of Psychology, Cardiff University , Cardiff, Wales"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-8103","authenticated-orcid":false,"given":"Henriette Svarre","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Copenhagen University Hospital , Hvidovre,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen,","place":["Denmark"]}]},{"given":"Petra","family":"Thorn","sequence":"additional","affiliation":[{"name":"Private Practice (Social Worker, Social Therapist, Family Therapist) , Moerfelden,","place":["Germany"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8046-6799","authenticated-orcid":false,"given":"Nathalie","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"European Society of Human Reproduction and Embryology, Central Office , Strombeek-Bever,","place":["Belgium"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5088-3003","authenticated-orcid":false,"given":"Stephane","family":"Viville","sequence":"additional","affiliation":[{"name":"Laboratoire de Diagnostic G\u00e9n\u00e9tique, UF3472-g\u00e9n\u00e9tique de l\u2018infertilit\u00e9, H\u00f4pitaux Universitaires de Strasbourg , Strasbourg,","place":["France"]},{"name":"Institute for Genetics and Molecular and Cellular Biology (IGBMC), University of Strasbourg, CNRS UMR7104, INSERM U1258 , Illkirch,","place":["France"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2311-9034","authenticated-orcid":false,"given":"Karen","family":"Sermon","sequence":"additional","affiliation":[{"name":"Research Group Genetics Reproduction and Development (GRAD), Vrije Universiteit Brussel , Brussels,","place":["Belgium"]}]}],"member":"286","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"2025100301515625400_deaf150-B1","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1093\/humrep\/deae230","article-title":"Paternal age, de novo mutations, and offspring health? New directions for an ageing problem","volume":"39","author":"Aitken","year":"2024","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B2","doi-asserted-by":"crossref","first-page":"hoaa052","DOI":"10.1093\/hropen\/hoaa052","article-title":"ESHRE guideline: female fertility preservation","volume":"2020","author":"Anderson","year":"2020","journal-title":"Hum Reprod Open"},{"key":"2025100301515625400_deaf150-B3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.fertnstert.2023.12.008","article-title":"Noninvasive diagnostic imaging for endometriosis part 1: a systematic review of recent developments in ultrasound, combination imaging, and artificial intelligence","volume":"121","author":"Avery","year":"2024","journal-title":"Fertil Steril"},{"key":"2025100301515625400_deaf150-B4","doi-asserted-by":"crossref","first-page":"hoac009","DOI":"10.1093\/hropen\/hoac009","article-title":"ESHRE guideline: endometriosis","volume":"2022","author":"Becker","year":"2022","journal-title":"Hum Reprod Open"},{"key":"2025100301515625400_deaf150-B5","first-page":"hoad002","article-title":"ESHRE guideline: recurrent pregnancy loss: an update in 2022","volume":"2023","author":"Bender Atik","year":"2023","journal-title":"Hum Reprod Open"},{"key":"2025100301515625400_deaf150-B6","doi-asserted-by":"crossref","first-page":"101141","DOI":"10.1016\/j.gim.2024.101141","article-title":"Lethal phenotypes in Mendelian disorders","volume":"26","author":"Cacheiro","year":"2024","journal-title":"Genet Med"},{"key":"2025100301515625400_deaf150-B7","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1093\/humrep\/deae163","article-title":"Survey on ART and IUI: legislation, regulation, funding, and registries in European countries\u2014an update","volume":"39","author":"Calhaz-Jorge","year":"2024","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B8","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.rbmo.2022.05.009","article-title":"Maternal exome analysis for the diagnosis of oocyte maturation defects and early embryonic developmental arrest","volume":"45","author":"Capalbo","year":"2022","journal-title":"Reprod Biomed Online"},{"key":"2025100301515625400_deaf150-B9","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.ajhg.2022.07.009","article-title":"On the reproductive capabilities of aneuploid human preimplantation embryos","volume":"109","author":"Capalbo","year":"2022","journal-title":"Am J Hum Genet"},{"key":"2025100301515625400_deaf150-B10","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/humupd\/dmaa044","article-title":"Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual genomic data","volume":"27","author":"Capalbo","year":"2021","journal-title":"Hum Reprod