{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:32:02Z","timestamp":1775694722424,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"D1","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of University and Research","award":["2017483NH8"],"award-info":[{"award-number":["2017483NH8"]}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["778247"],"award-info":[{"award-number":["778247"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020","doi-asserted-by":"publisher","award":["952334"],"award-info":[{"award-number":["952334"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marie Sk\u0142odowska-Curie","award":["842490"],"award-info":[{"award-number":["842490"]}]},{"DOI":"10.13039\/501100013948","name":"Tempus Public Foundation","doi-asserted-by":"publisher","award":["158534"],"award-info":[{"award-number":["158534"]}],"id":[{"id":"10.13039\/501100013948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"NRDI Office","doi-asserted-by":"publisher","award":["FK128133"],"award-info":[{"award-number":["FK128133"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Agency for the Promotion of Science and Technology","award":["PICT-2017-1924"],"award-info":[{"award-number":["PICT-2017-1924"]}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["FPU17\/01157"],"award-info":[{"award-number":["FPU17\/01157"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marie Sklodowska-Curie","award":["101028908"],"award-info":[{"award-number":["101028908"]}]},{"name":"Swedish Research Council for Natural Science","award":["VR-2016-06301"],"award-info":[{"award-number":["VR-2016-06301"]}]},{"DOI":"10.13039\/100017156","name":"Swedish E-science Research Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017156","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["U41 HG02273"],"award-info":[{"award-number":["U41 HG02273"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012681","name":"CNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012681","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Infectiop\u00f4le Sud post-doctoral fellowship"},{"name":"ELIXIR CZ Research Infrastructure","award":["LM2018131"],"award-info":[{"award-number":["LM2018131"]}]},{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009559","name":"Universidad Nacional de Quilmes","doi-asserted-by":"publisher","award":["PUNQ-2019-1309\/19"],"award-info":[{"award-number":["PUNQ-2019-1309\/19"]}],"id":[{"id":"10.13039\/501100009559","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Agency for the Promotion of Science and Technology","award":["PICT-2018-3457"],"award-info":[{"award-number":["PICT-2018-3457"]}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["K124670"],"award-info":[{"award-number":["K124670"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["K131702"],"award-info":[{"award-number":["K131702"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["K129164"],"award-info":[{"award-number":["K129164"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"publisher","award":["K139284"],"award-info":[{"award-number":["K139284"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004418","name":"VUB","doi-asserted-by":"publisher","award":["SRP51, 2019\u201324"],"award-info":[{"award-number":["SRP51, 2019\u201324"]}],"id":[{"id":"10.13039\/501100004418","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Elixir-GR","award":["MIS 5002780"],"award-info":[{"award-number":["MIS 5002780"]}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C68484\/A28159"],"award-info":[{"award-number":["C68484\/A28159"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012996","name":"University of Cyprus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Database of Intrinsically Disordered Proteins (DisProt, URL: https:\/\/disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.<\/jats:p>","DOI":"10.1093\/nar\/gkab1082","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T23:13:35Z","timestamp":1634771615000},"page":"D480-D487","source":"Crossref","is-referenced-by-count":163,"title":["DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0341-4888","authenticated-orcid":false,"given":"Federica","family":"Quaglia","sequence":"first","affiliation":[{"name":"Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR-IBIOM), Bari, Italy"},{"name":"Department of Biomedical Sciences, University of Padova, Padova, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0919-4449","authenticated-orcid":false,"given":"B\u00e1lint","family":"M\u00e9sz\u00e1ros","sequence":"additional","affiliation":[{"name":"Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg\u00a069117, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5152-5953","authenticated-orcid":false,"given":"Edoardo","family":"Salladini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, Padova, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9224-9820","authenticated-orcid":false,"given":"Andr\u00e1s","family":"Hatos","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, Padova, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0849-9312","authenticated-orcid":false,"given":"Rita","family":"Pancsa","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Budapest\u00a01117, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-9906","authenticated-orcid":false,"given":"Luc\u00eda