{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:08:23Z","timestamp":1767092903803},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["UIDB 50006\/2020","SFRH\/BD\/145654\/2019"],"award-info":[{"award-number":["UIDB 50006\/2020","SFRH\/BD\/145654\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Angiotensin-converting enzyme 2 (ACE2) has been highlighted for its role as a receptor for SARS-CoV-2, responsible for the current COVID-19 pandemic. This review summarizes current knowledge about ACE2 as a multifunctional protein, focusing on its relevance in inflammatory bowel disease (IBD). As an enzyme, ACE2 may be protective in IBD because it favors the counter-regulatory arm of the renin-angiotensin system or deleterious because it metabolizes other anti-inflammatory\/repairing elements. Meanwhile, as a receptor for SARS-CoV-2, the impact of ACE2 expression\/activity on infection is still under debate because no direct evidence has been reported and, again, both protective and deleterious pathways are possible. Research has shown that ACE2 regulates the expression of the neutral amino acid transporter B0AT1, controlling tryptophan-associated intestinal inflammation and nutritional status. Finally, intact membrane-bound or shed soluble ACE2 can also trigger integrin signaling, modulating the response to anti-integrin biologic drugs used to treat IBD (such as vedolizumab) and fibrosis, a long-term complication of IBD. As such, future studies on ACE2 expression\/activity in IBD can improve monitoring of the disease and explore an alternative pharmacological target.<\/jats:p>","DOI":"10.1093\/ibd\/izaa249","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T13:35:58Z","timestamp":1602855358000},"page":"1787-1795","source":"Crossref","is-referenced-by-count":22,"title":["Unraveling the Role of ACE2, the Binding Receptor for SARS-CoV-2, in Inflammatory Bowel Disease"],"prefix":"10.1093","volume":"26","author":[{"given":"Mariana","family":"Ferreira-Duarte","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto , Porto, Portugal"},{"name":"LAQV@REQUIMTE, University of Porto , Porto, Portugal"}]},{"given":"Maria Manuela","family":"Estevinho","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto , Porto, Portugal"},{"name":"Department of Gastroenterology, Centro Hospitalar Vila Nova de Gaia\/Espinho , Vila Nova de Gaia, Portugal"}]},{"given":"Margarida","family":"Duarte-Ara\u00fajo","sequence":"additional","affiliation":[{"name":"LAQV@REQUIMTE, University of Porto , Porto, Portugal"},{"name":"Department of Immuno-Physiology and Pharmacology, ICBAS-UP , Porto, Portugal"}]},{"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto , Porto, Portugal"},{"name":"Department of Gastroenterology, Centro Hospitalar S\u00e3o Jo\u00e3o , Porto, Portugal"},{"name":"MedInUP, Center for Drug Discovery and Innovative Medicines , Porto, Portugal"}]},{"given":"Manuela","family":"Morato","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto , Porto, Portugal"},{"name":"LAQV@REQUIMTE, University of Porto , Porto, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"2022092715490741600_CIT0001","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet."},{"key":"2022092715490741600_CIT0002","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1146\/annurev-immunol-030409-101225","article-title":"Inflammatory bowel disease","volume":"28","author":"Kaser","year":"2010","journal-title":"Annu Rev Immunol."},{"key":"2022092715490741600_CIT0003","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.yexcr.2012.02.023","article-title":"Recent advances involving the renin-angiotensin system","volume":"318","author":"Crowley","year":"2012","journal-title":"Exp Cell Res."},{"key":"2022092715490741600_CIT0004","doi-asserted-by":"crossref","first-page":"16518","DOI":"10.1016\/S0021-9258(19)84737-3","article-title":"Identification of angiotensin-(1-7) in rat brain. 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