{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:00:59Z","timestamp":1776214859107,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2016\/22039-4"],"award-info":[{"award-number":["2016\/22039-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009091","name":"Fundaci\u00f3 Catalana de Trasplantament","doi-asserted-by":"publisher","award":["UID\/BIO\/04565\/2013"],"award-info":[{"award-number":["UID\/BIO\/04565\/2013"]}],"id":[{"id":"10.13039\/501100009091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009091","name":"Fundaci\u00f3 Catalana de Trasplantament","doi-asserted-by":"publisher","award":["UID\/BIO\/04565\/2019"],"award-info":[{"award-number":["UID\/BIO\/04565\/2019"]}],"id":[{"id":"10.13039\/501100009091","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa Operacional Regional de Lisboa"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The continuous emergence of Candida strains resistant to currently used antifungals demands the development of new alternatives that could reduce the burden of candidiasis. In this work silver nanoparticles synthesized using a green route are efficiently used, alone or in combination with fluconazole, amphotericin B or nystatine, to inhibit growth of C. albicans and C. glabrata oral clinical strains, including in strains showing resistance to fluconazole. A potent inhibitory effect over biofilm formation prompted by the two Candida species was also observed, including in mature biofilm cells. These results foster the use of phytotherapeutics as effective treatments in oral candidiasis.<\/jats:p>","DOI":"10.1093\/mmy\/myz094","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T15:27:28Z","timestamp":1567610848000},"page":"564-567","source":"Crossref","is-referenced-by-count":7,"title":["Study of the activity of\n                    <i>Punica granatum<\/i>\n                    -mediated silver nanoparticles against\n                    <i>Candida albicans<\/i>\n                    and\n                    <i>Candida glabrata<\/i>\n                    , alone or in combination with azoles or polyenes"],"prefix":"10.1093","volume":"58","author":[{"given":"Jos\u00e9 Ant\u00f3nio Santos","family":"Souza","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) , School of Dentistry Ara\u00e7atuba, Department of Pediatric Dentistry and Public Health, Ara\u00e7atuba, S\u00e3o Paulo,","place":["Brazil"]}]},{"given":"Marta M","family":"Alves","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, Universidade de Lisboa , Lisbon,","place":["Portugal"]}]},{"given":"Debora Barros","family":"Barbosa","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) , School of Dentistry Ara\u00e7atuba, Department of Dental Materials and Prosthodontics, S\u00e3o Paulo,","place":["Brazil"]}]},{"given":"Maria Manuel","family":"Lopes","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia da Universidade de Lisboa , Departamento de Microbiologia e Imunologia, Av. Prof. Gama Pinto, 1649-003 Lisbon"}]},{"given":"Eug\u00e9nia","family":"Pinto","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy of University of Porto , Rua de Jorge Viterbo Ferreira, 228, 4050\u2013313 Porto,","place":["Portugal"]},{"name":"Interdisciplinary Centre of Marine and Environmental Research (CIIMAR\/CIMAR), University of Porto , Terminal de Cruzeiros do Porto de Leix\u00f5es, Avenida General Norton de Matos, 4450-208 Matosinhos,","place":["Portugal"]}]},{"given":"Maria Helena","family":"Figueiral","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Porto University , Rua Manuel Pereira da Silva, 4200\u2013392 Porto,","place":["Portugal"]}]},{"given":"Alberto Carlos B","family":"Delbem","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP) , School of Dentistry Ara\u00e7atuba, Department of Pediatric Dentistry and Public Health, Ara\u00e7atuba, S\u00e3o Paulo,","place":["Brazil"]}]},{"given":"Nuno Pereira","family":"Mira","sequence":"additional","affiliation":[{"name":"iBB, Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico \u2013 Department of Bioengineering, Universidade de Lisboa , Lisbon,","place":["Portugal"]}]}],"member":"286","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"key":"2026041420081949100_bib1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3109\/1040841X.2011.585606","article-title":"Oral candidosis-clinical challenges of a biofilm disease","volume":"37","author":"Rautemaa","year":"2011","journal-title":"Crit Rev Microbiol"},{"key":"2026041420081949100_bib2","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1128\/jcm.26.12.2626-2631.1988","article-title":"In vitro susceptibilities and biotypes of Candida albicans isolates from the oral cavities of patients infected with human immunodeficiency 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