B","family":"Chemes","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas (IIBiO-CONICET), Universidad Nacional de San Mart\u00edn, Av. 25 de Mayo y Francia, CP1650 Buenos Aires, Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-9825","authenticated-orcid":false,"given":"M\u00e1ty\u00e1s","family":"Pajkos","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, E\u00f6tv\u00f6s Lor\u00e1nd University, P\u00e1zm\u00e1ny P\u00e9ter stny 1\/c, Budapest H-1117, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7496-6711","authenticated-orcid":false,"given":"Tamas","family":"Lazar","sequence":"additional","affiliation":[{"name":"VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnology, Brussels, Belgium"},{"name":"Structural Biology Brussels (SBB),\u00a0Bioengineering Sciences Department, Vrije Universiteit Brussel (VUB), Brussels, Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2902-823X","authenticated-orcid":false,"given":"Samuel","family":"Pe\u00f1a-D\u00edaz","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i Biomedicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9045-7765","authenticated-orcid":false,"given":"Jaime","family":"Santos","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i Biomedicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6260-7287","authenticated-orcid":false,"given":"Veronika","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Budapest\u00a01117, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-8578","authenticated-orcid":false,"given":"Nazanin","family":"Farahi","sequence":"additional","affiliation":[{"name":"VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnology, Brussels, Belgium"},{"name":"Structural Biology Brussels (SBB),\u00a0Bioengineering Sciences Department, Vrije Universiteit Brussel (VUB), Brussels, Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3965-8438","authenticated-orcid":false,"given":"Erzs\u00e9bet","family":"Fich\u00f3","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Budapest\u00a01117, Hungary"},{"name":"Cytocast Kft., Vecs\u00e9s, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4937-6952","authenticated-orcid":false,"given":"Maria\u00a0Cristina","family":"Aspromonte","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health, University of Padova, Padova, Italy"},{"name":"Pediatric Research Institute, Citt\u00e0 della Speranza, Padova, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7161-9028","authenticated-orcid":false,"given":"Claudio","family":"Bassot","sequence":"additional","affiliation":[{"name":"Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University,\u00a0171 21\u00a0Solna, Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1986-5007","authenticated-orcid":false,"given":"Anastasia","family":"Chasapi","sequence":"additional","affiliation":[{"name":"Biological Computation & Process Laboratory, Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, Thermi, Thessalonica 57001, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-4850","authenticated-orcid":false,"given":"Norman\u00a0E","family":"Davey","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Rd, Chelsea, London, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6097-6203","authenticated-orcid":false,"given":"Radoslav","family":"Davidovi\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Bioinformatics and Computational Chemistry, Vin\u010da Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000Belgrade, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-3872","authenticated-orcid":false,"given":"Laszlo","family":"Dobson","sequence":"additional","affiliation":[{"name":"Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg\u00a069117, Germany"},{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Budapest\u00a01117, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7115-9751","authenticated-orcid":false,"given":"Arne","family":"Elofsson","sequence":"additional","affiliation":[{"name":"Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University,\u00a0171 21\u00a0Solna, Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6218-5192","authenticated-orcid":false,"given":"G\u00e1bor","family":"Erd\u0151s","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, E\u00f6tv\u00f6s Lor\u00e1nd University, P\u00e1zm\u00e1ny P\u00e9ter stny 1\/c, Budapest H-1117, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1813-6857","authenticated-orcid":false,"given":"Pascale","family":"Gaudet","sequence":"additional","affiliation":[{"name":"Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7628-5565","authenticated-orcid":false,"given":"Michelle","family":"Giglio","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine 670 W. Baltimore St., Baltimore, MD\u00a021201, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6336-1290","authenticated-orcid":false,"given":"Juliana","family":"Glavina","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas (IIBiO-CONICET), Universidad Nacional de San Mart\u00edn, Av. 25 de Mayo y Francia, CP1650 Buenos