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However, there has not been a recommended long-term positive control for this version of the comet assay. We have investigated potassium bromate as a positive control for the Fpg-modified comet assay because it generates many Fpg-sensitive sites with a little concurrent generation of DNA strand breaks. Eight laboratories used the same procedure for the treatment of monocytic THP-1 cells with potassium bromate (0, 0.5, 1.5, and 4.5 mM) and subsequent cryopreservation in a freezing medium consisting of 50% foetal bovine serum, 40% RPMI-1640 medium, and 10% dimethyl sulphoxide. The samples were analysed by the Fpg-modified comet assay three times over a 3-year period. All laboratories obtained a positive concentration\u2013response relationship in cryopreserved samples (linear regression coefficients ranging from 0.79 to 0.99). However, there was a wide difference in the levels of Fpg-sensitive sites between the laboratory with the lowest (4.2% Tail DNA) and highest (74% Tail DNA) values in THP-1 cells after exposure to 4.5 mM KBrO3. In an attempt to assess sources of inter-laboratory variation in Fpg-sensitive sites, comet images from one experiment in each laboratory were forwarded to a central laboratory for visual scoring. There was high consistency between measurements of %Tail DNA values in each laboratory and the visual score of the same comets done in the central laboratory (r = 0.98, P &amp;lt; 0.001, linear regression). In conclusion, the results show that potassium bromate is a suitable positive comet assay control.<\/jats:p>","DOI":"10.1093\/mutage\/gead020","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T09:16:43Z","timestamp":1687771003000},"page":"264-272","source":"Crossref","is-referenced-by-count":12,"title":["Long-term cryopreservation of potassium bromate positive assay controls for measurement of oxidatively damaged DNA by the Fpg-modified comet assay: results from the hCOMET ring trial"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-1249","authenticated-orcid":false,"given":"Peter","family":"M\u00f8ller","sequence":"first","affiliation":[{"name":"Department of Public Health, Section of Environmental Health, University of Copenhagen , \u00d8ster Farimagsgade 5A, DK-1014 Copenhagen K , Denmark"}]},{"given":"Amaya","family":"Azqueta","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy and Nutrition, University of Navarra , C\/Irunlarrea 1, 31009 Pamplona , Spain"}]},{"given":"Adriana","family":"Rodriguez-Garraus","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy and Nutrition, University of Navarra , C\/Irunlarrea 1, 31009 Pamplona , Spain"}]},{"given":"Tamara","family":"Bakuradze","sequence":"additional","affiliation":[{"name":"Food Chemistry and Toxicology, Department of Chemistry, Rhineland-Palatinate Technical University Kaiserslautern-Landau , Erwin-Schroedinger-Str. 52, D-67663 Kaiserslautern , Germany"}]},{"given":"Elke","family":"Richling","sequence":"additional","affiliation":[{"name":"Food Chemistry and Toxicology, Department of Chemistry, Rhineland-Palatinate Technical University Kaiserslautern-Landau , Erwin-Schroedinger-Str. 52, D-67663 Kaiserslautern , Germany"}]},{"given":"Ezgi Eyluel","family":"Bankoglu","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University of Wuerzburg , Versbacher Str. 9, 97078 Wuerzburg , Germany"}]},{"given":"Helga","family":"Stopper","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Toxicology, University of Wuerzburg , Versbacher Str. 9, 97078 Wuerzburg , Germany"}]},{"given":"Victoria","family":"Claudino Bastos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University , Maastricht , The Netherlands"}]},{"given":"Sabine A S","family":"Langie","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University , Maastricht , The Netherlands"}]},{"given":"Annie","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section of Environmental Health, University of Copenhagen , \u00d8ster Farimagsgade 5A, DK-1014 Copenhagen K , Denmark"}]},{"given":"Sara","family":"Ristori","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Pharmacology and Child Health (NEUROFARBA), Section Pharmacology and Toxicology, University of Florence , Florence , Italy"}]},{"given":"Francesca","family":"Scavone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Pharmacology and Child Health (NEUROFARBA), Section Pharmacology and Toxicology, University of Florence , Florence , Italy"}]},{"given":"Lisa","family":"Giovannelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Pharmacology and Child Health (NEUROFARBA), Section Pharmacology and Toxicology, University of Florence , Florence , Italy"}]},{"given":"Maria","family":"Wojew\u00f3dzka","sequence":"additional","affiliation":[{"name":"Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology , Dorodna 16, 01-310 Warsaw , Poland"}]},{"given":"Marcin","family":"Kruszewski","sequence":"additional","affiliation":[{"name":"Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology , Dorodna 16, 01-310 Warsaw , Poland"},{"name":"Department of Molecular Biology and Translational Research, Institute of Rural Health , Jaczewskiego 2, 20-090 Lublin , Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5572-1089","authenticated-orcid":false,"given":"Vanessa","family":"Valdiglesias","sequence":"additional","affiliation":[{"name":"Universidade da Coru\u00f1a, Grupo NanoToxGen, Centro Interdisciplinar de Qu\u00edmica e Biolox\u00eda \u2013 CICA, Departamento de Biolog\u00eda , A Coru\u00f1a , Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC) , A Coru\u00f1a , Spain"}]},{"given":"Blanca","family":"Laffon","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC) , A Coru\u00f1a , Spain"},{"name":"Universidade da Coru\u00f1a, Grupo DICOMOSA, Centro Interdisciplinar de Qu\u00edmica e Biolox\u00eda \u2013 CICA, Departamento de Psicolog\u00eda , A Coru\u00f1a , Spain"}]},{"given":"Carla","family":"Costa","sequence":"additional","affiliation":[{"name":"Environmental Health Department, National Institute of Health , Porto , Portugal"},{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto , Porto , Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR) , Porto , Portugal"}]},{"given":"Solange","family":"Costa","sequence":"additional","affiliation":[{"name":"Environmental Health Department, National Institute of Health , Porto , Portugal"},{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto , Porto , Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR) , Porto , Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8693-5250","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Paulo Teixeira","sequence":"additional","affiliation":[{"name":"Environmental Health Department, National Institute of Health , Porto , Portugal"},{"name":"EPIUnit\u2014Instituto de Sa\u00fade P\u00fablica, Universidade do Porto , Porto , Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR) , Porto , Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-4380","authenticated-orcid":false,"given":"Mirko","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Food, Environmental and Nutritional Sciences (DeFENS), Universita\u0300 degli Studi di Milano , 20133 Milan , Italy"}]},{"given":"Cristian","family":"Del Bo\u2019","sequence":"additional","affiliation":[{"name":"Department of Food, Environmental and Nutritional Sciences (DeFENS), Universita\u0300 degli Studi di Milano , 20133 Milan , Italy"}]},{"given":"Patrizia","family":"Riso","sequence":"additional","affiliation":[{"name":"Department of Food, Environmental and Nutritional Sciences (DeFENS), Universita\u0300 degli Studi di Milano , 20133 Milan , Italy"}]},{"given":"Congying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University , Maastricht , The Netherlands"},{"name":"Department of Nutrition, University of Oslo , Norway"}]},{"given":"Sergey","family":"Shaposhnikov","sequence":"additional","affiliation":[{"name":"NorGenotech AS , Oslo , Norway"}]},{"given":"Andrew","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of Oslo , Norway"},{"name":"NorGenotech AS , Oslo , 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