Update"},{"key":"2025100301515625400_deaf150-B11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.2021.4788","article-title":"Diagnosis and management of infertility: a review","volume":"326","author":"Carson","year":"2021","journal-title":"JAMA"},{"key":"2025100301515625400_deaf150-B12","doi-asserted-by":"crossref","first-page":"hox008","DOI":"10.1093\/hropen\/hox008","article-title":"The sixth vital sign: what reproduction tells us about overall health. Proceedings from a NICHD\/CDC workshop","volume":"2017","author":"Cedars","year":"2017","journal-title":"Hum Reprod Open"},{"key":"2025100301515625400_deaf150-B13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.21037\/tau.2019.05.09","article-title":"Fertility concerns of the transgender patient","volume":"8","author":"Cheng","year":"2019","journal-title":"Transl Androl Urol"},{"key":"2025100301515625400_deaf150-B14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41594-023-01153-x","article-title":"Structural basis of the subcortical maternal complex and its implications in reproductive disorders","volume":"31","author":"Chi","year":"2024","journal-title":"Nat Struct Mol Biol"},{"key":"2025100301515625400_deaf150-B15","volume-title":"A Preconception Care Strategy","author":"Children\u2019s Alliance","year":"2023"},{"key":"2025100301515625400_deaf150-B16","doi-asserted-by":"crossref","first-page":"hoad023","DOI":"10.1093\/hropen\/hoad023","article-title":"ESHRE good practice recommendations on recurrent implantation failure","volume":"2023","author":"Cimadomo","year":"2023","journal-title":"Hum Reprod Open"},{"key":"2025100301515625400_deaf150-B17","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/humupd\/dmad010","article-title":"Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis","volume":"29","author":"Cimadomo","year":"2023","journal-title":"Hum Reprod Update"},{"key":"2025100301515625400_deaf150-B18","first-page":"24","article-title":"The impact of infertility on daily occupations and roles","volume":"20","author":"Collins","year":"2019","journal-title":"J Reprod Infertil"},{"key":"2025100301515625400_deaf150-B19","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/andr.12502","article-title":"European Academy of Andrology guideline management of oligo-astheno-teratozoospermia","volume":"6","author":"Colpi","year":"2018","journal-title":"Andrology"},{"key":"2025100301515625400_deaf150-B20","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0140-6736(21)00681-4","article-title":"Recurrent miscarriage: evidence to accelerate action","volume":"397","author":"Coomarasamy","year":"2021","journal-title":"Lancet"},{"key":"2025100301515625400_deaf150-B21","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/S0140-6736(21)00683-8","article-title":"Sporadic miscarriage: evidence to provide effective care","volume":"397","author":"Coomarasamy","year":"2021","journal-title":"Lancet"},{"key":"2025100301515625400_deaf150-B22","doi-asserted-by":"crossref","first-page":"hoac051","DOI":"10.1093\/hropen\/hoac051","article-title":"Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis","volume":"2022","author":"Cox","year":"2022","journal-title":"Hum Reprod Open"},{"key":"2025100301515625400_deaf150-B23","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/14647273.2017.1339127","article-title":"Direct-to-consumer DNA testing: the fallout for individuals and their families unexpectedly learning of their donor conception origins","volume":"21","author":"Crawshaw","year":"2018","journal-title":"Hum Fertil"},{"key":"2025100301515625400_deaf150-B24","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s40273-022-01211-0","article-title":"Economic implications of endometriosis: a review","volume":"40","author":"Darb\u00e0","year":"2022","journal-title":"Pharmacoeconomics"},{"key":"2025100301515625400_deaf150-B25","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1056\/NEJMc2211539","article-title":"Unexplained female infertility associated with genetic disease variants","volume":"388","author":"Dougherty","year":"2023","journal-title":"New Engl J Med"},{"key":"2025100301515625400_deaf150-B26","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1093\/humrep\/deaa242","article-title":"Top 10 priorities for future infertility research: an international consensus development study","volume":"35","author":"Duffy","year":"2020","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B27","author":"ECDC","year":"2024"},{"key":"2025100301515625400_deaf150-B28","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0140-6736(21)01743-8","article-title":"Addressing inequality in fertility