Aires, Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0056-1177","authenticated-orcid":false,"given":"Javier","family":"Iserte","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Fundaci\u00f3n Instituto Leloir, Buenos Aires, C1405BWE, Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-0869","authenticated-orcid":false,"given":"Valent\u00edn","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i Biomedicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-0433","authenticated-orcid":false,"given":"Zs\u00f3fia","family":"K\u00e1lm\u00e1n","sequence":"additional","affiliation":[{"name":"Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Pr\u00e1ter u. 50\/A, 1083 Budapest, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0894-8627","authenticated-orcid":false,"given":"Matteo","family":"Lambrughi","sequence":"additional","affiliation":[{"name":"Cancer Structural Biology, Danish Cancer Society Research\u00a0Center, Strandboulevarden 49, 2100 Copenhagen, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8486-8461","authenticated-orcid":false,"given":"Emanuela","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health, University of Padova, Padova, Italy"},{"name":"Pediatric Research Institute, Citt\u00e0 della Speranza, Padova, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6829-6771","authenticated-orcid":false,"given":"Sonia","family":"Longhi","sequence":"additional","affiliation":[{"name":"Lab. Architecture et Fonction des Macromol\u00e9cules Biologiques (AFMB), UMR 7257, Aix Marseille University and Centre National de la Recherche Scientifique (CNRS), 163 Avenue de Luminy, Case 932, 13288, Marseille, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7698-1170","authenticated-orcid":false,"given":"Sandra","family":"Macedo-Ribeiro","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4200-135 Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-5394","authenticated-orcid":false,"given":"Emiliano","family":"Maiani","sequence":"additional","affiliation":[{"name":"Cancer Structural Biology, Danish Cancer Society Research\u00a0Center, Strandboulevarden 49, 2100 Copenhagen, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2886-3647","authenticated-orcid":false,"given":"Julia","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6564-1920","authenticated-orcid":false,"given":"Cristina","family":"Marino-Buslje","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit, Fundaci\u00f3n Instituto Leloir, Buenos Aires, C1405BWE, Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4578-4879","authenticated-orcid":false,"given":"Attila","family":"M\u00e9sz\u00e1ros","sequence":"additional","affiliation":[{"name":"VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnology, Brussels, Belgium"},{"name":"Structural Biology Brussels (SBB),\u00a0Bioengineering Sciences Department, Vrije Universiteit Brussel (VUB), Brussels, Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-8218","authenticated-orcid":false,"given":"Alexander\u00a0Miguel","family":"Monzon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, Padova, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-5785","authenticated-orcid":false,"given":"Giovanni","family":"Minervini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, Padova, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-281X","authenticated-orcid":false,"given":"Suvarna","family":"Nadendla","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine 670 W. Baltimore St., Baltimore, MD\u00a021201, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4203-5263","authenticated-orcid":false,"given":"Juliet F","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Lab. Architecture et Fonction des Macromol\u00e9cules Biologiques (AFMB), UMR 7257, Aix Marseille University and Centre National de la Recherche Scientifique (CNRS), 163 Avenue de Luminy, Case 932, 13288, Marseille, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8788-3202","authenticated-orcid":false,"given":"Marian","family":"Novotn\u00fd","sequence":"additional","affiliation":[{"name":"Dep. of Cell Biology, Faculty of Science, Vinicna 7, 128 43, Prague, Czech Republic"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0086-8657","authenticated-orcid":false,"given":"Christos\u00a0A","family":"Ouzounis","sequence":"additional","affiliation":[{"name":"Biological Computation & Process Laboratory, Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, Thermi, Thessalonica 57001, Greece"},{"name":"Biological Computation & Computational Biology Group, Artificial Intelligence & Information Analysis Lab, Department of Computer Science, Aristotle University of Thessalonica, Thessalonica\u00a054124, Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7925-6436","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Palopoli","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-5894","authenticated-orcid":false,"given":"Elena","family":"Papaleo","sequence":"additional","affiliation":[{"name":"Cancer Structural Biology, Danish Cancer Society Research\u00a0Center, Strandboulevarden 49, 2100 Copenhagen, Denmark"},{"name":"Cancer Systems Biology, Section for Bioinformatics, Department of Health and Technology, Technical University of