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Inflammation is a driving factor both in inflammatory bowel disease and cancer, but the mechanism underlying the transition from colon inflammation to cancer remains to be defined. Dysregulation of mucosal glycosylation has been described as a key regulatory mechanism associated both with colon inflammation and colorectal cancer development. In this review, we discuss the major molecular mechanisms of colitis-associated cancer pathogenesis, highlighting the role of glycans expressed at gut epithelial cells, at lamina propria T cells, and in serum proteins in the regulation of intestinal inflammation and its progression to colon cancer, further discussing its potential clinical and therapeutic applications.<\/jats:p>","DOI":"10.1093\/ibd\/izab291","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T14:09:08Z","timestamp":1638367748000},"page":"947-962","source":"Crossref","is-referenced-by-count":9,"title":["Bringing to Light the Risk of Colorectal Cancer in Inflammatory Bowel Disease: Mucosal Glycosylation as a Key Player"],"prefix":"10.1093","volume":"28","author":[{"given":"Eduarda","family":"Leite-Gomes","sequence":"first","affiliation":[{"name":"i3S-Institute for Research and Innovation in Health, University of Porto , Porto , Portugal"}]},{"given":"Ana 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Porto , Porto , Portugal"}]},{"given":"Rita","family":"Amorim","sequence":"additional","affiliation":[{"name":"i3S-Institute for Research and Innovation in Health, University of Porto , Porto , Portugal"},{"name":"Pediatrics Department, Centro Hospitalar e Universit\u00e1rio S\u00e3o Jo\u00e3o , Porto , Portugal"},{"name":"Medical Faculty, University of Porto , Porto , Portugal"}]},{"given":"Paula","family":"Lago","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar e Universit\u00e1rio do Porto , Porto , Portugal"}]},{"given":"Ricardo","family":"Marcos-Pinto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Centro Hospitalar e Universit\u00e1rio do Porto , Porto , Portugal"},{"name":"School of Medicine and Biomedical Sciences, University of Porto , Porto , Portugal"},{"name":"Centre for Research in Health Technologies and Information Systems, University of Porto , Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3484-5162","authenticated-orcid":false,"given":"Salom\u00e9 S","family":"Pinho","sequence":"additional","affiliation":[{"name":"i3S-Institute for Research and Innovation in Health, University of Porto , Porto , Portugal"},{"name":"School of Medicine and Biomedical Sciences, University of Porto , Porto , Portugal"},{"name":"Medical Faculty, University of Porto , Porto , Portugal"}]}],"member":"286","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"2022092301474893900_CIT0001","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrgastro.2017.1","article-title":"Clonal evolution of colorectal cancer in IBD.","volume":"14","author":"Choi","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"2022092301474893900_CIT0002","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next 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