{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:58:52Z","timestamp":1764784732181,"version":"3.37.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/CTM CTM\/30949\/2017","SFRH\/BD\/146968\/2019"],"award-info":[{"award-number":["PTDC\/CTM CTM\/30949\/2017","SFRH\/BD\/146968\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The objective of this study was to develop a method for the preparation and characterization of paroxetine (PRX) tablets, obtained by coupling hot-melt extrusion and fused deposition modelling (FDM)-based three-dimensional printing (3DP) technology. The impact of the printing process parameters on the drug stability and on the tablets performance was assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Tablets were obtained by FDM of hot-melt extruded PRX-loaded filaments. Physicochemical, thermal, spectroscopic, diffractometric analysis and in-vitro dissolution tests of the intermediate products and the finished dosage forms were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The characterization of printed tablets evidenced mass and dimensions uniformity, and consistency of drug content and dissolution profile. The formation of amorphous solid dispersions and interaction of formulation components throughout the manufacturing process were demonstrated. Layer thickness, printing temperature, printing and travelling speeds, and infill were the most impacting process parameters on both the physicochemical properties and the in-vitro performance of the 3D-printed tablets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>PRX tablets, meeting compendial limits, were manufactured by 3DP, envisaging their clinical use as individually designed dosage forms. The assessment of the impact of processing parameters on the printed tablets provided insights, which will ultimately allow streamlining of the 3D process set-up for quicker and easier production of patient-centric medicines.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgab138","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:43:50Z","timestamp":1631101430000},"page":"67-76","source":"Crossref","is-referenced-by-count":11,"title":["Performance and paroxetine stability in tablets manufactured by fused deposition modelling-based 3D printing"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-0921","authenticated-orcid":false,"given":"Sara","family":"Figueiredo","sequence":"first","affiliation":[{"name":"iMed.ULisboa, Faculdade de Farm\u00e1cia da Universidade de Lisboa , Lisboa ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2705-4845","authenticated-orcid":false,"given":"Ana I","family":"Fernandes","sequence":"additional","affiliation":[{"name":"CiiEM, Instituto Universit\u00e1rio Egas Moniz , Caparica ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9317-316X","authenticated-orcid":false,"given":"F\u00e1tima G","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Infosa\u00fade \u2013 Laborat\u00f3rio de Estudos Farmac\u00eauticos , Barcarena ,","place":["Portugal"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6499-310X","authenticated-orcid":false,"given":"Jo\u00e3o F","family":"Pinto","sequence":"additional","affiliation":[{"name":"iMed.ULisboa, Faculdade de Farm\u00e1cia da Universidade de Lisboa , Lisboa ,","place":["Portugal"]}]}],"member":"286","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"2024103012162361500_CIT0001","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijpharm.2014.12.006","article-title":"Personalised dosing: printing a dose of one\u2019s own medicine","volume":"494","author":"Alomari","year":"2015","journal-title":"Int J Pharm"},{"key":"2024103012162361500_CIT0002","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.ijpharm.2015.04.069","article-title":"Effect of geometry on drug release from 3D printed tablets","volume":"494","author":"Goyanes","year":"2015","journal-title":"Int J Pharm"},{"key":"2024103012162361500_CIT0003","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ijpharm.2016.12.049","article-title":"Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets","volume":"519","author":"Zhang","year":"2017","journal-title":"Int J Pharm"},{"key":"2024103012162361500_CIT0004","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijpharm.2017.05.074","article-title":"3D printed tablets loaded with polymeric nanocapsules: an innovative approach to produce customized drug delivery systems","volume":"528","author":"Beck","year":"2017","journal-title":"Int J Pharm"},{"key":"2024103012162361500_CIT0005","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1517\/17425247.2013.859134","article-title":"Printing technologies in fabrication of drug delivery systems","volume":"10","author":"Kolakovic","year":"2013","journal-title":"Expert Opin Drug Deliv"},{"key":"2024103012162361500_CIT0006","doi-asserted-by":"crossref","first-page":"957","DOI":"10.4155\/tde-2017-0067","article-title":"FDM 3D printing of modified drug-delivery systems using hot melt extrusion: a new approach for individualized therapy","volume":"8","author":"Cunha-Filho","year":"2017","journal-title":"Ther