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We hypothesized that the extracellular matrix (ECM) could be involved in these deleterious effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Microarrays were used to uncover ECM interactors in cells infected with H. pylori. LAMC2, encoding laminin \u03b32, was selected as a candidate gene and its expression was assessed in vitro and in vivo. The role of LAMC2 was investigated by small interference RNA (siRNA) combined with a set of functional assays. Laminin \u03b32 and E-cadherin expression patterns were evaluated in gastric cancer cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Laminin \u03b32 was found significantly overexpressed in gastric cancer cells infected with H. pylori. This finding was validated in vitro by infection with clinical isolates and in vivo by using gastric biopsies of infected and noninfected individuals. We showed that laminin \u03b32 overexpression is dependent on the bacterial type IV secretion system and on the CagA. Functionally, laminin \u03b32 promotes cell invasion and resistance to apoptosis, through modulation of Src, JNK, and AKT activity. These effects were abrogated in cells with functional E-cadherin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data highlight laminin \u03b32 and its downstream effectors as potential therapeutic targets, and the value of H. pylori eradication to delay gastric cancer onset and progression.<\/jats:p><\/jats:sec>","DOI":"10.1093\/infdis\/jiac397","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T17:39:49Z","timestamp":1664473189000},"page":"2226-2237","source":"Crossref","is-referenced-by-count":10,"title":["Activation of Laminin \u03b32 by<i>Helicobacter pylori<\/i>Promotes Invasion and Survival of Gastric Cancer Cells With E-Cadherin Defects"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0961-2356","authenticated-orcid":false,"given":"Rui M","family":"Ferreira","sequence":"first","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, 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Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3377-0530","authenticated-orcid":false,"given":"Irene","family":"Gullo","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , Porto , Portugal"},{"name":"Institute of Molecular Pathology and Immunology of the University of Porto , Porto , Portugal"},{"name":"Department of Pathology, Faculty of Medicine, University of Porto , Porto , Portugal"},{"name":"Department of Pathology, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o , Porto , Portugal"}]},{"given":"Dionyssios N","family":"Sgouras","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Microbiology, Hellenic Pasteur Institute , Athens , Greece"}]},{"given":"Laura","family":"Carreto","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Aveiro , Aveiro , Portugal"},{"name":"Centre of Environmental and Marine Studies, University of 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