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It promotes the biogenesis of cellular machineries but it is unclear how it discriminates closely related client proteins. Among the main PAQosome clients are C\/D snoRNPs and in particular their core protein NOP58. Using NOP58 mutants and proteomic experiments, we identify different assembly intermediates and show that C12ORF45, which we rename NOPCHAP1, acts as a bridge between NOP58 and PAQosome. NOPCHAP1 makes direct physical interactions with the CC-NOP domain of NOP58 and domain II of RUVBL1\/2 AAA+ ATPases. Interestingly, NOPCHAP1 interaction with RUVBL1\/2 is disrupted upon ATP binding. Moreover, while it robustly binds both yeast and human NOP58, it makes little interactions with NOP56 and PRPF31, two other closely related CC-NOP proteins. Expression of NOP58, but not NOP56 or PRPF31, is decreased in NOPCHAP1 KO cells. We propose that NOPCHAP1 is a client-loading PAQosome cofactor that selects NOP58 to promote box C\/D snoRNP assembly.<\/jats:p>","DOI":"10.1093\/nar\/gkaa1226","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T06:14:05Z","timestamp":1607753645000},"page":"1094-1113","source":"Crossref","is-referenced-by-count":22,"title":["NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1\/2 during box C\/D snoRNP biogenesis"],"prefix":"10.1093","volume":"49","author":[{"given":"Yoann","family":"Abel","sequence":"first","affiliation":[{"name":"IGMM, CNRS, Univ Montpellier, Montpellier, France"},{"name":"Equipe labellis\u00e9e Ligue Nationale Contre le Cancer, Montpellier, France"},{"name":"IGH, CNRS, Univ Montpellier,\u00a0Montpellier, France"}]},{"given":"Ana C F","family":"Paiva","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras, 2781-901, Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, Oeiras, 2780-157, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-3951","authenticated-orcid":false,"given":"Jonathan","family":"Bizarro","sequence":"additional","affiliation":[{"name":"IGMM, CNRS, Univ Montpellier, Montpellier, France"},{"name":"Equipe labellis\u00e9e Ligue Nationale Contre le Cancer, Montpellier, France"}]},{"given":"Marie-Eve","family":"Chagot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"}]},{"given":"Paulo\u00a0E","family":"Santo","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras, 2781-901, Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, Oeiras, 2780-157, Portugal"}]},{"given":"Marie-C\u00e9cile","family":"Robert","sequence":"additional","affiliation":[{"name":"IGMM, CNRS, Univ Montpellier, Montpellier, France"},{"name":"Equipe labellis\u00e9e Ligue Nationale Contre le Cancer, Montpellier, France"},{"name":"IGH, CNRS, Univ Montpellier,\u00a0Montpellier, France"}]},{"given":"Marc","family":"Quinternet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, CNRS, INSERM, IBSLor, Biophysics and Structural Biology Core Facility, F-54000,\u00a0Nancy, France"}]},{"given":"Franck","family":"Vandermoere","sequence":"additional","affiliation":[{"name":"IGF, CNRS, INSERM, Univ Montpellier, Montpellier, France"}]},{"given":"Pedro M F","family":"Sousa","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras, 2781-901, Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, Oeiras, 2780-157, Portugal"}]},{"given":"Philippe","family":"Fort","sequence":"additional","affiliation":[{"name":"CRBM, CNRS, Univ Montpellier,\u00a0Montpellier, France"}]},{"given":"Bruno","family":"Charpentier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"}]},{"given":"Xavier","family":"Manival","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, CNRS, IMoPA, F-54000 Nancy, France"}]},{"given":"Tiago\u00a0M","family":"Bandeiras","sequence":"additional","affiliation":[{"name":"iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, Oeiras, 2781-901, Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, Oeiras, 2780-157, Portugal"}]},{"given":"Edouard","family":"Bertrand","sequence":"additional","affiliation":[{"name":"IGMM, CNRS, Univ Montpellier, Montpellier, France"},{"name":"Equipe labellis\u00e9e Ligue Nationale Contre le Cancer, Montpellier, France"},{"name":"IGH, CNRS, Univ Montpellier,\u00a0Montpellier, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2459-9700","authenticated-orcid":false,"given":"C\u00e9line","family":"Verheggen","sequence":"additional","affiliation":[{"name":"IGMM, CNRS, Univ Montpellier, Montpellier, France"},{"name":"Equipe labellis\u00e9e Ligue Nationale Contre le Cancer, Montpellier, France"},{"name":"IGH, CNRS, Univ Montpellier,\u00a0Montpellier, France"}]}],"member":"286","published-online":{"date-parts":[[2020,12,24]]},"reference":[{"key":"2021012319510780800_B1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1101\/sqb.2006.71.001","article-title":"The SMN complex: an assembly machine for RNPs","volume":"71","author":"Battle","year":"2006","journal-title":"Cold Spring Harb. 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