treatment","volume":"398","author":"Ekechi","year":"2021","journal-title":"Lancet"},{"key":"2025100301515625400_deaf150-B29","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/GCO.0000000000000798","article-title":"Endometriosis biomarkers of the disease: an update","volume":"34","author":"Encalada Soto","year":"2022","journal-title":"Curr Opin Obstet Gynecol"},{"key":"2025100301515625400_deaf150-B30","author":"ESHRE","year":"2024"},{"key":"2025100301515625400_deaf150-B31","author":"European Commission","year":"2024"},{"key":"2025100301515625400_deaf150-B32","doi-asserted-by":"crossref","first-page":"25373","DOI":"10.18632\/aging.104141","article-title":"Effect of paternal age on offspring birth defects: a systematic review and meta-analysis","volume":"12","author":"Fang","year":"2020","journal-title":"Aging"},{"key":"2025100301515625400_deaf150-B33","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/ije\/dyv028","article-title":"Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort","volume":"44","author":"Feinberg","year":"2015","journal-title":"Int J Epidemiol"},{"key":"2025100301515625400_deaf150-B34","doi-asserted-by":"crossref","first-page":"103842","DOI":"10.1016\/j.rbmo.2024.103842","article-title":"An artificial intelligence tool predicts blastocyst development from static images of fresh mature oocytes","volume":"48","author":"Fjeldstad","year":"2024","journal-title":"Reprod Biomed Online"},{"key":"2025100301515625400_deaf150-B35","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/humrep\/dev177","article-title":"ESHRE guideline: routine psychosocial care in infertility and medically assisted reproduction-a guide for fertility staff","volume":"30","author":"Gameiro","year":"2015","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B36","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/humupd\/dmx001","article-title":"Long-term adjustment to unmet parenthood goals following ART: a systematic review and meta-analysis","volume":"23","author":"Gameiro","year":"2017","journal-title":"Hum Reprod Update"},{"key":"2025100301515625400_deaf150-B37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1056\/NEJMc1804810","article-title":"National Longitudinal Lesbian Family Study\u2014mental health of adult offspring","volume":"379","author":"Gartrell","year":"2018","journal-title":"New Engl J Med"},{"key":"2025100301515625400_deaf150-B38","doi-asserted-by":"crossref","first-page":"103421","DOI":"10.1016\/j.rbmo.2023.103421","article-title":"Direct-to-consumer genetic testing and the changing landscape of gamete donor conception: key issues for practitioners and stakeholders","volume":"48","author":"Gilman","year":"2024","journal-title":"Reprod Biomed Online"},{"key":"2025100301515625400_deaf150-B39","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/cdev.12728","article-title":"Parenting and the adjustment of children born to gay fathers through surrogacy","volume":"89","author":"Golombok","year":"2018","journal-title":"Child Dev"},{"key":"2025100301515625400_deaf150-B40","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1037\/fam0000188","article-title":"Single mothers by choice: mother\u2013child relationships and children\u2019s psychological adjustment","volume":"30","author":"Golombok","year":"2016","journal-title":"J Fam Psychol"},{"key":"2025100301515625400_deaf150-B41","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.fertnstert.2023.05.148","article-title":"Applications of artificial intelligence in ovarian stimulation: a tool for improving efficiency and outcomes","volume":"120","author":"Hariton","year":"2023","journal-title":"Fertil Steril"},{"key":"2025100301515625400_deaf150-B42","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/35066065","article-title":"To err (meiotically) is human: the genesis of human aneuploidy","volume":"2","author":"Hassold","year":"2001","journal-title":"Nat Rev Genet"},{"key":"2025100301515625400_deaf150-B43","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/S0140-6736(17)31344-2","article-title":"Top ten endometriosis research priorities in the UK and Ireland","volume":"389","author":"Horne","year":"2017","journal-title":"Lancet"},{"key":"2025100301515625400_deaf150-B44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.rbms.2021.07.003","article-title":"The missed disease? Endometriosis as an example of \u2018undone science\u2019","volume":"14","author":"Hudson","year":"2022","journal-title":"Reprod Biomed Soc Online"},{"key":"2025100301515625400_deaf150-B45","doi-asserted-by":"crossref","first-page":"212.e1","DOI":"10.1016\/j.ajog.2015.09.002","article-title":"Influence