{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:39:23Z","timestamp":1772138363863,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Portuguese Foundation for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009091","name":"FCT","doi-asserted-by":"publisher","award":["2020.05949.BD"],"award-info":[{"award-number":["2020.05949.BD"]}],"id":[{"id":"10.13039\/501100009091","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Federation of Immunological Scientists-Immunology Letters"},{"DOI":"10.13039\/501100001704","name":"European Society of Clinical Microbiology and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007889","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007889","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The diversity of Mycobacterium tuberculosis impacts the outcome of tuberculosis. We previously showed that M. tuberculosis isolates obtained from patients with severe disease induced low inflammasome activation and interleukin 1\u03b2 (IL-1\u03b2) production by infected macrophages. Here we questioned whether this differential modulation of macrophages by M. tuberculosis isolates depended on distinct metabolic reprogramming. We found that the macrophage metabolic landscape was similar regardless of the infecting M. tuberculosis isolate. Paralleling single\u2013Toll-like receptor (TLR) activated macrophages, glycolysis inhibition during infection impaired IL-1\u03b2 secretion. However, departing from TLR -based models, in infected macrophages, IL-1\u03b2 secretion was independent of mitochondrial metabolic changes and hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1). Additionally, we found an unappreciated impact of a host metabolic inhibitor on the pathogen, and show that inflammasome activation and IL-1\u03b2 production by macrophages require metabolically active bacteria. Our study highlights the potential confounding effect of host metabolic inhibitors on the pathogen and uncoupling of M. tuberculosis-inflammasome modulation from the host metabolic reprogramming.<\/jats:p>","DOI":"10.1093\/infdis\/jiae583","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T15:23:26Z","timestamp":1732029806000},"page":"e671-e684","source":"Crossref","is-referenced-by-count":2,"title":["Genetically Diverse\n                    <i>Mycobacterium tuberculosis<\/i>\n                    Isolates Manipulate Inflammasome and Interleukin 1\u03b2 Secretion Independently of Macrophage Metabolic Rewiring"],"prefix":"10.1093","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-4303","authenticated-orcid":false,"given":"Ana Isabel","family":"Fernandes","sequence":"first","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , Porto ,","place":["Portugal"]},{"name":"Doctoral Program in Molecular and Cell Biology, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto , Porto ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-8145","authenticated-orcid":false,"given":"Alexandre Jorge","family":"Pinto","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , Porto ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2254-1230","authenticated-orcid":false,"given":"Diogo","family":"Silv\u00e9rio","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , Porto ,","place":["Portugal"]},{"name":"Doctoral Program in Molecular and Cell Biology, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto , Porto ,","place":["Portugal"]}]},{"given":"Ulrike","family":"Zedler","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Friedrich-Loeffler-Institut , Greifswald-Insel Riems ,","place":["Germany"]}]},{"given":"Carolina","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho , Braga ,","place":["Portugal"]},{"name":"ICVS\/3B's-PT Government Associate Laboratory , Braga ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-9256","authenticated-orcid":false,"given":"Iola F","family":"Duarte","sequence":"additional","affiliation":[{"name":"CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro , Aveiro ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9270-2717","authenticated-orcid":false,"given":"Ricardo","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho , Braga ,","place":["Portugal"]},{"name":"ICVS\/3B's-PT Government Associate Laboratory , Braga ,","place":["Portugal"]}]},{"given":"Anca","family":"Dorhoi","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Friedrich-Loeffler-Institut , Greifswald-Insel Riems ,","place":["Germany"]},{"name":"Faculty of Mathematics and Natural Sciences, University of Greifswald , Greifswald ,","place":["Germany"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8180-1293","authenticated-orcid":false,"given":"Margarida","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto , Porto ,","place":["Portugal"]},{"name":"Instituto de Biologia Molecular e Celular, University of Porto , Porto 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