{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:54:58Z","timestamp":1769766898015,"version":"3.49.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The objective of this study was to clarify the antifungal properties of cerium, a lanthanide member, against Candida species. A comprehensive study with planktonic and sessile cells was performed. The ability of cerium nitrate (CN) to impair in vitro and in vivo biofilm formation was evaluated and its potential use in biofilm treatment was also evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Forty-eight clinical isolates of different Candida species and the type strain ATCC 90028 were tested according to the protocol M27-A3. The MICs and minimum lethal concentrations were determined. A time\u2013kill assay was performed and a cytometric kinetic study was performed using live\/dead markers. Biofilm inhibition and biofilm susceptibility in the presence of cerium was evaluated by quantification of the biofilm metabolic activity and total biomass with XTT and crystal violet assays, respectively. CN in vivo efficacy as a coating for medical indwelling devices was evaluated for the first time for Candida parapsilosis, using a mouse subcutaneous foreign body model using polyurethane catheter segments. Scanning electron microscopy was used to assess biofilm architecture after CN treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The MICs for planktonic cells correlated with severe cellular metabolic activity impairment and membrane damage after 3 h of incubation. Moreover, CN efficiently prevented biofilm formation both in vitro and in vivo in segments of polyurethane catheters. At higher concentrations, it was also able to disorganize and almost eradicate preformed biofilms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results strongly suggest that CN application in the clinical setting might be effective in preventing the formation of biofilm-associated infections, namely through catheter coating and ultimately as an antimicrobial lock therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dku511","type":"journal-article","created":{"date-parts":[[2015,1,4]],"date-time":"2015-01-04T01:10:29Z","timestamp":1420333829000},"page":"1083-1093","source":"Crossref","is-referenced-by-count":21,"title":["<i>In vitro<\/i> antifungal activity and <i>in vivo<\/i> antibiofilm activity of cerium nitrate against <i>Candida<\/i> species"],"prefix":"10.1093","volume":"70","author":[{"given":"Ana","family":"Silva-Dias","sequence":"first","affiliation":[{"name":"1 \u00a0Department of Microbiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"2 \u00a0Cardiovascular Research & Development Unit, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"3 \u00a0CINTESIS, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Isabel M.","family":"Miranda","sequence":"additional","affiliation":[{"name":"1 \u00a0Department of Microbiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"2 \u00a0Cardiovascular Research & Development Unit, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"3 \u00a0CINTESIS, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Joana","family":"Branco","sequence":"additional","affiliation":[{"name":"1 \u00a0Department of Microbiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Lu\u00eds","family":"Cobrado","sequence":"additional","affiliation":[{"name":"1 \u00a0Department of Microbiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"2 \u00a0Cardiovascular Research & Development Unit, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"3 \u00a0CINTESIS, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"4 \u00a0Burn Unit and Department of Plastic and Reconstructive Surgery, Centro Hospitalar S. Jo\u00e3o, 4200-319 Porto, Portugal"}]},{"given":"Matilde","family":"Monteiro-Soares","sequence":"additional","affiliation":[{"name":"5 \u00a0CIDES, Department of Information and Decision Sciences in Health, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"}]},{"given":"Cid\u00e1lia","family":"Pina-Vaz","sequence":"additional","affiliation":[{"name":"1 \u00a0Department of Microbiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"2 \u00a0Cardiovascular Research & Development Unit, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"3 \u00a0CINTESIS, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"6 \u00a0Department of Microbiology, Centro Hospitalar S. Jo\u00e3o, 4200-319 Porto, Portugal"}]},{"given":"Ac\u00e1cio G.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"1 \u00a0Department of Microbiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"2 \u00a0Cardiovascular Research & Development Unit, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"3 \u00a0CINTESIS, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal"},{"name":"4 \u00a0Burn Unit and Department of Plastic and Reconstructive Surgery, Centro Hospitalar S. Jo\u00e3o, 4200-319 Porto, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2015,1,3]]},"reference":[{"key":"2022020120544646100_DKU511C1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1086\/376906","article-title":"A prospective observational study of candidemia: epidemiology, therapy, and influences on mortality in hospitalized adult and pediatric patients","volume":"37","author":"Pappas","year":"2003","journal-title":"Clin Infect Dis"},{"key":"2022020120544646100_DKU511C2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/CMR.00029-06","article-title":"Epidemiology of invasive candidiasis: a persistent public health problem","volume":"20","author":"Pfaller","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"2022020120544646100_DKU511C3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10096-002-0822-1","article-title":"Candidemia at a tertiary-care hospital: epidemiology, treatment, clinical outcome and risk factors 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