{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T12:29:39Z","timestamp":1753360179880,"version":"3.37.3"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pediatric uveitis poses challenges in diagnosis and treatment due to asymptomatic or oligosymptomatic presentations and high rates of intraocular complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to characterize clinical manifestations and treatment approaches of pediatric uveitis patients in a northern Portuguese tertiary hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methodology<\/jats:title>\n                  <jats:p>A retrospective study was conducted involving 41 patients diagnosed with uveitis between 2006 and 2021. All individuals identified by the Opthalmology department were referred to Pediatric Rheumatology outpatient clinic. Demographic, clinical, treatment, and intraocular complications data were collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the patients, 78% had anterior uveitis, 17% had panuveitis, and 5% had intermediate uveitis. Uveitis associated with juvenile idiopathic arthritis (JIA) was the most common cause (43.9%), predominantly in the oligoarticular, anti-nuclear antibody-positive subgroup. Complications were identified in 80.5% of the patients. Uveitis associated with JIA was diagnosed earlier [5.0\u2009years (3.0\u201310.5) vs. 9.0\u2009years (5.5\u201314.0), P\u2009=\u2009.036], more frequently in asymptomatic patients (71% vs. 23%, P\u2009=\u2009.010), had a more insidious installation (71% vs. 17%, P\u2009=\u2009.004), and required more tumor necrosis factor (TNF) inhibitor treatment (70% vs. 39%, P\u2009=\u2009.027).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The high rates of intraocular complications and systemic pathology association highlight the need for a combined approach of ophthalmology and pediatric rheumatology in the diagnosis and treatment of pediatric uveitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/road083","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T12:35:09Z","timestamp":1691670909000},"page":"798-805","source":"Crossref","is-referenced-by-count":1,"title":["Non-infectious uveitis referred for\u00a0pediatric rheumatologic assessment and\u00a0management: A Portuguese retrospective study"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1700-2179","authenticated-orcid":false,"given":"Hugo","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto , Porto, Portugal"}]},{"given":"S\u00e9rgio","family":"Alves","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Centro Materno-Infantil do Norte, Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio , Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-090X","authenticated-orcid":false,"given":"Liane","family":"Correia-Costa","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto , Porto, Portugal"},{"name":"EPIUnit \u2013 Instituto de Sa\u00fade P\u00fablica, Universidade do Porto , Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR) , Porto, Portugal"},{"name":"Division of Pediatric Nephrology, Centro Materno-Infantil do Norte, Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio , Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6066-6918","authenticated-orcid":false,"given":"Vasco","family":"Miranda","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio , Porto, Portugal"},{"name":"Digital Health Laboratory, Centro 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