of race and ethnicity on in vitro fertilization outcomes: systematic review","volume":"214","author":"Humphries","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"2025100301515625400_deaf150-B46","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/humupd\/dmv016","article-title":"Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century","volume":"21","author":"Inhorn","year":"2015","journal-title":"Hum Reprod Update"},{"key":"2025100301515625400_deaf150-B47","author":"International Infertility Counselling Organisation","year":"2024"},{"key":"2025100301515625400_deaf150-B48","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.rbmo.2020.07.005","article-title":"Empathetic application of machine learning may address appropriate utilization of ART","volume":"41","author":"Jenkins","year":"2020","journal-title":"Reprod Biomed Online"},{"key":"2025100301515625400_deaf150-B49","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.fertnstert.2020.01.002","article-title":"New insights to guide patient care: the bidirectional relationship between male infertility and male health","volume":"113","author":"Kasman","year":"2020","journal-title":"Fertil Steril"},{"key":"2025100301515625400_deaf150-B50","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/S0015-0282(02)03454-4","article-title":"The social impact of infertility","volume":"78","author":"Katz","year":"2002","journal-title":"Fertil Steril"},{"key":"2025100301515625400_deaf150-B51","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1093\/humrep\/deab221","article-title":"Genetic incompatibility of the reproductive partners: an evolutionary perspective on infertility","volume":"36","author":"Kek\u00e4l\u00e4inen","year":"2021","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B52","doi-asserted-by":"crossref","first-page":"971553","DOI":"10.3389\/fgwh.2023.971553","article-title":"Does in vitro fertilization (IVF) treatment provide good value for money? A cost-benefit analysis","volume":"4","author":"Keller","year":"2023","journal-title":"Front Glob Womens Health"},{"key":"2025100301515625400_deaf150-B53","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/humrep\/deac077","article-title":"Where are we in understanding the natural history of polycystic ovary syndrome? A systematic review of longitudinal cohort studies","volume":"37","author":"Kiconco","year":"2022","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B54","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.fertnstert.2021.06.039","article-title":"Embryonic lethal genetic variants and chromosomally normal pregnancy loss","volume":"116","author":"Kline","year":"2021","journal-title":"Fertil Steril"},{"key":"2025100301515625400_deaf150-B55","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/15325024.2015.1057451","article-title":"Effects of a self-help program on depressed mood for women with an unfulfilled child wish","volume":"21","author":"Kraaij","year":"2016","journal-title":"J Loss Trauma"},{"key":"2025100301515625400_deaf150-B56","doi-asserted-by":"crossref","first-page":"102454","DOI":"10.1016\/j.bpobgyn.2023.102454","article-title":"Epidemiology of infertility in women with endometriosis","volume":"92","author":"Leone Roberti Maggiore","year":"2024","journal-title":"Best Pract Res Clin Obstetr Gynaecol"},{"key":"2025100301515625400_deaf150-B57","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/humupd\/dmac035","article-title":"Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries","volume":"29","author":"Levine","year":"2023","journal-title":"Hum Reprod Update"},{"key":"2025100301515625400_deaf150-B58","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/CM9.0000000000002861","article-title":"Associations between parental adherence to healthy lifestyles and cognitive performance in offspring: a prospective cohort study in China","volume":"137","author":"Lv","year":"2024","journal-title":"Chin Med J"},{"key":"2025100301515625400_deaf150-B59","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/humrep\/deac265","article-title":"#ESHREjc report: failed fertilization: is genetic incompatibility the elephant in the room?","volume":"38","author":"Makieva","year":"2023","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B60","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1186\/s12905-024-03369-5","article-title":"Understanding the impact of endometriosis on women\u2019s life: an integrative review of systematic reviews","volume":"24","author":"Maulenkul","year":"2024","journal-title":"BMC Women\u2019s