{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:22:05Z","timestamp":1768011725895,"version":"3.49.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp & Dohme","doi-asserted-by":"publisher","award":["MISP 42521"],"award-info":[{"award-number":["MISP 42521"]}],"id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biobanco-iMM"},{"name":"Lisbon Academic Medical Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Risk factors for the development of severe COVID-19 include several comorbidities, but age was the most striking one since elderly people were disproportionately affected by SARS-CoV-2 infection. Among the reasons for this markedly unfavorable response in the elderly, immunosenescence and inflammaging appear as major drivers of this outcome. A finding that was also notable was that hospitalized patients with severe COVID-19 have an accumulation of senescent T cells, suggesting that immunosenescence may be aggravated by SARS-CoV-2 infection. The present work was designed to examine whether these immunosenescence changes are characteristic of COVID-19 and whether it is dependent on disease severity using cross-sectional and longitudinal studies. Our cross-sectional data show that COVID-19, but not other respiratory infections, rapidly increased cellular senescence and exhaustion in CD4 and CD8 T cells during early infection. In addition, longitudinal analyses with patients from Brazil and Portugal provided evidence of increased frequencies of senescent and exhausted T cells over a 7-d period in patients with mild\/moderate and severe COVID-19. Altogether, the study suggests that accelerated immunosenescence in CD4 and especially CD8 T-cell compartments may represent a common and unique outcome of SARS-CoV2 infection.<\/jats:p>","DOI":"10.1093\/jleuko\/qiae180","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T16:34:53Z","timestamp":1726763693000},"page":"1385-1397","source":"Crossref","is-referenced-by-count":6,"title":["Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection"],"prefix":"10.1093","volume":"116","author":[{"given":"Rodrigo Balsinha","family":"Pedroso","sequence":"first","affiliation":[{"name":"Faculdade de Medicina, Instituto de Medicina Molecular, Universidade de Lisboa , Av. 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Antonio Carlos, 6627, 31270-901, Belo Horizonte, MG ,","place":["Brazil"]}]},{"given":"Giovanna Caliman","family":"Camatta","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas (ICB), Universidade Federal de Minas Gerais (UFMG) , Av. Antonio Carlos, 6627, 31270-901, Belo Horizonte, MG ,","place":["Brazil"]}]},{"given":"Catarina","family":"Mota","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Instituto de Medicina Molecular, Universidade de Lisboa , Av. Prof. Egas Moniz, 1649, 1649-028, Lisboa ,","place":["Portugal"]}]},{"given":"Ana Catarina","family":"Mendes","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Instituto de Medicina Molecular, Universidade de Lisboa , Av. 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Antonio Carlos, 6627, 31270-901, Belo Horizonte, MG ,","place":["Brazil"]}]},{"given":"Gabriela","family":"Silveira-Nunes","sequence":"additional","affiliation":[{"name":"Departamento de Medicina, Universidade Federal de Juiz de Fora (UFJF) , Av. Doutor Raimundo Monteiro Resende, Governador Valadares, 35010-177, MG ,","place":["Brazil"]}]},{"given":"Una\u00ed","family":"Tupinamb\u00e1s","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica M\u00e9dica, Faculdade de Medicina, Universidade Federal de Minas Gerais , Av. Alfredo Balena, 190, Belo Horizonte, 30130-100, MG ,","place":["Brazil"]}]},{"given":"Andrea","family":"Teixeira-Carvalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biomarcadores, Instituto de Pesquisa Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, FIOCRUZ-MG , Av. 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