Deliv"},{"key":"2024103012162361500_CIT0007","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3390\/pharmaceutics10040203","article-title":"Advanced pharmaceutical applications of hot-melt extrusion coupled with fused deposition modelling (FDM) 3D printing for personalised drug delivery","volume":"10","author":"Tan","year":"2018","journal-title":"Pharmaceutics"},{"key":"2024103012162361500_CIT0008","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejps.2013.10.014","article-title":"Evaluation of hot-melt extrusion technique in the preparation of HPC matrices for prolonged release","volume":"52","author":"Loreti","year":"2014","journal-title":"Eur J Pharm Sci"},{"key":"2024103012162361500_CIT0009","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s12247-009-9053-7","article-title":"Aqueous solubility enhancement through engineering of binary solid composites: pharmaceutical applications","volume":"4","author":"Moore","year":"2009","journal-title":"J Pharm Innov"},{"key":"2024103012162361500_CIT0010","doi-asserted-by":"crossref","first-page":"120237","DOI":"10.1016\/j.ijpharm.2021.120237","article-title":"A comprehensive overview of extended release oral dosage forms manufactured through hot melt extrusion and its combination with 3D printing","volume":"596","author":"Nashed","year":"2021","journal-title":"Int J Pharm"},{"key":"2024103012162361500_CIT0011","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1021\/mp3003573","article-title":"Identification and characterization of stoichiometric and non-stoichiometric hydrate forms of paroxetine HCL: reversible changes in crystal dimensions as a function of water absorption","volume":"9","author":"Pina","year":"2012","journal-title":"Mol Pharm"},{"key":"2024103012162361500_CIT0012","doi-asserted-by":"crossref","first-page":"22364","DOI":"10.3390\/molecules201219832","article-title":"Role of polymeric excipients in the stabilization of olanzapine when exposed to aqueous environments","volume":"20","author":"Paisana","year":"2015","journal-title":"Molecules"},{"key":"2024103012162361500_CIT0013","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2174\/1567201817999201110193655","article-title":"Hot melt extrusion and its application in 3D printing of pharmaceuticals","volume":"18","author":"Deshkar","year":"2021","journal-title":"Curr Drug Deliv"},{"key":"2024103012162361500_CIT0014","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3390\/pharmaceutics12090795","article-title":"Polymer selection for hot-melt extrusion coupled to fused deposition modelling in pharmaceutics","volume":"12","author":"Pereira","year":"2020","journal-title":"Pharmaceutics"},{"key":"2024103012162361500_CIT0015","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.addr.2021.02.006","article-title":"Coupling hot melt extrusion and fused deposition modeling: critical properties for successful performance","volume":"172","author":"Bandari","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"2024103012162361500_CIT0016","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ejpb.2015.07.027","article-title":"A flexible-dose dispenser for immediate and extended release 3D printed tablets","volume":"96","author":"Pietrzak","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"2024103012162361500_CIT0017","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jddst.2015.07.016","article-title":"3D printing by fused deposition modeling (FDM) of a swellable\/erodible capsular device for oral pulsatile release of drugs","volume":"30","author":"Melocchi","year":"2015","journal-title":"J Drug Deliv Sci Technol"},{"key":"2024103012162361500_CIT0018","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ijpharm.2016.05.036","article-title":"Hot-melt extruded filaments based on pharmaceutical grade polymers for 3D printing by fused deposition modeling","volume":"509","author":"Melocchi","year":"2016","journal-title":"Int J Pharm"},{"volume-title":"Mechanical Behaviour of Engineering Materials: Metals, Ceramics, Polymers, and Composites","year":"2007","author":"Ro\u0308sler","key":"2024103012162361500_CIT0019"},{"volume-title":"European Pharmacopoeia","year":"2008","author":"Council of Europe.","key":"2024103012162361500_CIT0020"},{"key":"2024103012162361500_CIT0021","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.aca.2006.03.036","article-title":"Near infrared spectroscopy in the study of polymorphic transformations","volume":"567","author":"Blanco","year":"2006","journal-title":"Anal Chim Acta"},{"key":"2024103012162361500_CIT0022","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1002\/jps.21717","article-title":"Novel methods for the assessment of miscibility of amorphous drug-polymer dispersions","volume":"98","author":"Ivanisevic","year":"2009","journal-title":"J Pharm Sci"},{"key":"2024103012162361500_CIT0023","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.powtec.2007.01.030","article-title":"Preparation of agglomerated crystals for improving flowability and compactibility of poorly flowable and compactible drugs and excipients","volume":"175","author":"Nokhodchi","year":"2007","journal-title":"Powder