{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T18:59:05Z","timestamp":1648753145469},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Institute of Biomedical Sciences Abel Salazar of the University of Porto"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alcohol oxidases and dehydrogenases are poorly studied in the Mollusca, the second largest phylum of metazoans. In order to obtain an overview of the distribution of aromatic alcohols and ethanol-oxidizing enzymes in the gastropod phylogenetic tree, we investigated the activity of these enzymes in the digestive gland of 26 gastropod species in the clades Patellogastropoda, Neritimorpha, Vetigastropoda, Caenogastropoda and Heterobranchia. Marine, freshwater and terrestrial species, as well as herbivores and carnivores, were sampled so that gastropods varying widely in habitat and diet were included in the study. An aromatic alcohol oxidase, which was previously reported in herbivorous terrestrial gastropods, was detected in 25 of the studied species. The activity of a cinnamyl alcohol dehydrogenase was detected for the first time in gastropods and this enzyme was found to be present in all the species that were studied. Our study, thus, demonstrates that alcohol oxidases and dehydrogenases are ubiquitous enzymes among gastropods; these enzymes are found across the gastropod phylogenetic tree and across species varying widely in habitat and diet. The enzymes that catalyze the oxidation or dehydrogenation of cinnamyl alcohol must be involved in the metabolism of aromatic alcohols of very different dietary origins and conceivably have a detoxification function. Oxidase or dehydrogenase activities involving ethanol as a substrate were detected only in a few species, mostly those belonging to the Panpulmonata. This suggests that for many gastropods ethanol may not be metabolically relevant.<\/jats:p>","DOI":"10.1093\/mollus\/eyz025","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T19:11:33Z","timestamp":1560798693000},"page":"397-402","source":"Crossref","is-referenced-by-count":0,"title":["Oxidation of cinnamyl alcohol and ethanol by oxidases and dehydrogenases in the digestive gland of gastropods"],"prefix":"10.1093","volume":"85","author":[{"given":"Alexandre","family":"Lobo-da-Cunha","sequence":"first","affiliation":[{"name":"Departamento de Microscopia, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental, 4450-208 Matosinhos, Portugal"}]},{"given":"Diogo","family":"Amaral-de-Carvalho","sequence":"additional","affiliation":[{"name":"Departamento de Microscopia, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"}]},{"given":"Gon\u00e7alo","family":"Calado","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias da Vida, Universidade Lus\u00f3fona de Humanidades e Tecnologias, Av. do Campo Grande, 376, 1749-024 Lisboa, Portugal"},{"name":"MARE NOVA (Marine and Environmental Sciences Centre) - Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Departamento de Ci\u00eancias e Engenharia do Ambiente, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"given":"V\u00edtor","family":"Costa","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Molecular, ICBAS, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; and"},{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"2021041513061760100_ref1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1021\/np50082a016","article-title":"Isolation of new aromatic derivatives from marine algal species Caulerpa racemosa","volume":"55","author":"ANJANEYULU","year":"1992","journal-title":"Journal of Natural Products"},{"key":"2021041513061760100_ref2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.fct.2004.09.013","article-title":"A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients","volume":"43","author":"BICKERS","year":"2005","journal-title":"Food Chemistry and 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