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Yet, a lifetime of interactions conceivably have an imprint on our physiology and immune phenotype. In this work, we revealed the genetic make-up and unique composition of the known eukaryotic human DNA virome in nine organs (colon, liver, lung, heart, brain, kidney, skin, blood, hair) of 31 Finnish individuals. By integration of quantitative (qPCR) and qualitative (hybrid-capture sequencing) analysis, we identified the DNAs of 17 species, primarily herpes-, parvo-, papilloma- and anello-viruses (&amp;gt;80% prevalence), typically persisting in low copies (mean 540 copies\/ million cells). We assembled in total 70 viral genomes (&amp;gt;90% breadth coverage), distinct in each of the individuals, and identified high sequence homology across the organs. Moreover, we detected variations in virome composition in two individuals with underlying malignant\u00a0conditions. Our findings reveal unprecedented prevalences of viral DNAs in human organs and provide a fundamental ground for the investigation of disease correlates. Our results from post-mortem tissues call for investigation of the crosstalk between human DNA viruses, the host, and other microbes, as it predictably has a significant impact on our health.<\/jats:p>","DOI":"10.1093\/nar\/gkad199","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T09:31:04Z","timestamp":1678354264000},"page":"3223-3239","source":"Crossref","is-referenced-by-count":48,"title":["Unmasking the tissue-resident eukaryotic DNA virome in humans"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9504-5807","authenticated-orcid":false,"given":"Lari","family":"Py\u00f6ri\u00e4","sequence":"first","affiliation":[{"name":"Department of Virology, University of Helsinki and Helsinki University Hospital , Helsinki \u00a000290, Finland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1176-552X","authenticated-orcid":false,"given":"Diogo","family":"Pratas","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Helsinki and Helsinki University Hospital , Helsinki \u00a000290, Finland"},{"name":"Department of Electronics, Telecommunications and Informatics, University of Aveiro , Aveiro \u00a03810-193, Portugal"},{"name":"Institute of Electronics and Informatics Engineering of Aveiro, University of Aveiro , Aveiro \u00a03810-193, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1205-2399","authenticated-orcid":false,"given":"Mari","family":"Toppinen","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, University of Helsinki , Helsinki \u00a000290, Finland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-7960","authenticated-orcid":false,"given":"Klaus","family":"Hedman","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Helsinki and Helsinki University Hospital , Helsinki \u00a000290, Finland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-5248","authenticated-orcid":false,"given":"Antti","family":"Sajantila","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, University of Helsinki , Helsinki \u00a000290, Finland"},{"name":"Forensic Medicine Unit, Finnish Institute for Health and Welfare , Helsinki \u00a000271, Finland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9031-4251","authenticated-orcid":false,"given":"Maria\u00a0F","family":"Perdomo","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Helsinki and Helsinki University Hospital , Helsinki \u00a000290, Finland"}]}],"member":"286","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"2023042403140849900_B1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"2023042403140849900_B2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project","volume":"449","author":"Turnbaugh","year":"2007","journal-title":"Nature"},{"key":"2023042403140849900_B3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1101\/gr.126573.111","article-title":"Genomic analysis identifies association of fusobacterium with colorectal carcinoma","volume":"22","author":"Kostic","year":"2012","journal-title":"Genome Res."},{"key":"2023042403140849900_B4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1126\/science.1235872","article-title":"Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta","volume":"341","author":"Haiser","year":"2013","journal-title":"Science"},{"key":"2023042403140849900_B5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.chom.2015.09.008","article-title":"Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn's disease","volume":"18","author":"Lewis","year":"2015","journal-title":"Cell Host Microbe"},{"key":"2023042403140849900_B6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature18850","article-title":"Microbiome-wide association studies link dynamic microbial consortia to disease","volume":"535","author":"Gilbert","year":"2016","journal-title":"Nature"},{"key":"2023042403140849900_B7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mib.2018.08.003","article-title":"Microbial exposure and human health","volume":"44","author":"Sharma","year":"2018","journal-title":"Curr. 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