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Although poorly studied, paracoccin (PCN) from Paracoccidioides brasiliensis has been shown to harbor lectinic, enzymatic, and immunomodulatory properties that affect disease development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mutants of P. brasiliensis overexpressing PCN (ov-PCN) were constructed by Agrobacterium tumefaciens\u2013mediated transformation. ov-PCN strains were analyzed and inoculated intranasally or intravenously to mice. Fungal burden, lung pathology, and survival were monitored to evaluate virulence. Electron microscopy was used to evaluate the size of chito-oligomer particles released by ov-PCN or wild-type strains to growth media.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ov-PCN strains revealed no differences in cell growth and viability, although PCN overexpression favored cell separation, chitin processing that results in the release of smaller chito-oligomer particles, and enhanced virulence. Our data show that PCN triggers a critical effect in the cell wall biogenesis through the chitinase activity resulting from overexpression of PCN. As such, PCN overexpression aggravates the disease caused by P. brasiliensis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data are consistent with a model in which PCN modulates the cell wall architecture via its chitinase activity. These findings highlight the potential for exploiting PCN function in future therapeutic approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiaa707","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T23:19:55Z","timestamp":1605223195000},"page":"164-174","source":"Crossref","is-referenced-by-count":6,"title":["Paracoccin Overexpression in\n                    <i>Paracoccidioides brasiliensis<\/i>\n                    Enhances Fungal Virulence by Remodeling Chitin Properties of the Cell Wall"],"prefix":"10.1093","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3037-3663","authenticated-orcid":false,"given":"Relber Aguiar","family":"Gon\u00e7ales","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ribeir\u00e3o Preto\/S\u00e3o Paulo,","place":["Brazil"]},{"name":"Life and Health Sciences Research Institute School of Medicine, University of Minho , Braga,","place":["Portugal"]},{"name":"ICVS\/3B\u2019s\u2013PT Government Associate Laboratory , Braga\/Guimar\u00e3es,","place":["Portugal"]}]},{"given":"Rafael","family":"Ricci-Azevedo","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ribeir\u00e3o Preto\/S\u00e3o Paulo,","place":["Brazil"]}]},{"given":"Vanessa C S","family":"Vieira","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute School of Medicine, University of Minho , Braga,","place":["Portugal"]}]},{"given":"Fabr\u00edcio F","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ribeir\u00e3o Preto\/S\u00e3o Paulo,","place":["Brazil"]}]},{"given":"Sandra M de O","family":"Thomaz","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ribeir\u00e3o Preto\/S\u00e3o Paulo,","place":["Brazil"]}]},{"given":"Agostinho","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute School of Medicine, University of Minho , Braga,","place":["Portugal"]},{"name":"ICVS\/3B\u2019s\u2013PT Government Associate Laboratory , Braga\/Guimar\u00e3es,","place":["Portugal"]}]},{"given":"Patr\u00edcia E","family":"Vendruscolo","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo , Ribeir\u00e3o Preto\/S\u00e3o 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