Health"},{"key":"2025100301515625400_deaf150-B61","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/humrep\/dev336","article-title":"Cumulative live birth rates after one or more complete cycles of IVF: a population-based study of linked cycle data from 178,898 women","volume":"31","author":"McLernon","year":"2016","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B62","doi-asserted-by":"crossref","first-page":"e75061","DOI":"10.7554\/eLife.75061","article-title":"The need for more research into reproductive health and disease","volume":"11","author":"Mercuri","year":"2022","journal-title":"eLife"},{"key":"2025100301515625400_deaf150-B63","doi-asserted-by":"crossref","first-page":"e057132","DOI":"10.1136\/bmjopen-2021-057132","article-title":"Worldwide prevalence, risk factors and psychological impact of infertility among women: a systematic review and meta-analysis","volume":"12","author":"Nik Hazlina","year":"2022","journal-title":"BMJ Open"},{"key":"2025100301515625400_deaf150-B64","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3390\/diagnostics9040225","article-title":"Imaging modalities for diagnosis of deep pelvic endometriosis: comparison between trans-vaginal sonography, rectal endoscopy sonography and magnetic resonance imaging. A head-to-head meta-analysis","volume":"9","author":"Noventa","year":"2019","journal-title":"Diagnostics"},{"key":"2025100301515625400_deaf150-B65","volume-title":"Glossary of Key Terms in Evaluation and Results-Based Management for Sustainable Development","author":"OECD","year":"2023","edition":"2nd edn"},{"key":"2025100301515625400_deaf150-B66","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/03009734.2018.1480186","article-title":"What do people know about fertility? A systematic review on fertility awareness and its associated factors","volume":"123","author":"Pedro","year":"2018","journal-title":"Upsala J Med Sci"},{"key":"2025100301515625400_deaf150-B67","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s10815-022-02411-5","article-title":"Molecular tools for the genomic assessment of oocyte\u2019s reproductive competence","volume":"39","author":"Picchetta","year":"2022","journal-title":"J Assist Reprod Genet"},{"key":"2025100301515625400_deaf150-B68","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/humrep\/dez012","article-title":"Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy","volume":"34","author":"Popovic","year":"2019","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B69","doi-asserted-by":"crossref","first-page":"e016571","DOI":"10.1136\/bmjopen-2017-016571","article-title":"Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals following the James Lind Alliance methodology","volume":"7","author":"Prior","year":"2017","journal-title":"BMJ Open"},{"key":"2025100301515625400_deaf150-B70","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","article-title":"Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby","year":"2021","journal-title":"Lancet"},{"key":"2025100301515625400_deaf150-B71","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1210\/er.2012-1003","article-title":"Cardiometabolic aspects of the polycystic ovary syndrome","volume":"33","author":"Randeva","year":"2012","journal-title":"Endocr Rev"},{"key":"2025100301515625400_deaf150-B72","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10815-022-02689-5","article-title":"Endogenous progesterone in unexplained infertility: a systematic review and meta-analysis","volume":"40","author":"Raperport","year":"2023","journal-title":"J Assist Reprod Genet"},{"key":"2025100301515625400_deaf150-B73","first-page":"63","volume-title":"Embryo Models In Vitro: Methods and Protocols","author":"Rawlings","year":"2024"},{"key":"2025100301515625400_deaf150-B74","doi-asserted-by":"crossref","first-page":"79.e71","DOI":"10.1016\/j.ajog.2020.03.022","article-title":"Increasing NIH funding for academic departments of obstetrics and gynecology: a call to action","volume":"223","author":"Rice","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"2025100301515625400_deaf150-B75","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1093\/humrep\/deab168","article-title":"Artificial intelligence in the fertility clinic: status, pitfalls and possibilities","volume":"36","author":"Riegler","year":"2021","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B76","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1038\/s41556-023-01289-4","article-title":"Changing the public perception of human embryology","volume":"25","author":"Rivron","year":"2023","journal-title":"Nat Cell