{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:42:11Z","timestamp":1772574131420,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"crossref","award":["4093-00245B"],"award-info":[{"award-number":["4093-00245B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Portuguese Foundation for Science and Technology","award":["IF\/01641\/2014"],"award-info":[{"award-number":["IF\/01641\/2014"]}]},{"name":"Portuguese Foundation for Science and Technology","award":["IF\/01126\/2012"],"award-info":[{"award-number":["IF\/01126\/2012"]}]},{"name":"Research Unit-GREEN-IT","award":["UID\/Multi\/04551\/2013"],"award-info":[{"award-number":["UID\/Multi\/04551\/2013"]}]},{"name":"NORTE2020","award":["NORTE-01-0145-FEDER-000007"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000007"]}]},{"name":"ZonMWZenith program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The F-bZIP transcription factors bZIP19 and bZIP23 are the central regulators of the zinc deficiency response in Arabidopsis, and phylogenetic analysis of F-bZIP homologs across land plants indicates that the regulatory mechanism of the zinc deficiency response may be conserved. Here, we identified the rice F-bZIP homologs and investigated their function. OsbZIP48 and OsbZIP50, but not OsbZIP49, complement the zinc deficiency-hypersensitive Arabidopsis bzip19bzip23 double mutant. Ectopic expression of OsbZIP50 in Arabidopsis significantly increases plant zinc accumulation under control zinc supply, suggesting an altered Zn sensing in OsbZIP50. In addition, we performed a phylogenetic analysis of F-bZIP homologs from representative monocot species that supports the branching of plant F-bZIPs into Group 1 and Group 2. Our results suggest that regulation of the zinc deficiency response in rice is conserved, with OsbZIP48 being a functional homolog of AtbZIP19 and AtbZIP23. A better understanding of the mechanisms behind the Zn deficiency response in rice and other important crops will contribute to develop plant-based strategies to address the problems of Zn deficiency in soils, crops, and cereal-based human diets.<\/jats:p>","DOI":"10.1093\/jxb\/eraa115","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T20:19:38Z","timestamp":1583180378000},"page":"3664-3677","source":"Crossref","is-referenced-by-count":66,"title":["Rice F-bZIP transcription factors regulate the zinc deficiency response"],"prefix":"10.1093","volume":"71","author":[{"given":"Grmay H","family":"Lilay","sequence":"first","affiliation":[{"name":"Department of Plant and Environmental Sciences, Copenhagen Plant Science Centre, University of Copenhagen, Frederiksberg-C, Denmark"}]},{"given":"Pedro Humberto","family":"Castro","sequence":"first","affiliation":[{"name":"CIBIO-InBIO, Research Centre in Biodiversity and Genetic Resources, Campus Agr\u00e1rio de Vair\u00e3o, University of Porto, Vair\u00e3o, Portugal"}]},{"given":"Joana G","family":"Guedes","sequence":"first","affiliation":[{"name":"CIBIO-InBIO, Research Centre in Biodiversity and Genetic Resources, Campus Agr\u00e1rio de Vair\u00e3o, University of Porto, Vair\u00e3o, Portugal"}]},{"given":"Diego M","family":"Almeida","sequence":"first","affiliation":[{"name":"Genomics of Plant Stress Laboratory, Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, New University of Lisbon, Oeiras, Portugal"}]},{"given":"Ana","family":"Campilho","sequence":"first","affiliation":[{"name":"CIBIO-InBIO, Research Centre in Biodiversity and Genetic Resources, Campus Agr\u00e1rio de Vair\u00e3o, University of Porto, Vair\u00e3o, Portugal"},{"name":"Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal"}]},{"given":"Herlander","family":"Azevedo","sequence":"first","affiliation":[{"name":"CIBIO-InBIO, Research Centre in Biodiversity and Genetic Resources, Campus Agr\u00e1rio de Vair\u00e3o, University of Porto, Vair\u00e3o, Portugal"},{"name":"Department of Biology, Faculty of Sciences, University of Porto, Porto, Portugal"}]},{"given":"Mark G M","family":"Aarts","sequence":"first","affiliation":[{"name":"Laboratory of Genetics, Wageningen University& Research, Wageningen, The Netherlands"}]},{"given":"Nelson J M","family":"Saibo","sequence":"first","affiliation":[{"name":"Genomics of Plant Stress Laboratory, Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, New University of Lisbon, Oeiras, Portugal"}]},{"given":"Ana G L","family":"Assun\u00e7\u00e3o","sequence":"first","affiliation":[{"name":"Department of Plant and Environmental Sciences, Copenhagen Plant Science Centre, University of Copenhagen, Frederiksberg-C, Denmark"},{"name":"CIBIO-InBIO, Research Centre in Biodiversity and Genetic Resources, Campus Agr\u00e1rio de Vair\u00e3o, University of Porto, Vair\u00e3o, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"2020062213333903400_CIT0001","volume-title":"Zinc in soils and crop nutrition","author":"Alloway","year":"2008"},{"key":"2020062213333903400_CIT0002","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-1-4939-3356-3_14","article-title":"Screening for abiotic stress tolerance in rice: salt, cold, and drought","volume":"1398","author":"Almeida","year":"2016","journal-title":"Methods in Molecular Biology"},{"key":"2020062213333903400_CIT0003","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11103-016-0547-7","article-title":"Five novel transcription factors as potential regulators of OsNHX1 gene expression in a salt tolerant rice genotype","volume":"93","author":"Almeida","year":"2017","journal-title":"Plant Molecular Biology"},{"key":"2020062213333903400_CIT0004","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1021\/pr0603699","article-title":"Zinc 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