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In this study, two drugs (montelukast and cefoperazone) with well-established therapeutic applications were tested on Pseudomonas aeruginosa quorum sensing (QS) inhibition and biofilm control.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The activity of montelukast and cefoperazone was evaluated for Pqs signal inhibition, pyocyanin synthesis, and prevention and eradication of Ps. aeruginosa biofilms. Cefoperazone inhibited the Pqs system by hindering the production of the autoinducer molecules 2-heptyl-4-hydroxyquinoline (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (the Pseudomonas quinolone signal or PQS), corroborating in silico results. Pseudomonas aeruginosa pyocyanin production was reduced by 50%. The combination of the antibiotics cefoperazone and ciprofloxacin was synergistic for Ps. aeruginosa biofilm control. On the other hand, montelukast had no relevant effects on the inhibition of the Pqs system and against Ps. aeruginosa biofilm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study provides for the first time strong evidence that cefoperazone interacts with the Pqs system, hindering the formation of the autoinducer molecules HHQ and PQS, reducing Ps. aeruginosa pathogenicity and virulence. Cefoperazone demonstrated a potential to be used in combination with less effective antibiotics (e.g. ciprofloxacin) to potentiate the biofilm control action.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae088","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T17:24:40Z","timestamp":1712597080000},"source":"Crossref","is-referenced-by-count":7,"title":["Montelukast and cefoperazone act as antiquorum sensing and antibiofilm agents against <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1093","volume":"135","author":[{"given":"Tatiana F","family":"Vieira","sequence":"first","affiliation":[{"name":"Faculty of Medicine, LAQV\/REQUIMTE, BioSIM, Departamento de Medicina, University of Porto , Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto , Portugal"}]},{"given":"Miguel M","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, LEPABE Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto , Rua Dr Roberto Frias, s\/n, 4200-465 Porto , Portugal"},{"name":"Faculty of Engineering, ALiCE \u2013 Associate Laboratory in Chemical Engineering, University of Porto , Rua Dr Roberto Frias, 4200-465 Porto , Portugal"},{"name":"Faculty of Sciences, CIQUP-IMS \u2013 Department of Chemistry and Biochemistry, University of Porto , Rua Campo Alegre 687, 4169-007 Porto , Portugal"}]},{"given":"Nuno M F S A","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, LAQV\/REQUIMTE, BioSIM, Departamento de Medicina, University of Porto , Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto , Portugal"}]},{"given":"S\u00e9rgio F","family":"Sousa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, LAQV\/REQUIMTE, BioSIM, Departamento de Medicina, University of Porto , Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto , 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