Biol"},{"key":"2025100301515625400_deaf150-B77","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.3390\/jcm10081650","article-title":"Hot topics on fertility preservation for women and girls\u2014current research, knowledge gaps, and future possibilities","volume":"10","author":"Rodriguez-Wallberg","year":"2021","journal-title":"J Clin Med"},{"key":"2025100301515625400_deaf150-B78","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/humrep\/dead150","article-title":"Evidence-based guideline: unexplained infertility","volume":"38","author":"Romualdi","year":"2023","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B79","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1093\/humrep\/deac168","article-title":"Feasibility randomized controlled trial of a self-guided online intervention to promote psychosocial adjustment to unmet parenthood goals","volume":"37","author":"Rowbottom","year":"2022","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B80","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ajhg.2018.02.015","article-title":"Homozygous mutations in WEE2 cause fertilization failure and female infertility","volume":"102","author":"Sang","year":"2018","journal-title":"Am J Hum Genet"},{"key":"2025100301515625400_deaf150-B81","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1038\/s41467-023-41656-1","article-title":"Decoding the endometrial niche of Asherman\u2019s syndrome at single-cell resolution","volume":"14","author":"Santamaria","year":"2023","journal-title":"Nat Commun"},{"key":"2025100301515625400_deaf150-B82","first-page":"CAT.22.0065","article-title":"The fast track to fertility program: rapid cycle innovation to redesign fertility care","volume":"3","author":"Senapati","year":"2022","journal-title":"NEJM Catal"},{"key":"2025100301515625400_deaf150-B83","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/humrep\/dead197","article-title":"ART in Europe, 2019: results generated from European registries by ESHRE","volume":"38","author":"Smeenk","year":"2023","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B84","author":"Sousa-Leite","year":"2024"},{"key":"2025100301515625400_deaf150-B85","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/1471-0528.14640","article-title":"Epidemiology of uterine fibroids: a systematic review","volume":"124","author":"Stewart","year":"2017","journal-title":"BJOG"},{"key":"2025100301515625400_deaf150-B86","doi-asserted-by":"crossref","first-page":"16043","DOI":"10.1038\/nrdp.2016.43","article-title":"Uterine fibroids","volume":"2","author":"Stewart","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2025100301515625400_deaf150-B87","doi-asserted-by":"crossref","first-page":"102927","DOI":"10.1016\/j.eclinm.2024.102927","article-title":"International PCOS guideline clinical research priorities roadmap: a co-designed approach aligned with end-user priorities in a neglected women\u2019s health condition","volume":"78","author":"Teede","year":"2024","journal-title":"EClinicalMedicine"},{"key":"2025100301515625400_deaf150-B88","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/humrep\/dead156","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"38","author":"Teede","year":"2023","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B89","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1038\/s41598-023-31136-3","article-title":"Development and validation of deep learning based embryo selection across multiple days of transfer","volume":"13","author":"Theilgaard Lassen","year":"2023","journal-title":"Sci Rep"},{"key":"2025100301515625400_deaf150-B90","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.fertnstert.2020.07.052","article-title":"A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing-based preimplantation genetic testing for aneuploidy assay and impact of biopsy","volume":"115","author":"Tiegs","year":"2021","journal-title":"Fertil Steril"},{"key":"2025100301515625400_deaf150-B91","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/humrep\/dez064","article-title":"Deep learning as a predictive tool for fetal heart pregnancy following time-lapse incubation and blastocyst transfer","volume":"34","author":"Tran","year":"2019","journal-title":"Hum Reprod (Oxford, England)"},{"key":"2025100301515625400_deaf150-B92","volume-title":"Transforming Our World: The 2030 Agenda for sustainable Development","author":"United Nations","year":"2015"},{"key":"2025100301515625400_deaf150-B93","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/humupd\/dmac044","article-title":"A systematic review and evidence assessment of monogenic gene-disease relationships in human female infertility and differences in sex