{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T18:17:45Z","timestamp":1777141065185,"version":"3.51.4"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Burn wound infections are often the source of bacteria responsible for systemic infections, including bloodstream infections and pneumonia that ultimately can result in multisystem organ failure and death. Any rapid change in the burn wound appearance or the clinical condition of the burn patient may herald burn wound infection or sepsis. The revival of phage therapy, either in single mode or in combination with conventional antibiotics may represent a valuable alternative, to treat specific bacterial infections such as burn wound infections, including those caused by multidrug-resistant organisms. This systematic review addresses the: 1) general characteristics of bacteriophages; 2) activity of bacteriophages vs conventional antibiotics; 3) activity of bacteriophages against biofilms; 4) bacteriophage administration; and 5) use of bacteriophages in burn wound infections. Although several scientific organizations\/societies recognized that phage therapy could be of key value in modern wound care, specific aspects are critical for a burn surgeon and might represent pitfalls discouraging phage therapy adoption in burn wound management; in particular, the unavailability of consensual therapeutic guidelines\/regulatory policies and the lack of laboratorial support that might be predictive of its efficacy. The availability of a product\/formulation convenient to use, with adequate stability and shelf half-life is also a key condition.<\/jats:p>","DOI":"10.1093\/jbcr\/irab175","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T12:04:56Z","timestamp":1631707496000},"page":"336-342","source":"Crossref","is-referenced-by-count":22,"title":["The Role of Phage Therapy in Burn Wound Infections Management: Advantages and Pitfalls"],"prefix":"10.1093","volume":"43","author":[{"given":"Maria Manuel","family":"Azevedo","sequence":"first","affiliation":[{"name":"Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto"},{"name":"CINTESIS - Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto"}]},{"given":"Cid\u00e1lia","family":"Pina-Vaz","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto"},{"name":"CINTESIS - Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto"}]},{"given":"Ac\u00e1cio G","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto"},{"name":"CINTESIS - Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto"},{"name":"Burn Unit, Department of Plastic and Reconstructive Surgery, University Hospital S\u00e3o Jo\u00e3o, Porto"}]}],"member":"286","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"2022032516094545100_CIT0001","volume-title":"Brock biology of microorganisms","author":"Madigan","year":"2012","edition":"13"},{"key":"2022032516094545100_CIT0002","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/21119","article-title":"Marine viruses and their biogeochemical and ecological 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