Denmark, Lyngby, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0969-5438","authenticated-orcid":false,"given":"Pedro\u00a0Jos\u00e9\u00a0Barbosa","family":"Pereira","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4200-135 Porto, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-9939","authenticated-orcid":false,"given":"Gabriele","family":"Pozzati","sequence":"additional","affiliation":[{"name":"Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University,\u00a0171 21\u00a0Solna, Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3352-4831","authenticated-orcid":false,"given":"Vasilis\u00a0J","family":"Promponas","sequence":"additional","affiliation":[{"name":"Bioinformatics Research Laboratory, Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-5866","authenticated-orcid":false,"given":"Jordi","family":"Pujols","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i Biomedicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-9173","authenticated-orcid":false,"given":"Alma\u00a0Carolina Sanchez","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Faculty of Science, Charles University, BIOCEV, Prague\u00a0, Czech Republic"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-1282","authenticated-orcid":false,"given":"Martin","family":"Salas","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-6573","authenticated-orcid":false,"given":"Luciana Rodriguez","family":"Sawicki","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3006-2910","authenticated-orcid":false,"given":"Eva","family":"Schad","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Budapest\u00a01117, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7748-2501","authenticated-orcid":false,"given":"Aditi","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University,\u00a0171 21\u00a0Solna, Sweden"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3130-9284","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Szaniszl\u00f3","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, E\u00f6tv\u00f6s Lor\u00e1nd University, P\u00e1zm\u00e1ny P\u00e9ter stny 1\/c, Budapest H-1117, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5280-1107","authenticated-orcid":false,"given":"Konstantinos\u00a0D","family":"Tsirigos","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6562-5800","authenticated-orcid":false,"given":"Nevena","family":"Veljkovic","sequence":"additional","affiliation":[{"name":"Laboratory for Bioinformatics and Computational Chemistry, Vin\u010da Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000Belgrade, Serbia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7444-1624","authenticated-orcid":false,"given":"Gustavo","family":"Parisi","sequence":"additional","affiliation":[{"name":"Departamento de Ciencia y Tecnolog\u00eda, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9652-6351","authenticated-orcid":false,"given":"Salvador","family":"Ventura","sequence":"additional","affiliation":[{"name":"Institut de Biotecnologia i Biomedicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"ICREA, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-5937","authenticated-orcid":false,"given":"Zsuzsanna","family":"Doszt\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, E\u00f6tv\u00f6s Lor\u00e1nd University, P\u00e1zm\u00e1ny P\u00e9ter stny 1\/c, Budapest H-1117, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-9939","authenticated-orcid":false,"given":"Peter","family":"Tompa","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Budapest\u00a01117, Hungary"},{"name":"VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnology, Brussels, Belgium"},{"name":"Structural Biology Brussels (SBB),\u00a0Bioengineering Sciences Department, Vrije Universiteit Brussel (VUB), Brussels, Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4525-7793","authenticated-orcid":false,"given":"Silvio C E","family":"Tosatto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, Padova, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8210-2390","authenticated-orcid":false,"given":"Damiano","family":"Piovesan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, Padova, Italy"}]}],"member":"286","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"2022010507384220500_B1","first-page":"437","article-title":"Thousands of proteins likely to have long disordered regions","volume":"1998","author":"Romero","year":"1998","journal-title":"Pac. Symp. Biocomput. Pac. Symp. Biocomput."},{"key":"2022010507384220500_B2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrm3920","article-title":"Intrinsically disordered proteins in cellular signalling and regulation","volume":"16","author":"Wright","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2022010507384220500_B3","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1021\/cr400525m","article-title":"Classification of intrinsically disordered regions and proteins","volume":"114","author":"van\u00a0der\u00a0Lee","year":"2014","journal-title":"Chem. Rev."},{"key":"2022010507384220500_B4","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41592-021-01117-3","article-title":"Critical assessment of protein intrinsic disorder prediction","volume":"18","author":"Necci","year":"2021","journal-title":"Nat. Methods"},{"key":"2022010507384220500_B5","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1038\/s41467-021-24773-7","article-title":"flDPnn: accurate intrinsic disorder prediction with putative propensities of disorder functions","volume":"12","author":"Hu","year":"2021","journal-title":"Nat. Commun."