development","volume":"29","author":"Van Der Kelen","year":"2023","journal-title":"Hum Reprod Update"},{"key":"2025100301515625400_deaf150-B94","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1093\/humrep\/deaa013","article-title":"Development of an artificial intelligence-based assessment model for prediction of embryo viability using static images captured by optical light microscopy during IVF","volume":"35","author":"VerMilyea","year":"2020","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B95","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1093\/humrep\/dead199","article-title":"Genetics of infertility: a paradigm shift for medically assisted reproduction","volume":"38","author":"Verpoest","year":"2023","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B96","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/s12905-021-01566-0","article-title":"Women empowerment in reproductive health: a systematic review of measurement properties","volume":"21","author":"Vizheh","year":"2021","journal-title":"BMC Women\u2019s Health"},{"key":"2025100301515625400_deaf150-B97","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1080\/09513590.2021.1916458","article-title":"Clinical exome sequencing identifies novel compound heterozygous mutations of the WEE2 gene in primary infertile women with fertilization failure","volume":"37","author":"Wang","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"2025100301515625400_deaf150-B98","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12978-022-01495-7","article-title":"A novel homozygous mutation in the PADI6 gene causes early embryo arrest","volume":"19","author":"Wang","year":"2022","journal-title":"Reprod Health"},{"key":"2025100301515625400_deaf150-B99","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/humrep\/deac058","article-title":"Sperm selection with hyaluronic acid improved live birth outcomes among older couples and was connected to sperm DNA quality, potentially affecting all treatment outcomes","volume":"37","author":"West","year":"2022","journal-title":"Hum Reprod (Oxford, England)"},{"key":"2025100301515625400_deaf150-B100","volume-title":"Preconception Care: Maximizing the Gains for Maternal and Child Health","author":"WHO","year":"2013"},{"key":"2025100301515625400_deaf150-B101","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"WHO","year":"2021"},{"key":"2025100301515625400_deaf150-B102","volume-title":"Polycystic Ovary Syndrome [Fact Sheet]","year":"2023"},{"key":"2025100301515625400_deaf150-B103","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.rbmo.2022.06.011","article-title":"Psychological adjustment in disclosing and non-disclosing heterosexual-couple families following conception with oocytes or spermatozoa from identity-release donors","volume":"45","author":"Widbom","year":"2022","journal-title":"Reprod Biomed Online"},{"key":"2025100301515625400_deaf150-B104","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13048-022-00971-9","article-title":"Mutation analysis of the TUBB8 gene in primary infertile women with oocyte maturation arrest","volume":"15","author":"Yao","year":"2022","journal-title":"J Ovarian Res"},{"key":"2025100301515625400_deaf150-B105","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1093\/humrep\/dey088","article-title":"The perspectives of adolescents conceived using surrogacy, egg or sperm donation","volume":"33","author":"Zadeh","year":"2018","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B106","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1093\/humrep\/dex234","article-title":"The international glossary on infertility and fertility care, 2017","volume":"32","author":"Zegers-Hochschild","year":"2017","journal-title":"Hum Reprod"},{"key":"2025100301515625400_deaf150-B107","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1186\/s12967-023-04610-9","article-title":"CRISPR\/Cas9 technology: applications in oocytes and early embryos","volume":"21","author":"Zhang","year":"2023","journal-title":"J Transl Med"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/10\/1829\/64014619\/deaf150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/10\/1829\/64014619\/deaf150.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T05:52:18Z","timestamp":1759470738000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/40\/10\/1829\/8231031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":107,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,8,11]]},"published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaf150","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,8,11]]}}}