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Our capacity to understand and exploit these symbioses is commonly compromised by the microbes unculturability and consequent lack of genetic tools, an impediment of particular significance for symbioses of pest and vector species. Previous work had established that insecticide susceptibility of the economically important pest of rice, the brown planthopper Nilaparvata lugens, was higher in field-collected lineages that carry Ca. Arsenophonus nilaparvatae. We established Ca. A. nilaparvatae into cell-free culture and used this to establish the complete closed genome of the symbiont. We transformed the strain to express GFP and reintroduced it to N. lugens to track infection in vivo. The symbiont established vertical transmission, generating a discrete infection focus towards the posterior pole of each N. lugens oocyte. This infection focus was retained in early embryogenesis before transition to a diffuse somatic infection in late N. lugens embryos and nymphs. We additionally generated somatic infection in novel host species, but these did not establish vertical transmission. Transinfected planthopper lines acquired the insecticide sensitivity trait, with associated downregulation of the P450 xenobiotic detoxification system of the host. Our results causally establish the role of the symbiont in increasing host insecticide sensitivity with implications for insecticide use and stewardship. Furthermore, the culturability and transformation of this intracellular symbiont, combined with its ease of reintroduction to planthopper hosts, enables novel approaches both for research into symbiosis and into control of insect pest species.<\/jats:p>","DOI":"10.1093\/ismejo\/wrae194","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:54:11Z","timestamp":1728348851000},"source":"Crossref","is-referenced-by-count":20,"title":["Insecticide susceptibility in a planthopper pest increases following inoculation with cultured <i>Arsenophonus<\/i>"],"prefix":"10.1093","volume":"18","author":[{"given":"Tingwei","family":"Cai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University , Wuhan 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory , Wuhan 430070 ,","place":["China"]},{"name":"Department of Microbiology & Immunology, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]},{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]},{"name":"Huazhong Agricultural University , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]}]},{"given":"Pol","family":"Nadal-Jimenez","sequence":"additional","affiliation":[{"name":"Department of Vector Biology, Liverpool School of Tropical Medicine , Liverpool L3 5QA ,","place":["United Kingdom"]},{"name":"Institute of Infection , Veterinary and Ecological Sciences, , Liverpool L69 7ZB ,","place":["United Kingdom"]},{"name":"University of Liverpool , Veterinary and Ecological Sciences, , Liverpool L69 7ZB ,","place":["United Kingdom"]}]},{"given":"Yuanyuan","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University , Wuhan 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory , Wuhan 430070 ,","place":["China"]},{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]},{"name":"Huazhong Agricultural University , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]}]},{"given":"Hiroshi","family":"Arai","sequence":"additional","affiliation":[{"name":"Institute of Infection , Veterinary and Ecological Sciences, , Liverpool L69 7ZB ,","place":["United Kingdom"]},{"name":"University of Liverpool , Veterinary and Ecological Sciences, , Liverpool L69 7ZB ,","place":["United Kingdom"]}]},{"given":"Chengyue","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University , Wuhan 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory , Wuhan 430070 ,","place":["China"]},{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]},{"name":"Huazhong Agricultural University , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]}]},{"given":"Chunyan","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University , Wuhan 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory , Wuhan 430070 ,","place":["China"]},{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]},{"name":"Huazhong Agricultural University , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]}]},{"given":"Kayla C","family":"King","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, University of British Columbia , Vancouver, British Columbia V6T 1Z3 ,","place":["Canada"]}]},{"given":"Shun","family":"He","sequence":"additional","affiliation":[{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]},{"name":"Huazhong Agricultural University , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]}]},{"given":"Jianhong","family":"Li","sequence":"additional","affiliation":[{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]},{"name":"Huazhong Agricultural University , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]}]},{"given":"Gregory D D","family":"Hurst","sequence":"additional","affiliation":[{"name":"Institute of Infection , Veterinary and Ecological Sciences, , Liverpool L69 7ZB ,","place":["United Kingdom"]},{"name":"University of Liverpool , Veterinary and Ecological Sciences, , Liverpool L69 7ZB ,","place":["United Kingdom"]}]},{"given":"Hu","family":"Wan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University , Wuhan 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory , Wuhan 430070 ,","place":["China"]},{"name":"Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]},{"name":"Huazhong Agricultural University , College of Plant Science and Technology, , Wuhan 430070 ,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"2024102110240875100_ref1","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.1073\/pnas.1218525110","article-title":"Animals in a bacterial world, a new imperative for the life 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