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Some of the most promising approaches encompass the complexation of nucleic acids, which are anionic, with liposomes of fixed or ionizable cationic charge. Thus, the main purpose of this work was to study the complexation of cationic liposomes with anti-EFG1 2\u2032OMe oligomers and evaluate the complex efficacy to control Candida albicans filamentation in vitro and in vivo using a Galleria mellonella model.<\/jats:p>\n               <jats:p>To accomplish this, cationic dioleoyl-trimethylammoniumpropane (DOTAP) was mixed with three different neutral lipids dioleoyl-phosphocholine (DOPC), dioleoyl-phosphatidylethanolamine (DOPE) and monoolein (MO) and used as delivery vectors. Fluorescence Cross Correlation Spectroscopy measurements revealed a high association between antisense oligomers (ASO) and cationic liposomes confirming the formation of lipoplexes. In vitro, all cationic liposome-ASO complexes were able to release the anti-EFG1 2\u2032OMe oligomers and consequently inhibit C. albicans filamentation up to 60% after 72\u00a0h. In vivo, from all formulations the DOTAP\/DOPC 80\/20 \u03c1chg\u00a0=\u00a03 formulation proved to be the most effective, enhancing the G. mellonella survival by 40% within 48\u00a0h and by 25% after 72\u00a0h of infection.<\/jats:p>\n               <jats:p>In this sense, our findings show that DOTAP-based lipoplexes are very good candidates for nano-carriers of anti-EFG1 2\u2032OMe oligomers.<\/jats:p>","DOI":"10.1093\/mmy\/myac030","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T11:16:43Z","timestamp":1651231003000},"source":"Crossref","is-referenced-by-count":6,"title":["Cationic lipid-based formulations for encapsulation and delivery of anti-<i>EFG1<\/i> 2\u2032\n<i>O<\/i>MethylRNA oligomer"],"prefix":"10.1093","volume":"60","author":[{"given":"Daniela","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"LIBRO \u2013 Laborat\u00f3rio de Investiga\u00e7\u00e3o em Biofilmes Ros\u00e1rio Oliveira, CEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal"},{"name":"LABBELS Associate Laboratory, 4800-122 Braga, Guimar\u00e3es, Portugal"}]},{"given":"Ricardo","family":"Gaspar","sequence":"additional","affiliation":[{"name":"INL-International Iberian Nanotechnology Laboratory, Av. Mestre Jos\u00e9 Veiga, 4715-310 Braga, Portugal"}]},{"given":"Dalila","family":"Mil-Homens","sequence":"additional","affiliation":[{"name":"iBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Lisbon University, 1049-001 Lisbon, Portugal"}]},{"given":"Mariana","family":"Henriques","sequence":"additional","affiliation":[{"name":"LIBRO \u2013 Laborat\u00f3rio de Investiga\u00e7\u00e3o em Biofilmes Ros\u00e1rio Oliveira, CEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal"},{"name":"LABBELS Associate Laboratory, 4800-122 Braga, Guimar\u00e3es, Portugal"}]},{"given":"Bruno F B","family":"Silva","sequence":"additional","affiliation":[{"name":"INL-International Iberian Nanotechnology Laboratory, Av. Mestre Jos\u00e9 Veiga, 4715-310 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-7387","authenticated-orcid":false,"given":"S\u00f3nia","family":"Silva","sequence":"additional","affiliation":[{"name":"LIBRO \u2013 Laborat\u00f3rio de Investiga\u00e7\u00e3o em Biofilmes Ros\u00e1rio Oliveira, CEB - Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal"},{"name":"LABBELS Associate Laboratory, 4800-122 Braga, Guimar\u00e3es, Portugal"},{"name":"INIAV, IP-National Institute for Agrarian and Veterinary, Rua dos Lagios, Lugar da Madalena, Vair\u00e3o, 4485-665 Vila do Conde, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"2022051902560126500_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1099\/jmm.0.045054-0","article-title":"Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options","volume":"62","author":"Sardi","year":"2013","journal-title":"J Med Microbiol"},{"key":"2022051902560126500_bib2","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1086\/599039","article-title":"Epidemiology and outcomes of Candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry","volume":"48","author":"Horn","year":"2009","journal-title":"Clin Infect Dis"},{"key":"2022051902560126500_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/TCRM.S40160","article-title":"Epidemiology and risk factors for invasive candidiasis","volume":"10","author":"Yapar","year":"2014","journal-title":"Ther Clin Risk Manag"},{"key":"2022051902560126500_bib4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3109\/1040841X.2015.1091805","article-title":"Vulvovaginal candidiasis: epidemiology, microbiology and risk factors","volume":"42","author":"Gon\u00e7alves","year":"2016","journal-title":"Crit Rev Microbiol"},{"key":"2022051902560126500_bib5","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.cmi.2019.04.024","article-title":"Morbidity and mortality of candidaemia in Europe: an epidemiologic meta-analysis","volume":"25","author":"Koehler","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"2022051902560126500_bib6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tim.2016.09.004","article-title":"Portrait of Candida species biofilm regulatory network genes","volume":"1","author":"Ara\u00fajo","year":"2017","journal-title":"Trends Microbiol"},{"key":"2022051902560126500_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/jof3010008","article-title":"Candida species biofilms\u2019 antifungal resistance","volume":"3","author":"Silva","year":"2017","journal-title":"J Fungi"},{"key":"2022051902560126500_bib8","first-page":"61","article-title":"From genes to networks: the regulatory circuitry controlling Candidaalbicans morphogenesis","volume":"422","author":"Basso","year":"2018","journal-title":"Curr Top Microbiol Immunol"},{"key":"2022051902560126500_bib9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/21505594.2020.1748930","article-title":"The regulation of hyphae growth in Candidaalbicans","volume":"11","author":"Chen","year":"2020","journal-title":"Virulence"},{"key":"2022051902560126500_bib10","first-page":"900","article-title":"[Inhibition of hepatitis B virus (HBV) replication using antisense LNA targeting to both S and C genes in HBV]","volume":"17","author":"Deng","year":"2009","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"2022051902560126500_bib11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/ijc.28704","article-title":"Antisense oligonucleotides against TNFR1 prevent toxicity of TNF\/IFN\u03b3 treatment in mouse tumor models","volume":"135","author":"Van Hauwermeiren","year":"2014","journal-title":"Int J Cancer"},{"key":"2022051902560126500_bib12","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1517\/14728222.2015.1056155","article-title":"Therapeutic targets for the treatment of hepatitis E virus infection","volume":"19","author":"Kenney","year":"2015","journal-title":"Expert Opin Ther Targets"},{"key":"2022051902560126500_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0004456","article-title":"Delayed time-to-treatment of an antisense morpholino oligomer is effective against lethal Marburg virus infection. 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