Technol"},{"key":"2024103012162361500_CIT0024","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1002\/jps.22233","article-title":"A solid-state approach to enable early development compounds: selection and animal bioavailability studies of an itraconazole amorphous solid dispersion","volume":"99","author":"Engers","year":"2010","journal-title":"J Pharm Sci"},{"key":"2024103012162361500_CIT0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1527-3458.2001.tb00189.x","article-title":"Paroxetine: a review","volume":"7","author":"Bourin","year":"2001","journal-title":"CNS Drug Rev"},{"key":"2024103012162361500_CIT0026","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0378-5173(88)90169-X","article-title":"Solid-state forms of paroxetine hydrochloride","volume":"42","author":"Buxton","year":"1988","journal-title":"Int J Pharm"},{"year":"1993","author":"U.S. Department of Health and Human Services, Food and Drug Administration.","key":"2024103012162361500_CIT0027"},{"key":"2024103012162361500_CIT0028","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3390\/pharmaceutics11120633","article-title":"Impact of processing parameters on the quality of pharmaceutical solid dosage forms produced by fused deposition modeling (FDM)","volume":"11","author":"Alhijjaj","year":"2019","journal-title":"Pharmaceutics"},{"key":"2024103012162361500_CIT0029","first-page":"100076","article-title":"Effect of process parameters on mechanical properties of 3D printed PLA lattice structures","volume":"3","author":"Tang","year":"2020","journal-title":"Compos Part C"},{"key":"2024103012162361500_CIT0030","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1021\/cg500150r","article-title":"An investigation into the dehydration behavior of paroxetine HCl form I using a combination of thermal and diffraction methods: the identification and characterization of a new anhydrous form","volume":"14","author":"Pina","year":"2014","journal-title":"Cryst Growth Des"},{"key":"2024103012162361500_CIT0031","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ijpharm.2018.07.001","article-title":"Deciphering magnesium stearate thermotropic behavior","volume":"548","author":"Haware","year":"2018","journal-title":"Int J Pharm"},{"key":"2024103012162361500_CIT0032","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.ejpb.2013.03.026","article-title":"Amino acids as coamorphous stabilizers for poorly water-soluble drugs\u2014Part 2: Molecular interactions","volume":"85","author":"L\u00f6bmann","year":"2013","journal-title":"Eur J Pharm Biopharm"},{"key":"2024103012162361500_CIT0033","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.apsb.2018.08.002","article-title":"Advances in co-amorphous drug delivery systems","volume":"B9","author":"Shi","year":"2019","journal-title":"Acta Pharm Sin B"},{"key":"2024103012162361500_CIT0034","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.molstruc.2010.12.020","article-title":"IR, Raman, SERS and DFT study of paroxetine","volume":"993","author":"Cozar","year":"2011","journal-title":"J Mol Struct"},{"key":"2024103012162361500_CIT0035","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1002\/jps.20697","article-title":"Influence of different polymers on the crystallization tendency of molecularly dispersed amorphous felodipine","volume":"95","author":"Konno","year":"2006","journal-title":"J Pharm Sci"},{"key":"2024103012162361500_CIT0036","first-page":"63","article-title":"Formulation and in vitro release kinetic study of an enteric coated paroxetine controlled release tablets","volume":"2014","author":"Thirumaran","journal-title":"Asian J Res Chem Pharm Sci"},{"key":"2024103012162361500_CIT0037","first-page":"243","article-title":"Development of paroxetine hydrochloride single layer controlled-release tablets based on factorial design","volume":"10","author":"Yang","year":"2018","journal-title":"Asian J Res Pharm"},{"key":"2024103012162361500_CIT0038","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1021\/mp034006h","article-title":"Molecular properties of WHO essential drugs and provisional biopharmaceutical classification","volume":"1","author":"Kasim","year":"2004","journal-title":"Mol Pharm"},{"key":"2024103012162361500_CIT0039","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijpharm.2016.10.021","article-title":"Dual release and molecular mechanism of bilayered aceclofenac tablet using polymer mixture","volume":"515","author":"Nguyen","year":"2016","journal-title":"Int J Pharm"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/74\/1\/67\/60218161\/rgab138.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/74\/1\/67\/60218161\/rgab138.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T16:56:58Z","timestamp":1730307418000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/74\/1\/67\/6378305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,1]]},"published-print":{"date-parts":[[2022,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgab138","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"type":"print","value":"0022-3573"},{"type":"electronic","value":"2042-7158"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2022,1,1]]}}}