},{"key":"2022010507384220500_B6","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.gpb.2019.01.004","article-title":"SPOT-Disorder2: improved protein intrinsic disorder prediction by ensembled deep learning","volume":"17","author":"Hanson","year":"2019","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"2022010507384220500_B7","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1002\/prot.25966","article-title":"cnnAlpha: protein disordered regions prediction by reduced amino acid alphabets and convolutional neural networks","volume":"88","author":"Oberti","year":"2020","journal-title":"Proteins"},{"key":"2022010507384220500_B8","doi-asserted-by":"crossref","first-page":"W329","DOI":"10.1093\/nar\/gky384","article-title":"IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding","volume":"46","author":"M\u00e9sz\u00e1ros","year":"2018","journal-title":"Nucleic. Acids. Res."},{"key":"2022010507384220500_B9","first-page":"D296","article-title":"ELM\u2014the eukaryotic linear motif resource in 2020","volume":"48","author":"Kumar","year":"2020","journal-title":"Nucleic. Acids. Res."},{"key":"2022010507384220500_B10","doi-asserted-by":"crossref","first-page":"D228","DOI":"10.1093\/nar\/gkw1019","article-title":"FuzDB: database of fuzzy complexes, a tool to develop stochastic structure-function relationships for protein complexes and higher-order assemblies","volume":"45","author":"Miskei","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2022010507384220500_B11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nature25762","article-title":"Extreme disorder in an ultrahigh-affinity protein complex","volume":"555","author":"Borgia","year":"2018","journal-title":"Nature"},{"key":"2022010507384220500_B12","doi-asserted-by":"crossref","first-page":"D404","DOI":"10.1093\/nar\/gkaa1021","article-title":"PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins","volume":"49","author":"Lazar","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2022010507384220500_B13","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1002\/cpbi.107","article-title":"Exploring manually curated annotations of intrinsically disordered proteins with disprot","volume":"72","author":"Quaglia","year":"2020","journal-title":"Curr. Protoc. Bioinforma."},{"key":"2022010507384220500_B14","doi-asserted-by":"crossref","first-page":"D361","DOI":"10.1093\/nar\/gkaa1058","article-title":"MobiDB: intrinsically disordered proteins in 2021","volume":"49","author":"Piovesan","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2022010507384220500_B15","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","author":"UniProt Consortium","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022010507384220500_B16","doi-asserted-by":"crossref","first-page":"D344","DOI":"10.1093\/nar\/gkz853","article-title":"PDBe-KB: a community-driven resource for structural and functional annotations","volume":"48","author":"PDBe-KB consortium","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2022010507384220500_B17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41586-020-2829-0","article-title":"Single-particle cryo-EM at atomic resolution","volume":"587","author":"Nakane","year":"2020","journal-title":"Nature"},{"key":"2022010507384220500_B18","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"2022010507384220500_B19","doi-asserted-by":"crossref","DOI":"10.1002\/prot.26171","article-title":"High-accuracy protein structure prediction in CASP14","author":"Pereira","year":"2021","journal-title":"Proteins Struct. Funct. Bioinforma."},{"key":"2022010507384220500_B20","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-021-03828-1","article-title":"Highly accurate protein structure prediction for the human proteome","volume":"596","author":"Tunyasuvunakool","year":"2021","journal-title":"Nature"},{"key":"2022010507384220500_B21","doi-asserted-by":"crossref","first-page":"e34687","DOI":"10.1371\/journal.pone.0034687","article-title":"Structural disorder in eukaryotes","volume":"7","author":"Pancsa","year":"2012","journal-title":"PLoS One"},{"key":"2022010507384220500_B22","doi-asserted-by":"crossref","first-page":"9730","DOI":"10.1021\/jacs.6b06543","article-title":"Finding our way in the dark proteome","volume":"138","author":"Bhowmick","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"2022010507384220500_B23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.drudis.2018.09.017","article-title":"Targeting intrinsically disordered proteins at the edge of chaos","volume":"24","author":"Ruan","year":"2019","journal-title":"Drug Discov. Today"},{"key":"2022010507384220500_B24","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00018-019-03347-3","article-title":"Targeting intrinsically disordered proteins involved in cancer","volume":"77","author":"Santofimia-Casta\u00f1o","year":"2020","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"2022010507384220500_B25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.chembiol.2020.09.001","article-title":"Discovery of a functional covalent ligand targeting an intrinsically disordered cysteine within MYC","volume":"28","author":"Boike","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"2022010507384220500_B26","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.3390\/cancers13143488","article-title":"Development of an androgen receptor inhibitor targeting the N-Terminal domain of androgen receptor for treatment of castration resistant prostate cancer","volume":"13","author":"Ban","year":"2021","journal-title":"Cancers"},{"key":"2022010507384220500_B27","doi-asserted-by":"crossref","first-page":"16947","DOI":"10.1038\/s41598-019-52598-4","article-title":"Novel small molecules targeting the intrinsically disordered structural ensemble of \u03b1-synuclein protect against diverse \u03b1-synuclein mediated dysfunctions","volume":"9","author":"T\u00f3th","year":"2019","journal-title":"Sci. Rep."},{"key":"2022010507384220500_B28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/science.abb8032","article-title":"Beyond aggregation: pathological phase transitions in neurodegenerative disease","volume":"370","author":"Mathieu","year":"2020","journal-title":"Science"},{"key":"2022010507384220500_B29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.tibs.2021.01.002","article-title":"Biomolecular condensates and their links to cancer progression","volume":"46","author":"Cai","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"2022010507384220500_B30","first-page":"D269","article-title":"DisProt: intrinsic protein disorder annotation in 2020","volume":"48","author":"Hatos","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2022010507384220500_B31","first-page":"baab019","article-title":"APICURON: a database to credit and acknowledge the work of biocurators","volume":"2021","author":"Hatos","year":"2021","journal-title":"Database J. Biol. Databases Curation"},{"key":"2022010507384220500_B32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.abb.2006.07.017","article-title":"Studies on titin PEVK peptides and their interaction","volume":"454","author":"Duan","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"2022010507384220500_B33","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1093\/bioinformatics\/btaa1045","article-title":"MobiDB-lite 3.0: fast consensus annotation of intrinsic disorder flavors in proteins","volume":"36","author":"Necci","year":"2020","journal-title":"Bioinformatics"},{"key":"2022010507384220500_B34","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1093-3263(00)00138-8","article-title":"Intrinsically disordered protein","volume":"19","author":"Dunker","year":"2001","journal-title":"J. Mol. Graph. Model."},{"key":"2022010507384220500_B35","first-page":"bay127","article-title":"Where differences resemble: sequence-feature analysis in curated databases of intrinsically disordered proteins","volume":"2018","author":"Necci","year":"2018","journal-title":"Database J. Biol. Databases Curation"},{"key":"2022010507384220500_B36","doi-asserted-by":"crossref","first-page":"D1186","DOI":"10.1093\/nar\/gky1036","article-title":"ECO, the Evidence & Conclusion Ontology: community standard for evidence information","volume":"47","author":"Giglio","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022010507384220500_B37","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gkaa1113","article-title":"The Gene Ontology resource: enriching a GOld mine","volume":"49","author":"Gene Ontology Consortium","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2022010507384220500_B38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"2022010507384220500_B39","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1093\/bioinformatics\/btp536","article-title":"QuickGO: a web-based tool for Gene Ontology searching","volume":"25","author":"Binns","year":"2009","journal-title":"Bioinforma. Oxf. Engl."},{"key":"2022010507384220500_B40","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.12688\/f1000research.20136.1","article-title":"An intrinsically disordered proteins community for ELIXIR","volume":"8","author":"Davey","year":"2019","journal-title":"F1000Research"},{"key":"2022010507384220500_B41","article-title":"Exploiting bioschemas markup to populate IDPcentral","author":"Gray","year":"2021","journal-title":"BioHackrXiv"}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/D1\/D480\/42058329\/gkab1082.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nar\/article-pdf\/50\/D1\/D480\/42058329\/gkab1082.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T03:14:01Z","timestamp":1641352441000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/50\/D1\/D480\/6439667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,25]]},"references-count":41,"journal-issue":{"issue":"D1","published-online":{"date-parts":[[2021,11,25]]},"published-print":{"date-parts":[[2022,1,7]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkab1082","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.741243433.793593357","asserted-by":"object"}]},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,7]]},"published":{"date-parts":[[2021,11,25]]}}}